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Federación Mexicana de Ginecología y Obstetricia, A.C.

2015, Número 08

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Ginecol Obstet Mex 2015; 83 (08)


Implicaciones clínicas de la investigación básica de la preeclampsia: tolerancia inmunológica

Valencia-Ortega J, Zárate A, Saucedo R, Hernández-Valencia M, Cruz-Durán JG, Puello-Tamara E, Arechavaleta-Velasco F

Idioma: Español
Referencias bibliográficas: 108
Paginas: 505-514
Archivo PDF: 442.97 Kb.


RESUMEN

La preeclampsia es una de las principales causas de mortalidad materna y morbilidad perinatal en todo el mundo; sin embargo, su fisiopatogenia aún no está completamente clara. En la actualidad se sugiere que resulta de una ruptura de la tolerancia inmunitaria materna a los antígenos paternos en la placenta. Esto provoca una respuesta contra el trofoblasto, genera una defectuosa placentación y un ambiente hipóxico-isquémico que desencadena la respuesta inflamatoria característica del trastorno. Esta revisión detalla los mecanismos implicados en la tolerancia inmunitaria materna, su alteración en la preeclampsia y la respuesta inflamatoria.


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