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2014, Número 2

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Salud Mental 2014; 37 (2)


La liberación de calcio de los depósitos intracelulares promueve la secreción de serotonina en terminales sinápticas

Trueta C

Idioma: Español
Referencias bibliográficas: 68
Paginas: 103-110
Archivo PDF: 651.83 Kb.


RESUMEN

En este trabajo se estudió la participación que tiene la liberación de calcio del retículo endoplásmico en la liberación de serotonina en terminales sinápticas. Los experimentos se llevaron a cabo en sinapsis formadas en cultivo entre neuronas serotonérgicas de Retzius y neuronas mecanosensoriales sensibles a presión, aisladas del Sistema Nervioso Central de la sanguijuela. En esta preparación la estimulación con pares de impulsos produjo facilitación sináptica. La estabilización de los receptores de rianodina en un estado de sub-conductancia por la incubación con rianodina 100 µM produjo un alargamiento del potencial sináptico en respuesta a impulsos presinápticos, sugiriendo que el calcio liberado por estos canales puede alcanzar las vesículas y promover la secreción. En contraste, el vaciamiento de los depósitos intracelulares de calcio con tapsigargina 500 nM produjo una disminución gradual de la facilitación sináptica ante impulsos presinápticos pareados y abolió la liberación extrasináptica en el axón neuronal en respuesta a trenes de impulsos. Todo esto ocurrió sin cambios en las propiedades de la membrana postsináptica, lo cual sugiere que la liberación de calcio intracelular participa en un mecanismo de retroalimentación positiva que promueve la liberación presináptica y perisináptica en las neuronas serotonérgicas.


REFERENCIAS (EN ESTE ARTÍCULO)

  1. Livingstone MS, Harris-Warrick RM, Kravitz EA. Serotonin and octopamine produce opposite postures in lobsters. Science 1980;208:76-79.

  2. Harris-Warrick RM, Kravitz EA. Cellular mechanisms for modulation of posture by octopamine and serotonin in the lobster. J Neuroscience 1984;4(8):1976-1993.

  3. Kravitz EA. Serotonin and aggression: insights gained from a lobster model system and speculations on the role of amine neurons in a complex behavior. J Comparative Physiology. A sensory, Neural, Behavioral Physiology 2000;186(3):221-238.

  4. Raleigh MJ, McGuire MT, Brammer GL, et al. Serotonergic mechanisms promote dominance acquisition in adult male vervet monkeys. Brain Res 1991;559:181-190.

  5. Higley JD, Linnoila M. Low central nervous system serotonergic activity is traitlike and correlates with impulsive behavior. A nonhuman primate model investigating genetic and environmental influences on neurotransmission. Ann N Y Acad Sci 1997;836:39-56.

  6. Ferris CF. Adolescent stress and neural plasticity in hamsters: a vasopressin- serotonin model of inappropriate aggressive behaviour. Exp Physiol 2000;85;Spec No:85S-90S.

  7. Lesch KP, Merschdorf U. Impulsivity, aggression, and serotonin: a molecular psychobiological perspective. Behav Sci Law 2000;18:581–604.

  8. Breisch ST, Zemlan FP, Hoebel BG. Hyperphagia and obesity following serotonin depletion by intraventricular p-chlorophenylalanine. Science 1976;192:382-385.

  9. Saller CF, Stricker EM. Hyperphagia and increased growth in rats after intraventricular injection of 5,7-dihydroxytryptamine. Science 1976;192(4237):385-387.

  10. Jacobs BL, Azmitia EC. Structure and function of the brain serotonin system. Physiol Rev 1992;72:165-229.

  11. Zangrossi H Jr, Viana MB, Zanoveli J et al. Serotonergic regulation of inhibitory avoidance and one-way escape in the rat elevated T-maze. Neurosci Biobehav Rev 2001;25:637-645.

  12. Prosser RA, Miller JD, Heller HC. A serotonin agonist phase-shifts the circadian clock in the suprachiasmatic nuclei in vitro. Brain Res 1990;534:336-339.

  13. Hull EM, Lorrain DS, Du J et al. Hormone-neurotransmitter interactions in the control of sexual behavior. Behavioural Brain Research 1999;105(1):105-116.

  14. Weiger WA. Serotonergic modulation of behaviour: a phylogenetic overview. Biological Reviews Cambridge Philosophical Society 1997;72(1):61-95.

  15. McCall RB, Aghajanian GK. Serotonergic facilitation of facial motoneuron excitation. Brain Res 1979;169:11-27.

  16. Jacobs BL, Fornal CA. 5-HT and motor control: a hypothesis. Trends Neurosci 1993;16:346-352.

  17. White SR, Fung SJ, Jackson DA et al. Serotonin, norepinephrine and associated neuropeptides: effects on somatic motoneuron excitability. Prog Brain Res 1996;107:183-199.

  18. Arango V, Underwood MD, Mann JJ. Serotonin brain circuits involved in major depression and suicide. Progress Brain Research 2002;136:443-453.

  19. Jobe PC, Dailey JW, Wernicke JF. A noradrenergic and serotonergic hypothesis of the linkage between epilepsy and affective disorders. Crit Rev Neurobiol 1999;13:317-356.

  20. Brieden T, Ujeyl M, Naber D. Psychopharmacological treatment of aggression in schizophrenic patients. Pharmacopsychiatry 2002;35(3):83–89.

  21. Jenike MA, Rauch SL, Cummings JL et al. Recent developments in neurobiology of obsessive-compulsive disorder. J Clinical Psychiatry 1996;57(10):492-503.

  22. Kiehn O, Rostrup E, Møller M. Monoaminergic systems in the brainstem and spinal cord of the turtle Pseudemys scripta elegans as revealed by antibodies against serotonin and tyrosine hydroxylase. J Comp Neurol 1992;325:527-547.

  23. Alvarez FJ, Pearson JC, Harrington D et al. Distribution of 5-hydroxytryptamine- immunoreactive boutons on alpha-motoneurons in the lumbar spinal cord of adult cats. J Comp Neurol 1998;393:69-83.

  24. Moukhles H, Bosler O, Bolam JP et al. Quantitative and morphometric data indicate precise cellular interactions between serotonin terminals and postsynaptic targets in rat substantia nigra. Neuroscience 1997;76:1159-1171.

  25. Trueta C, Méndez B, De-Miguel FF. Somatic exocytosis of serotonin mediated by L-type calcium channels in cultured leech neurones. J Physiology 2003;547 Pt2:405-416.

  26. De-Miguel FF, Trueta C. Synaptic and extrasynaptic secretion of serotonin. Cell Mol Neurobiol 2005;25:297-312.

  27. Colgan LA, Putzier I, Levitan ES. Activity-dependent vesicular monoamine transporter-mediated depletion of the nucleus supports somatic release by serotonin neurons. J Neurosci Off J Soc Neurosci 2009;29:15878-15887.

  28. Kaushalya SK, Desai R, Arumugam S et al. Three-photon microscopy shows that somatic release can be a quantitatively significant component of serotonergic neurotransmission in the mammalian brain. J Neurosci Res 2008;86:3469-3480.

  29. Sarkar B, Das AK, Arumugam S et al. The dynamics of somatic exocytosis in monoaminergic neurons. Front Physiol 2012;3. Available at: http://www.frontiersin.org/Membrane_Physiology_and_Biophysics/ 10.3389/fphys.2012.00414/abstract. Accessed February 13, 2013.

  30. De Kock CPJ, Burnashev N, Lodder JC et al. NMDA receptors induce somatodendritic secretion in hypothalamic neurones of lactating female rats. J Physiol 2004;561:53-64.

  31. Chazal G, Ralston HJ 3rd. Serotonin-containing structures in the nucleus raphe dorsalis of the cat: an ultrastructural analysis of dendrites, presynaptic dendrites, and axon terminals. J Comp Neurol 1987;259:317-329.

  32. Nicholls JG, Kuffler DP. Quantal release of serotonin from presynaptic nerve terminals. Neurochem Int 1990;17:157-163.

  33. Fernández-de-Miguel F, Drapeau P. Synapse formation and function: insights from identified leech neurons in culture. J Neurobiol 1995;27:367-379.

  34. Katz B, Miledi R. The role of calcium in neuromuscular facilitation. J Physiol 1968;195:481-492.

  35. Llinas R, Sugimori M, Silver RB. Microdomains of high calcium concentration in a presynaptic terminal. Science 1992;256:677.

  36. Llinas R, Gruner, M, Sugimori M et al. Regulation by synapsin I and Ca(2+)-calmodulin-dependent protein kinase II of the transmitter release in squid giant synapse. J Physiol 1991;436:257-282.

  37. Henderson LP, Kuffler DP, Nicholls J et al. Structural and functional analysis of synaptic transmission between identified leech neurones in culture. J Physiol 1983;340:347-358.

  38. Dietzel ID, Drapeau P, Nicholls JG. Voltage dependence of 5-hydroxytryptamine release at a synapse between identified leech neurones in culture. J Physiol 1986;372:191-205.

  39. Kuffler DP, Nicholls J, Drapeau P. Transmitter localization and vesicle turnover at a serotoninergic synapse between identified leech neurons in culture. J Comp Neurol 1987;256:516-526.

  40. Stewart RR, Adams WB, Nicholls JG. Presynaptic calcium currents and facilitation of serotonin release at synapses between cultured leech neurones. J Exp Biol 1989;144:1-12.

  41. Bruns D, Riedel D, Klingauf J et al. Quantal release of serotonin. Neuron 2000;28:205-220.

  42. Pozzan T, Rizzuto R, Volpe P et al. Molecular and cellular physiology of intracellular calcium stores. Physiol Rev 1994;74:595-636.

  43. Tsien RW, Tsien RY. Calcium channels, stores, and oscillations. Annu Rev Cell Biol 1990;6:715-760.

  44. Lemmens R, Larsson O, Berggren PO et al. Ca2+-induced Ca2+ release from the endoplasmic reticulum amplifies the Ca2+ signal mediated by activation of voltage-gated L-type Ca2+ channels in pancreatic beta-cells. J Biol Chem 2001;276:9971-9977.

  45. Kang G, Holz GG. Amplification of exocytosis by Ca2+-induced Ca2+ release in INS-1 pancreatic beta cells. J Physiol 2003;546:175-189.

  46. Llano I, González J, Caputo C, et al. Presynaptic calcium stores underlie large-amplitude miniature IPSCs and spontaneous calcium transients. Nat Neurosci 2000;3:1256-1265.

  47. Emptage NJ, Reid CA, Fine A. Calcium stores in hippocampal synaptic boutons mediate short-term plasticity, store-operated Ca2+ entry, and spontaneous transmitter release. Neuron 2001;29:197-208.

  48. Simkus CRL, Stricker C. The contribution of intracellular calcium stores to mEPSCs recorded in layer II neurones of rat barrel cortex. J Physiol 2002;545:521-535.

  49. Lauri SE, Bortolotto ZA, Nistico R, et al. A Role for Ca2+ Stores in Kainate Receptor-Dependent Synaptic Facilitation and LTP at Mossy Fiber Synapses in the Hippocampus. Neuron 2003;39:327-341.

  50. Smith AB, Cunnane TC. Ryanodine-sensitive calcium stores involved in neurotransmitter release from sympathetic nerve terminals of the guinea-pig. J Physiol 1996;497(Pt 3):657-664.

  51. Peng Y. Ryanodine-sensitive component of calcium transients evoked by nerve firing at presynaptic nerve terminals. J Neurosci J Soc Neurosci 1996;16:6703-6712.

  52. Shakiryanova D, Tully A, Hewes RS et al. Activity-dependent liberation of synaptic neuropeptide vesicles. Nat Neurosci 2005;8:173–178.

  53. Shakiryanova D, Klose MK, Zhou Y et al. Presynaptic ryanodine receptor- activated calmodulin kinase II increases vesicle mobility and potentiates neuropeptide release. J Neurosci J Soc Neurosci 2007;27:7799-7806.

  54. Shakiryanova D, Levitan ES. Prolonged presynaptic posttetanic cyclic GMP signaling in Drosophila motoneurons. Proc Natl Acad Sci U S A 2008;105:13610-13613.

  55. Trueta C, Sánchez-Armass S, Morales MA et al. Calcium-induced calcium release contributes to somatic secretion of serotonin in leech Retzius neurons. J Neurobiol 2004;61:309-316.

  56. Lattanzio FA Jr, Schlatterer RG, Nicar M et al. The effects of ryanodine on passive calcium fluxes across sarcoplasmic reticulum membranes. J Biol Chem 1987;262:2711-2718.

  57. McPherson PS, Kim YK, Valdivia H et al. The brain ryanodine receptor: a caffeine-sensitive calcium release channel. Neuron 1991;7:17-25.

  58. Meissner G. Ryanodine activation and inhibition of the Ca2+ release channel of sarcoplasmic reticulum. J Biol Chem 1986;261:6300-6306.

  59. Lambert RC, Dayanithi G, Moos FC et al. A rise in the intracellular Ca2+ concentration of isolated rat supraoptic cells in response to oxytocin. J Physiol 1994;478(Pt 2):275-287.

  60. Lessmann V, Gottmann K, Malcangio M. Neurotrophin secretion: current facts and future prospects. Prog Neurobiol 2003;69:341-374.

  61. Patel JC, Witkovsky P, Avshalumov MV et al. Mobilization of calcium from intracellular stores facilitates somatodendritic dopamine release. J Neurosci J Soc Neurosci 2009;29:6568-6579.

  62. Hua X, Malarkey EB, Sunjara V et al. C(a2+)-dependent glutamate release involves two classes of endoplasmic reticulum Ca(2+) stores in astrocytes. J Neurosci Res 2004;76:86-97.

  63. Llano I, Dreessen J, Kano M et al. Intradendritic release of calcium induced by glutamate in cerebellar Purkinje cells. Neuron 1991;7:577-583.

  64. Kano M, Garaschuk O, Verkhratsky A, et al. Ryanodine receptor-mediated intracellular calcium release in rat cerebellar Purkinje neurones. J Physiol 1995;487(Pt 1):1-16.

  65. Sun MK, Nelson TJ, Alkon DL. Functional switching of GABAergic synapses by ryanodine receptor activation. Proc Natl Acad Sci U S A 2000;97:12300-12305.

  66. Emptage N, Bliss TV, Fine A. Single synaptic events evoke NMDA receptor-mediated release of calcium from internal stores in hippocampal dendritic spines. Neuron 1999;22:115-124.

  67. Del Castillo, J, Katz B. Statistical nature of facilitation at a single nerve- muscle junction. Nature 1953;171:1016-1017.

  68. Wong MY, Shakiryanova D, Levitan ES. Presynaptic ryanodine receptor- CamKII signaling is required for activity-dependent capture of transiting vesicles. J Mol Neurosci MN 2009;37:146-150.




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