medigraphic.com
ISSN 2448-8909 (Impreso)

2015, Número 3

<< Anterior Siguiente >>

Med Crit 2015; 29 (3)


Ferritina y síndrome hiperferritinémico. Su impacto en el enfermo grave; conceptos actuales

Carrillo ER, Peña PC, Zepeda MAD, Meza MJM, Neri MR, Meza ACM, Carrillo CDM, Carrillo CCA

Idioma: Español
Referencias bibliográficas: 50
Paginas: 157-166
Archivo PDF: 433.06 Kb.


RESUMEN

La ferritina es una molécula fijadora de hierro que lo almacena para que esté disponible para varias funciones celulares, pero que también es importante en otras funciones de las que destacan la inflamación, y las enfermedades neurodegenerativas y malignas. Niveles elevados de ferritina se presentan en varias enfermedades asociadas a gran inflamación, de las que destacan la enfermedad de Still del adulto, el síndrome de activación de macrófagos, la sepsis y el choque séptico y el síndrome de anticuerpos antifosfolípido catastrófico. La hiperferritinemia se asocia con incremento de mortalidad y disfunción orgánica múltiple en pacientes críticamente enfermos, por lo que los síndromes hiperferritinémicos deben de ser conocidos por el intensivista. El objetivo de este trabajo es presentar conceptos actuales relacionados a la ferritina y al síndrome hiperferritinémico.


REFERENCIAS (EN ESTE ARTÍCULO)

  1. Rosário C, Zandman-Goddard G, Meyron-Holtz EG, D’Cruz DP, Shoenfeld Y. The Hyperferritinemic Syndrome: macrophage activation syndrome, Still’s disease, septic shock and catastrophic antiphospholipidsidrome. BMC Medicine. 2013;11:185.

  2. Elizabeth CT. Ferritin: at the crossroads of iron and oxygen metabolism. J Nutr. 2003;133:1549-1553.

  3. Gozzelino R, Soares MP. Coupling Heme and Iron Metabolism via Ferritin H Chain. Antioxid Redox Signal. 2014;10:1754-1769.

  4. Knovich MA, Storey JA, Coffman LG, Torti SV, Torti FM. Ferritin for the clinician. Blood Rev. 2009;23:95-104.

  5. Wang W, Knovich MA, Coffman LG, Torti FM, Torti SV. Serum ferritin: past, present and future. Biochim Biophys Acta. 2010;1800:760-769.

  6. Recalcati S, Invernizzi P, Arosio P, Cairo G. New functions for an iron storage protein: the role of ferritin in immunity and autoimmunity. J Autoimmun. 2008;30:84-89.

  7. Cohen LA, Gutierrez L, Weiss A, Leichtmann-Bardoogo Y, Zhang DL, Crooks DR, et al. Serum ferritin is derived primarily from macrophages through a nonclassical secretory pathway. Blood. 2010;116:1574-1584.

  8. Zacharski LR, Ornstein DL, Woloshin S, Schwartz LM. Association of age, sex, and race with body iron stores in adults: Analysis of NHANES III data. Am Heart J. 2000;140:98-104.

  9. Demirkol D, Yildizdas D, Bayrakci B, Karapinar B, Kendirli T, Koroglu TF, et al. Hyperferritinemia in the critically ill child with secondary hemophagocyticlymphohistiocytosis/sepsis/multiple organ dysfunction syndrome/macrophage activation syndrome: what is the treatment? CritCare. 2012;16:R52.

  10. Orbach H, Zandman-Goddard G, Amital H, Barak V, Szekanecz Z, Szucs G, et al. Novel biomarkers in autoimmune diseases: prolactin, ferritin, vitamin D, and TPA levels in autoimmune diseases. Ann NY Acad Sci. 2007;1109:385-400.

  11. Bennett TD, Hayward KN, Farris RW, Ringold S, Wallace CA, Brogan TV. Very high serum ferritin levels are associated with increased mortality and critical care in pediatric patients. Pediatr Crit Care Med. 2011;12:233-236.

  12. Morikawa K, Oseko F, Morikawa S. H- and L-rich ferritins suppress antibody production, but not proliferation, of human B lymphocytes in vitro. Blood. 1994;83:737-743.

  13. Gray C, Franco A, Arosio P, Hersey P. Immunosuppressive effects of melanoma derived heavy chain ferritin are dependent on stimulation of IL-10 production. Int J Cancer. 2001;92:843-850.

  14. Li R, Luo C, Mines M, Zhang J, Fan G. Chemokine CXCL12 induces binding of ferritin heavy chain to the chemokine receptor CXCR4, alters CXCR4 signaling, and induces phosphorylation and nuclear translocation of ferritin heavy chain. J Biol Chem. 2006;281:37616-37627.

  15. Wang W, Knovich MA, Coffman LG, Torti FM, Torti SV. Serum ferritin: past, present and future. Biochim Biophys Acta. 2010;1800:760-769.

  16. Cohen L, Gutierrez L, Weiss A, Leichtmann Y, Zhang D, Crooks D, et al. Serum ferritin is derived primarily from macrophages through a nonclassical secretory pathway. Blood. 2010;116:1574-1584.

  17. Cozzi A, Corsi B, Levi S, Santambrogio P, Biasiotto G, Arosio P. Analysis of the biologic functions of H- and L-ferritins in HeLa cells by transfection with siRNAs and cDNAs: evidence for a proliferative role of L-ferritin. Blood. 2004;103:2377-2383.

  18. Mewar D, Moore D, Young S, Bertolaccini M, Khamashta M, Watson P, et al. Antiferritin antibodies discovered by phage display expression cloning are associated with radiographic damage in rheumatoid arthritis. Arthritis Rheum. 2005;52:3868-3872.

  19. Meyers J, Sabatos C, Chakravarti S, Kuchroo V. The TIM gene family regulates autoimmune and allergic diseases. Trends Mol Med. 2005;11:362-369.

  20. Recalcati S, Invernizzi P, Arosio P, Cairo G. New functions for an iron storage protein: the role of ferritin in immunity and autoimmunity. J Autoimmun. 2008;30:84-89.

  21. Chong BF, Mohan C. Targeting the CXCR4/CXCL12 axis in systemic lupus erythematosus. Expert Opin Ther Targets. 2009;13:1147-1153.

  22. Janka GE. Familial and acquired hemophagocyticlymphohistiocytosis. Annu Rev Med. 2012;63:233-246.

  23. Atteritano M, David A, Bagnato G, Beninati C, Frisina A, Laria C, et al. Haemophagocytic syndrome in rheumatic patients. A systematic review. Eur Rev Med Pharmacol Sci. 2012;16:1414-1424.

  24. Janka GE. Hemophagocytic syndromes. Blood Rev. 2007;21:245-253.

  25. Schneider EM, Lorenz I, Müller-Rosenberger M, Steinbach G, Kron M, Janka-Schaub GE. Hemophagocytic lymphohistiocytosis is associated with deficiencies of cellular cytolysis but normal expression of transcripts relevant to killer-cell-induced apoptosis. Blood. 2002;100:2891-2898.

  26. Ravelli A, Magni-Manzoni S, Pistorio A, Besana C, Foti T, Ruperto N, et al. Preliminary diagnostic guidelines for macrophage activation syndrome complicating systemic juvenile idiopathic arthritis. J Pediatr. 2005;146:598-604.

  27. Janka GE. Familial and acquired hemophagocytic lymphohistiocytosis. Eur J Pediatr. 2007;166:95-109.

  28. Efthimiou P, Paik PK, Bielory L. Diagnosis and management of adult onset Still’s disease. Ann Rheum Dis. 2006;65:564-572.

  29. Uppal SS, Al-Mutairi M, Hayat S, Abraham M, Malaviya A. Ten years of clinical experience with adult onset Still’s disease: is the outcome improving? Clin Rheumatol. 2007;26:1055-1060.

  30. Mathieu GV, Jamilloux Y, Iwaz J, Sève P. Adult-onset Still’s disease. Autoimmunity Rev. 2014;13:708-722.

  31. Mavragani CP, Spyridakis EG, Koutsilieris M. Adult-onset Still’s disease: from pathophysiology to targeted therapies. Int J Inflamm. 2012;879-890.

  32. Fautrel B, Le Moel G, Saint-Marcoux B, Taupin P, Vignes S, Rozenberg S, et al. Diagnostic value of ferritin and glycosylated ferritin in adult onset Still’s disease. J Rheumatol. 2001;28:322-329.

  33. Yamaguchi M, Ohta A, Tsunematsu T, Kasukawa R, Mizushima Y, Kashiwagi H, et al. Preliminary criteria for classification of adult Still’s disease. J Rheumatol. 1992;19:424-430.

  34. Fujii T, Nojima T, Yasuoka H, Satoh S, Nakamura K, Kuwana M, et al. Cytokine and immunogenetic profiles in Japanese patients with adult Still’s disease. Association with chronic articular disease. Rheumatology. 2001;40:1398-1404.

  35. Kato T, Kobayashi T, Nishino H, Hidaka Y. Double-filtration plasmapheresis for resolution of corticosteroid resistant adult onset Still’s disease. Clin Rheumatol. 2006;25:579-582.

  36. Choi JH, Suh CH, Lee YM, Suh YJ, Lee SK, Kim SS, Nahm DH, Park HS. Serum cytokine profiles in patients with adult onset Still’s disease. J Rheumatol. 2003;30:2422-2427.

  37. Rau M, Schiller M, Krienke S, Heyder P, Lorenz H, Blank N. Clinical manifestations but not cytokine profiles differentiate adult-onset Still’s disease and sepsis. J Rheumatol. 2010; 37:2369-2376.

  38. Lee SJ, Cho YN, Kim TJ, Park SC, Park DJ, Jin HM, et al. Natural killer T cell deficiency in active adult-onset Still’s Disease: correlation of deficiency of natural killer T cells with dysfunction of natural killer cells. Arthritis Rheum. 2012;64:2868-2877.

  39. Castillo L, Carcillo J. Secondary hemophagocytic lymphohistiocytosis and severe sepsis/systemic inflammatory response syndrome/multiorgan dysfunction syndrome/macrophage activation syndrome share common intermediate phenotypes on a spectrum of inflammation. Pediatr Crit Care Med. 2009;10:387-392.

  40. Moller H, Moestrup S, Weis N, Wejse C, Nielsen H, Pedersen S. Macrophage serum markers in pneumococcal bacteremia: prediction of survival by soluble CD163. Crit Care Med. 2006;34:2561-2566.

  41. Sciascia S, Lopez-Pedrera C, Roccatello D, Cuadrado M. Catastrophic antiphospholipid syndrome (CAPS). Best Pract Res Clin Rheumatol. 2012;26:535-541.

  42. Cervera R, Bucciarelli S, Plasin M, Gomez-Puerta J, Plaza J, Pons-Estel G. Catastrophic antiphospholipid syndrome (CAPS) registry project group (European forum on antiphospholipid antibodies: catastrophic antiphospholipid syndrome (CAPS): descriptive analysis of a series of 280 patients from the “CAPS Registry”. J Autoimmun. 2009;32:240-245.

  43. Cervera R. Update on the diagnosis, treatment, and prognosis of the catastrophic antiphospholipid syndrome. Curr Rheumatol Rep. 2010;12:70-76.

  44. Espinosa G, Bucciarelli S, Cervera R, Gomez-Puerta J, Font J. Laboratory studies on pathophysiology of the catastrophic antiphospholipid syndrome. Autoimmun Rev. 2006;6:68-71.

  45. Asherson R. The catastrophic antiphospholipid (Asherson’s) syndrome in 2004 - a review. Autoimmun Rev. 2005;4:48-54.

  46. Garcia P, Longhi F, Branco R, Piva J, Lacks D, Tasker R. Ferritin levels in children with severe sepsis and septic shock. Acta Paediatr. 2007;96:1829-183.

  47. Dellinger RP, Levy MM, Carlet JM, Bion J, Parker MM, Jaeschke R. Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008. Crit Care Med. 2008;36(1):296-327.

  48. Cinel I, Opal S. Molecular biology of inflammation and sepsis: a primer. Crit Care Med. 2009;37:291-304.

  49. Gogos CA, Drosou E, Bassaris H, Skoutelis A. Pro-versus anti-inflammatory cytokine profile in patients with severe sepsis: a marker for prognosis and future therapeutic options. J Infect Dis. 2000;181:176-180.

  50. Lvovschi V, Arnaud L, Parizot C, Freund Y, Juillien G, Ghillani-Dalbin P. Cytokine profiles in sepsis have limited relevance for stratifying patients in the emergency department: a prospective observational study. PLoS One. 2011;6:e28870.




2020     |     www.medigraphic.com