2014, Número 6
Estudio de los polimorfismos R353Q en el gen del factor VII de la coagulación y el N700S en el gen de la trombospondina-1 en pacientes jóvenes mexicanos con infarto agudo de miocardio
Valades-Mejía MG, Domínguez-López ML, Aceves-Chimal JL, Leaños-Miranda A, Majluf-Cruz A, Isordia-Salas I
Idioma: Español
Referencias bibliográficas: 39
Paginas: 595-606
Archivo PDF: 522.13 Kb.
RESUMEN
Antecedentes: el infarto agudo de miocardio es la principal causa de
morbilidad y mortalidad en el mundo, y resulta de la combinación de
factores modificables y genéticos. Se ha propuesto que el polimorfismo
R353Q en el gen del factor VII de la coagulación representa un
factor protector en contra del infarto agudo de miocardio, mientras
que el polimorfismo N700S en el gen de la trombospondina-1 (TSP-
1) incrementa el riesgo; sin embargo, los resultados aún suscitan
controversia.
Objetivo: determinar la posible asociación de los polimorfismos R353Q
y del N700S con el infarto agudo de miocardio en pacientes mexicanos
menores de 45 años.
Material y métodos: estudio de casos y controles que incluyó 252
pacientes con diagnóstico de infarto agudo de miocardio y 252
individuos aparentemente sanos sin antecedentes de enfermedad
coronaria, pareados por edad y sexo. Los polimorfismos R353Q N700S
se determinaron en todos los participantes por medio de PCR-RFLP.
Resultados: no se observó diferencia estadística en la distribución
genotípica del polimorfismo R353Q del FVII entre los grupos con
infarto agudo de miocardio y el grupo control (
p = 0.06). Se encontró
una distribución genotípica similar del polimorfismo N700S en
ambos grupos (
p = 0.50). Se identificaron como factores de riesgo
independiente para infarto agudo de miocardio: hipertensión arterial,
diabetes mellitus, antecedentes heredofamiliares para enfermedad
coronaria y dislipidemia.
Conclusiones: los polimorfismos R353Q y N700S no representan un
factor protector o de riesgo, respectivamente, para infarto agudo de
miocardio en pacientes jóvenes mexicanos.
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