medigraphic.com
ISSN 2305-7939 (Digital)

2013, Número 1

<< Anterior Siguiente >>

RCU 2013; 2 (1)


Papilomavirus humano, su asociación a lesiones Anogenitales en el hombre

Ríos HMÁ, Hernández MM, Bouzó LA

Idioma: Español
Referencias bibliográficas: 37
Paginas: 81-94
Archivo PDF: 366.51 Kb.


RESUMEN

Introducción: los cánceres anogenitales, así como sus lesiones precursoras, están fuertemente asociadas a la infección por Papilomavirus humano (VPH). La prevalencia a nivel mundial de estos virus, en hombres sin lesiones clínicamente visibles ha sido reportada hasta en un 73 %. La incidencia de la verruga genital presenta una tendencia creciente a nivel mundial. La frecuencia de aparición de los cánceres de pene y anal fue cerca del 50 % y del 80-85 % respectivamente. Objetivos: abordar la prevalencia de los VPH, lesiones asociadas a la infección por estos virus en el tracto anogenital masculino, así como la acción de la circuncisión y el uso del condón en la prevención de dichas lesiones. Resultados: los VPH 16 y 18 fueron los tipos más frecuentes en lesiones pre-malignas y malignas, los genotipos 6 y 11 se comportaron de la misma manera en las verrugas ano-genitales. La circuncisión y el uso del condón mostraron un papel protector tanto para la adquisición de la infección por VPH en hombres como la aparición de lesiones en el tracto anogenital femenino asociadas a estos virus. Conclusiones: existe una fuerte asociación entre los VPH y la aparición de lesiones benignas, pre-malignas y malignas en el tracto anogenital masculina.


REFERENCIAS (EN ESTE ARTÍCULO)

  1. Giuliano AR, Tortolero-Luna G, Ferrer E, Burchell AN, de Sanjose S, Kjaer SK, et al. Epidemiology of human papillomavirus infection in men, cancers other than cervical and benign conditions. Vaccine. 2008;26:17-28.

  2. Bleeker MCG, Hogewoning CJA, Berkhof J, Voorhorst FJ, Hesselink AT, van Diemen PM, et al. Concordance of specific human papillomavirus types in sex partners is more prevalent than would be expected by chance and is associated with increased viral loads. Clinical infectious diseases. 2005;41(5):612-20.

  3. Dunne EF, Nielson CM, Stone KM, Markowitz LE, Giuliano AR. Prevalence of HPV Infection among Men: A Systematic Review of the Literature. J Infect Dis 2006;194:1044-57.

  4. Giuliano AR, Nielson CM, Flores R, Dunne EF, Abrahamsen M, Papenfuss MR, et al. The optimal anatomic sites for sampling heterosexual men for human papillomavirus (HPV) detection: the HPV detection in men study. J Infect Dis 2007;196(8):1146-52.

  5. Weaver BA, Feng Q, Holmes KK, Kiviat N, Lee SK, Meyer C, et al. Evaluation of genital sites and sampling techniques for detection oh human papillomavirus DNA in men. J Infect Dis 2004;189(4):677-85.

  6. Dinh TH, Stenberg M, Dunne EF, Markowitz LE, Genital warts among 18 to 59 year olds in the United States, national health and nutrition examination survey, 1999 2004. Sex Transm Dis 2008 Apr;35(4):357-60.

  7. Kjaer SK, Tran TN, Sparen P, Tryggvadottir I, Munk C, Dasbach E, et al. The burden of genital warts: a study of nearly 70 000 women from the general female population in the four Nordic countries. J Infect Dis 2007;196(10):1447-54.

  8. Gall SA, Female genital warts: global trends and treatments. Infect Dis Obstet Gynecol 2001;9(3):149-54.

  9. Health Protection Agency. Health Protection Agency, UK 2008AprilAvailable at. http//www.hpa-org.uk/ (last accessed: April 2008).

  10. Lacey CJ, Lowndes CM, Shah KV, Chapter 4: Burden and management of non-cancerous HPV related conditions: HPV 6/11 disease. Vaccine2006 aug21;24(Suppl 3):535-41.

  11. Chin-Hong PV, Vittinghoff E, Cranston RD, Browne L, Buchbinder S, Colfax G et al. Age-related prevalence of anal cancer precursors in homosexual men: the EXPLORE study. J Natl Cancer Inst. 2005;97:896-905.

  12. Friis S, Kjaer SK, Frisch M, Mellemkjaer L, Olsen JH. Cervical intraepithelial neoplasia, anogenital cancer, and other cancer types in women after hospitalization for condylomata acuminate. J Infect Dis 1997;175(4):743-8.

  13. Insinga RP, Dasbach EJ, Myers ER. The health and economic burden of genital warts in a set of private healths plans in the United States. Clin Infect dis2003;36(11):1397-403.

  14. Insinga RP, Dasbach EJ, Elbasha EH. Assessing the annual economic burden of preventing and treating anogenital human papillomavirus-related disease in US: analytic framework and review of the literature. Pharmacoeconomic 2005;23(11):1107-22.

  15. Daling JR, Madeleine MM, Johnson LG, Schwartz SM, Shera KA, Wurscher MA, et al. Human papillomavirus, smoking and sexual practices in the etiology of anal cancer. Cancer2004;101(2):270-80.

  16. IARC. Human Papillomavirus. IARC Monographs on the Evaluation of carcinogenic risk to humans. Vol.90 Lyon: IARC Press, 2007.

  17. Varnai AD, Bollmann M, Griefingholt H, Speich N, Schmitt C, Bollmann R, et al. HPV in anal squamous cell carcinoma and anal intraepithelial neoplasia (AIN). Impact of HPV analysis of anal lesions on diagnosis and prognosis. Int J Colorectal Dis 2006;21(2):135-42.

  18. IARC. Cancer Incidence in Five Continents. Vol. IX IARC Scientific Publications No. 160 Lyon: IARC, 2007.

  19. Krustrup D, Jensen HL, van den Brule AJ, Frisch M. Histological characteristics of human papilloma-virus-positive and -negative invasive and in situ squamous cell tumours of the penis. Int J Exp Pathol. 2009 Apr;90(2):182-9.

  20. Favorito LA, Nardi AC, Ronalsa M, Zequi SC, Sampaio FJ, Glina S. "Epidemiologic study on penile cancer in Brazil. Int Braz J Urol. 2008 Sep-Oct;34(5):587-91.

  21. Madsen BS, van den Brule AJ, Jensen HL, Wohlfahrt J, Frisch M. "Risk factors for squamous cell carcinoma of the penis—population-based case-control study in Denmark "Cancer Epidemiol Biomarkers Prev. 2008 Oct;17(10):2683-91.

  22. Morris BJ. La Circuncisión : Una vieja protección compulsoria. HPV Today. www.hpvtoday.com. 21. Stephen S. Sternberg. Diagnostic Surgical Pathology . Third Edition Vol 2. Lippincott Williams & Wilkins 1999. 22. Kyo S, Inoue M, Koyama M, Fujita M, Tanizawa O, Hakura A. Detection of high-risk human papillomavirus in the cervix and semen of sex partners. J Infect Dis 1994;170(3):682-5.

  23. Campion MJ, Singer A, Clarkson PK, McCance DJ. Increased risk of cervical neoplasia in consorts of men with penile condylomata acuminate. Lancet 1985;1(8435):943-6.

  24. Patridge JM, Hughes JP, Feng Q, Winer RL, Weave BA, Xi LF et al. Genital human papillomavirus infection in men: incidence and risk factors in a cohort of university students. J Infect Dis 2007;196(8):1128-36.

  25. Giuliano AR, Harris R, Sedjo RL, Baldwin S, Roe D, Papenfuss MR, et al. Incidence, prevalence, and clearance of type-specific human papillomavirus infection: The young women´s health study. J Infect Dis 2002;186(4):462-9.

  26. Giuliano AR, Lu B, Nielson C. Age Specific Prevalence, Incidence, and Duration of Human Papillomavirus Infections Among a Cohorte of 290 US Men. J Infect Dis 2008; in press.

  27. Van Doornum GJ, Prins M, Juffermans LH, Hooykaas C, van der Hoek JA, CoutinhoRA, et al. Regional distribution and incidence of human papillomavirus infections among heterosexual men and women with multiple sexual partners: a prospective study. Genitourin Med 1994;70(4):240-6.

  28. Giuliano AR, Lazcano E, Villa LI. Factors associates with HPV detection among men internationally : The HIM study . Abstract 8B-04 24th International Papillomavirus Conference and Clinical Workshop, Beijing, China. November 2007 (abstracts Book).

  29. Castellsague X, Bosch FX, Muñoz N, Meijer CJ, Shah KV, de Sanjose S, et al. Male circumcision, penile human papillomavirus infection, and cervical cancer in female partners. N Engl J Med 2002;346(15):1105-12.

  30. Khouadri S, Villa LL, Gagnon S, Koushik A, Richardson H, Ferreira S, et al. Human Papillomavirus type 33 polymorphims and high grade squamous intraepithelial lesions of the uterine cervix. J Infect Dis 2006;194(7):886-94.

  31. Muñoz N, Mendez F, Posso H, Molano M, van der Brule AJ, Ronderos M. Incidence, duration and determinants of cervical human papillomavirus infection in a cohort of Colombian womwn with normal cytological results. J Infect Dis 2004;190(12):2077-87.

  32. Burchell AN, Winer RL, de Sanjose S, Franco EL. Chapter 6: Epidemiology and transmission dynamics of genital HPV infection. Vaccine 2006;24 (Suppl. 3):552-61.

  33. Shin HR, Franceschi S, Vaccarella S, Roh JW, Ju YH, Oh JK, et al. Prevalence and determinants of genital infection with papillomavirus, in female and male university students in Busan, South Korea. Journal of Infectious Diseases. 2004;190(3):468-76.

  34. Auvert B, Sobngwi-Tambekou J, Cutler E, Nieuwoudt M, Lissouba P, Puren A, et al. Effect of male circumcision on the prevalence of high-risk human papillomavirus in young men: results of a randomized controlled trial conducted in Orange Farm, South Africa. Journal of Infectious Diseases. 2009;199(1):14-9. trial conducted in Orange Farm, South Africa. J Infect Dis. 2009 January ; 199(1):1419.

  35. Hernandez BY, Wilkens LR, Zhu X, McDuffie K, Thompson P, Shvetsov YB, Ning L, Goodman MT. Circumcision and human papillomavirus infection in men: a site-specific comparison. Infect Dis. 2008 Mar 15;197(6):787-94.

  36. Nielson CM, Harris RB, Nyitray, A, Dunne EF, Stone KM, A Giuliano, et al. Condom use is associated with lower HPV prevalence in men. 25th International Papillomavirus Conference, Malmö, Sweden. 2009, Libro resumen O-27.05.

  37. Chin-Hong P, Benet D, Da Costa M, Darragh T, Judson F, Koblin B, et al. Condoms prevent incident anal human papillomavirus infection in men. 25th International Papillomavirus Conference, Malmö, Sweden. 2009, Libro resumen O-27.07.




2020     |     www.medigraphic.com