2014, Número 3
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Rev Fac Med UNAM 2014; 57 (3)
Bases moleculares de la sepsis
Carrillo ER, Tapia JJ, Peña PCA, Kim KMJ, Jaime LÁR, Montalvo JEE
Idioma: Español
Referencias bibliográficas: 59
Paginas: 9-21
Archivo PDF: 455.99 Kb.
RESUMEN
La sepsis es un síndrome que continúa siendo una causa
importante de morbilidad y mortalidad entre los pacientes
críticamente enfermos. Pese al desarrollo de la investigación
básica dedicada al tema y los numerosos ensayos clínicos,
no se han logrado avances notables en el desarrollo de terapias
vanguardistas y eficaces para su manejo. Los trastornos
fisiológicos inducidos por la sepsis son en gran parte
debidos a la respuesta del huésped a los microorganismos
invasores en contraste con los efectos directos del propio
microorganismo.
La sepsis, entendida como la respuesta inflamatoria sistémica
a la infección, está marcada por la producción desregulada
de citocinas proinflamatorias. Estos mediadores conducen
de manera colectiva a la insuficiencia orgánica múltiple, y en
última instancia, a la muerte. Es en este sentido que el papel
de la inflamación en la fisiopatogenia de la sepsis, aunque
todavía no entendida completamente, resulta claramente crítico.
Esta revisión proporciona una perspectiva de las diversas
interacciones moleculares que ocurren durante la sepsis, con
el intento de poder comprender la naturaleza de la respuesta
desregulada del sistema inmunitario durante ésta.
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