2003, Número 3
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Cir Cir 2003; 71 (3)
Inmunidad innata, receptores Toll y sepsis
Carrillo-Esper R
Idioma: Español
Referencias bibliográficas: 89
Paginas: 252-258
Archivo PDF: 109.35 Kb.
RESUMEN
La respuesta inmune innata es la primera línea de defensa contra la
infección. Los receptores semejantes a Toll (TLRs: Toll-like
receptors) reconocen al lipopolisacárido bacteriano y otros patrones
moleculares asociados a patógenos (PAPMs: Pathogen Associated
Molecular Patterns). Los eventos moleculares intracelulares
iniciados por la interacción entre TLRs y su PAPMs específicos
desencadenan respuesta inflamatoria sistémica.
La sepsis y el choque séptico son el resultado de una respuesta
inflamatoria exagerada secundaria a disregulación de la inmunidad
innata.
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