2014, Número 2
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Arch Neurocien 2014; 19 (2)
Desarrollo de la vía dopaminérgica nigroestriatal
Gómez-Chavarín M, Santos-Echeverria R, García-García M, Torner-Aguilar C, Báez-Saldaña A
Idioma: Español
Referencias bibliográficas: 62
Paginas: 95-103
Archivo PDF: 265.98 Kb.
RESUMEN
Los circuitos neuronales cerebrales al nacimiento son inmaduros; se refinan progresivamente por mecanismos
intrínsecos, por los efectos que ejercen los factores del microambiente. Estos circuitos inmaduros tienen capacidad
plástica, son vulnerables al impacto de factores externos o ambientales que pueden alterar su funcionalidad y
resultar en la expresión de circuitos disfuncionales que pueden manifestarse en conductas aberrantes asociadas a
patologías. En particular, las alteraciones funcionales de los ganglios basales pueden originar manifestaciones
conductuales de algunas patologías neuropsiquiátricas. La anatomía y funcionamiento de circuitos corticoestriatales
son conocidos en el animal adulto, pero ¿existe evidencia de que su madurez se completa en etapas tardías
del desarrollo posnatal?
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