Suárez MR, Martínez LJP, Molinero RC, Prada HD

Idioma: Español
Referencias bibliográficas: 31
Paginas:
Archivo PDF: 84.54 Kb.

RESUMEN

La relación que existe entre las espondiloartritis y la infección intestinal ha sido observada de forma regular existiendo múltiples reportes de casos que refieren esta asociación clínica; en su etiología se mencionan bacterias como Shigella, Yersinia, Campylobacter o Salmonella presentes en el sistema digestivo de estos enfermos que secundariamente desarrollan un cuadro inflamatorio enteso-articular. Estos procesos morbosos puede concomita desde un inicio o demorar algunos años en relacionarse, la concordancia más importante entre ambos trastornos se da en el contexto de las espondiloartritis de las enfermedades inflamatorias intestinales crónicas, reportándose también asociada con la espondilitis anquilosante, artritis reactivas y artritis psoriásica, confirmando la participación del intestino en estas entidades. En esta revisión exponemos los avances más recientes de la relación que se presenta entre las infecciones del intestino y la patogenia de la espondilitis anquilosante, así como de otras enfermedades que componen el grupo de las espondiloartritis.

REFERENCIAS (EN ESTE ARTÍCULO)

1. Brewerton DA, Hart FD, Nicholls A, Caffrey M, James DC, SturrockRD.Ankylosingspondylitis and HL-A 27. Lancet. 1973;1:904-7.

2. Collantes Estévez E. El intestino en la patogenia de las espondiloartritis. Reumatol. Clin. 2007; 3 Supl 2: S29-32

3. Ciccia F, et al. Overexpression of Interleukin-23, but Not Interleukin-17, as an Immunologic Signature of Subclinical Intestinal Inflammation in Ankylosing Spondylitis. Arthritis & Rhreumatims. 2009; 60 (4): 955-965.

4. Plevy SE, Landers CJ, Prehn J, Carramanzana NM, Deem RL, Shealy D, et al. A role for TNFand mucosal T helper-1 cytokines in the pathogenesis of Crohn’s disease. J Immunol 1997; 159: 6276–82.

5. Leirisalo-Repo M. Prognosis, course of disease, and treatment of thespondyloarthropathies. Rheumatic Dis Clin N Amer. 1998; 24: 737- 51.

6. Rosenbaum JT, Davey MP. Time for a Gut Check: Evidence for the Hypothesis That HLA–B27 Predisposes to Ankylosing Spondylitis by Altering the Microbiome. Arthritis & Rheumatims. 2011; 63, (11): 3195– 3198.

7. Rashid, T. Ebringer, A. Ankylosing spondylitis is linked to Klebsiella–– the evidence. Clin.Rheumatol. 2007; 26: 858–864.

8. Hannu, T., inman, R., Granfors, K, Leirisalo-Repo, M. Reactive arthritis or post-infectious arthritis? Best Pract. Res. Clin. Rheumatol. 2006; 20: 419–433.

9. Koehler L, Kuipers J.G, Zeigler H. Managing seronegative spondyloarthritides. Rheumatology. 2000; 39:360-368.

10. Parronchi P, Romagnani P, Annunziato F, Sampognaro S, Becchio A, Giannarini L, et al. Type 1 T-helper cell predominance and interleukin- 12 expression in the gut of patients with Crohn’s disease. Am J Pathol 1997; 150: 823-832.

11. Romagnani S. The Th1/Th2 paradigm. Immunol Today 1997; 18: 263–6.

12. Bettelli E, Oukka M, Kuchroo VK. T(H)-17 cells in the circle of immunity and autoimmunity. Nat Immunol 2007; 8: 345–50.

13. Costa-Rodriguez EV, Napolitani G, Lanzavecchia A, Sallusto F. Interleukins 1 and 6 but not transforming growth factor are essential for the differentiation of interleukin 17-producing human T helper cells. Nat Immunol 2007; 8: 942–9.

14. Mielants H, Veys EM, Cuvelier C, de Vos M. Ileocolonoscopic findings in seronegative spondylarthropathies. Br J Rheumatol 1988;27 Suppl 2:95– 105.

15. Rudwaleitt M, Baeten D. Ankylosing spondylitis and bowel disease. Best Practice and Research Clin Rheeum. 2006; 3: 451-71.

16. Ciccia F, Accardo-Palumbo A, Giardina A et al. Intestinal CD4 (+) CD25 (high) regulatory T cells are expanded in ankylosing spondylitis patients: a putative role for IL-10 in preventing intestinal TH17 response. Arthritis Rheum 2010; 62:3625-34.

17. van Limbergen J, Wilson DC, Satsangi J. The genetics of Crohn’s disease. Ann Rev Genomics Hum Genet 2009; 10: 89-116.

18. Acheson DWK, Luccioli S. Mucosal immune responses. Best Pr Res Cli Gast. 2004; 18: 387-404.

19. Hill Gaston JS. Host-infectious agent interactions in the patogenesis of rheumatic disease. Cur Op Rheumatology2004; 16:371-3.

20. Hawrelak JA, Myers SP. The causes of intestinal dysbiosis: A review. Alt Med Rev. 2004; 9: 180-94.

21. Smith JA, Marker-Herman E, Colbert RA. Pathogenesis of ankylosing spondylitis. Current concepts. Best Pract Res Clin Rheum. 2006; 3: 571- 91.

22. Rudwaleit M, Baeten D. Ankylosing spondylitis and bowel disease. Best Pract Res Clin Rheumatol 2006;20: 451–71.

23. YeremenkoN, Baeten D. IL-17 in spondyloarthritis: is the T-party over? .Arthritis Research & Therapy 2011, 13:115.

24. Bettelli E, Carrier Y, Gao W, Korn T, Strom TB, Oukka M, et al. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature 2006;441:235–8.

25. Di Meglio P, Di Cesare A, Laggner U, Chu CC, et al. The IL-23R R381Q gene variant protects against immune-mediated diseases by impairing IL- 23-induced Th17 effector response in humans. PLoS One 2011, 6:17160.

26. Sarin R, Wu X, Abraham C: Infl ammatory disease protective R381Q IL23 receptor polymorphism results in decreased primary CD4+ and CD8+ human T cell functional responses. Proc Natl Acad Sci U S A2011, 108: 9560-9565.

27. DeLay ML, Turner MJ, Klenk EI, Smith JA, Sowders DP, Colbert RA: HLA-B27 misfolding and the unfolded protein response augment interleukin-23 production and are associated with Th17 activation in transgenic rats. Arthritis Rheum 2009, 60:2633-2643.

28. Baeten D, Sieper J, Emery P, Braun J, et al The anti-IL17A monoclonal antibody secukinumab (AIN457) showed good safety and effi cacy in the treatment of active ankylosing spondylitis. Arthritis Rheum 2010, 62: 2840-2841.

29. Khan M A. Ankylosing spondylitis and related spondyloarthropathies: the dramatic advances in the past decade Difficulties of diagnosis: how far has AS advanced? Rheumatology 2011; 50: 637-639.

30. Hammer RE, Marka SD, Ricardson JA, et al. Spontaneous infllmatory disease in transgenic rats expressing HLA-B27 and humanbetha 2 microglulin: an animal model of HLA-B27-associated human disorders. Cell. 1990; 63:109-12.

31. Sieper J, Braum J, Rutwaleit M, Boone A, Zink A. Ankylosing Spndylitis: an overview. Ann. Rheum. Diss. 2001; 61:367-11