Barañao RI

Idioma: Español
Referencias bibliográficas: 44
Paginas: 755-763
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RESUMEN

La endometriosis es una afección inflamatoria dependiente de estrógenos que se caracteriza por la coexistencia de tejido endometrial fuera de la cavidad uterina. Los síntomas más comunes de la endometriosis son el dolor pélvico y la infertilidad. El dolor intenso puede afectar la calidad de vida de la mujer. Aproximadamente 10% de las mujeres en edad reproductiva tienen endometriosis. El principal objetivo de este trabajo es exponer las alteraciones del sistema inmunológico en pacientes con endometriosis que impiden la eliminación del tejido endometrial ectópico. Se describen algunas de las alteraciones en los distintos tipos de leucocitos, citocinas y factores reguladores de la respuesta inmunológica coexistentes en pacientes con endometriosis y los mecanismos por los que estas alteraciones no sólo favorecen la “tolerancia inmunológica” hacia los implantes endometriósicos sino que, por el contrario, favorecen la progresión de la enfermedad al estimular la proliferación y angiogénesis e inhibir la apoptosis del tejido endometrial ectópico.

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