2014, Número 3
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Ann Hepatol 2014; 13 (3)
Antioxidant effect of N-acetylcysteine on prehepatic portal hypertensive gastropathy in rats
Licks F, Marques C, Zetler C, Morgan MMI, Marroni CA, Marroni NP
Idioma: Ingles.
Referencias bibliográficas: 29
Paginas: 370-377
Archivo PDF: 138.89 Kb.
RESUMEN
Sin resumen.
REFERENCIAS (EN ESTE ARTÍCULO)
Bosh J, Berzigotti A, Garcia-Pagan JC, Abraldes, J. The management of portal hypertension: Rational basis, available treatments and future options. J Hepatol 2008; 48: S68-S92.
Sikuler E, Kravetz D, Groszmann RJ. Evolution of portal hypertension and mechanisms involved in its maintenance in a rat model. Am J Physiol 1985; 248: G618-G625.
Abraldes JG, Pasarín M, Garcia-Pagan JC. Animal models of portal hypertension. World J Gastroenterol 2006; 12: 6577-84.
Marley R, Holt S, Fernando B, Harry D, Anand R, Goodier D, Davies S, et al. Lipoic acid prevents development of the hyperdinamic circulation in anesthetized rats with biliary cirrhosis. Hepatology 1999;29: 1358-63.
Seckin Y, Harputluoglu MM, Batcioglu K, Karincaoglu M, Yildirim B, Oner RI, Uyumlu B, et al. Gastric tissue oxidative changes in portal hypertension and cirrhosis. Dig Dis Sci 2007; 52: 1154-8.
Ohta M, Tanoue K, Tarnawski AS, Pai R, Itani RM, Sander FC, Sugimachi K, et al. Overexpressed nitric oxide synthase in portal-hypertensive stomach of rat: a key to increased susceptibility to damage? Gastroenterology 1997; 112: 1920-30.
Failli P, Palmieri L, D’Alfonso C, Giovannelli L, Generini S, Rosso AD, Pignone A, et al. Effect of N-acetyl-Lcysteine on peroxynitrite and superoxide anion production of lung alveolar macrophages in systemic sclerosis. Nitric Oxide 2002; 7: 277-82.
Halpern BN, Pacaud A. Technique of obtaining blood samples from small laboratory animals by puncture of ophthalmic plexus. C R Seances Soc Biol Fil 1951; 145: 1465-6.
AVMA Guidelines for the euthanasia of animals 2013; 231:1-102.
Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976; 72: 248-54.
Buege JA, Aust SD. Microsomal Lipid Peroxidation. Methods Enzymol 1978; 52: 302-10.
Granger DL, Anstey NM, Miller WC, Weinberg JB. Measuring nitric oxide production in human clinical studies. Methods Enzymol 1999; 301: 49-61.
Mirsa HP, Fridovich I. The role of superoxide anion in the autoxidation of epinephrine and a simple assay for superoxide dismutase. J Biol Chem 1972; 247: 3170-5.
Flohe L, Gunzler WA. Assays of glutathione peroxidase. Methods Enzymol 1984; 105: 114-21.
Colle I, Geerts AM, Van-Steenkiste C, Vlierbergue Hans-Van. Hemodynamic Changes in Splanchnic Blood Veseels in Portal Hypertension. Anat Rec (Hoboken) 2008; 291: 699-13.
Al-Busafi SA, McNabb-Baltar J, Farag A, Hilzenrat N. Clinical manifestations of portal hypertension. Int J Hepatol 2012; 2012: 203794.
Novo E, Parola M. Redox mechanisms in hepatic chronic wound healing and fibrogenisis. Fibrogenesis Tissue Repair 2008; 1: 5.
Moreira AJ, Fraga C, Alonso M, Collado P, Zetler C, Marroni NP. Quercetin prevents oxidative stress and NF-kappaB activation in gastric mucosa of portal hypertensive rats. Biochem Pharmacol 2004; 68: 1939-46.
Langer D, Shan V. Nitric oxide and portal hypertension: interface of vasoreactivity and angiogenesis. J Hepatol 2006; 44: 209-16.
Vorobioff J, Bredfeldt JE, Groszmann RJ. Hyperdynamic circulation in portal-hypertensive rat model: a primary factor for maintenance of chronic portal hypertension. Am J Physiol 1983; 244: G52-G57.
Marques C, Mauriz JL, Simonetto D, Marroni CA, Tuñon MJ, Marroni NP, González-Gallego J. Glutamine prevents gastric oxidative stress in an animal model of portal hypertension gastropathy. Ann Hepatol 2011; 10: 531-9.
Fernando B, Marley R, Holt S, Anand R, Harry D, Sanderson P, Smith R, et al. N-Acetiylcysteine Prevents Development of the Hyperdinamic Circulation in the Portal Hypertensive Rat. Hepatology 1998; 28: 689-94.
Millea PJ. N-Acetylcysteine: Multiple Clinical Applications. Am Fam Physician 2009; 80: 265-9.
Bémeur C, Vaquero J, Desjardins P, Butterworth RF. Nacetylcysteine attenuates cerebral complications of nonacetaminophen- induced acute liver failure in mice: antioxidant and anti-inflammatory mechanisms. Metab Brain Dis 2010; 25: 241-9.
Sabra R, Shuman S. Influence of Phenobarbital on changes in Na handling, hemodynamics and liver function due to portal vein ligation in rats. Eur J Pharmacol 2001; 413: 287-94.
Lopez-Belmonte J, Whittle BJR, Moncada S. The actions of nitric oxide donors in the prevenction or induction of injury to the rat gastric mucosa. Br J Pharmacol 1993; 108: 73-8.
Hodgson EK, Fridovich I. The interaction of bovine erythrocyte superoxide dismutase with hydrogen peroxide: inactivation of the enzyme. Biochemistry 1975; 14: 5294-9.
Blum J, Fridovich I. Inactivation of glutathione peroxidase by superoxide radical. Arch Biochem Biophys 1985; 240: 500-8.
Pastor A, Collado PS, Almar M, González-Gallego J. Antioxidant enzyme status in biliary obstructed rats: effects of N-acetylcysteine. J Hepatol 1997; 27: 363-70.