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2015, Número 1

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Gac Med Mex 2015; 151 (1)


Uso de nanopartículas (NP) en la terapia fotodinámica (photodynamic therapy [PDT]) contra el cáncer

Roblero-Bartolón GV, Ramón-Gallegos E

Idioma: Español
Referencias bibliográficas: 102
Paginas: 85-98
Archivo PDF: 442.35 Kb.


RESUMEN

La nanotecnología es un campo interdisciplinario prometedor en el desarrollo de mejores métodos de diagnóstico y tratamiento en diferentes enfermedades, entre ellas el cáncer. Debido a las propiedades ópticas, magnéticas y estructurales de las NP, se ha propuesto su uso en el desarrollo de tratamientos no convencionales contra el cáncer, como la PDT. En la PDT se utiliza un agente fotosensibilizador (PS) que se acumula en las células tumorales y causa la muerte de las células malignas después de la irradiación con luz a una determinada longitud de onda. Sin embargo, el uso de la PDT presenta diferentes problemas en su aplicación debido a las características de hidrofobicidad de los PS que dificultan la administración y eficiencia del tratamiento, razón por la cual se propone el uso de NP como vehículos de transporte y su acoplamiento a PS para optimizar la aplicación del tratamiento. En esta revisión se describe el uso de las NP en la PDT en el tratamiento contra el cáncer, sus características y su mecanismo de acción molecular al ser acopladas a un PS.


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