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2013, Número 3

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Revista del Hospital Psiquiátrico de La Habana 2013; 10 (3)


Bases genéticas de las principales hipótesis etiológicas en la esquizofrenia

Robaina JZ, Noa HIV

Idioma: Español
Referencias bibliográficas: 31
Paginas:
Archivo PDF: 72.82 Kb.


RESUMEN

Introducción: la esquizofrenia puede definirse como una enfermedad genética compleja, probablemente el resultado de la interacción de múltiples alelos de varios genes distintos con pequeños efectos.
Objetivo: Mostrar el estado del conocimiento acerca de los mecanismos moleculares involucrados en el origen y la progresión de esta condición.
Métodos: es una revisión temática, se realizó la búsqueda en PubMed/MEDLINE en publicaciones de los últimos 10 años, utilizándose solamente aquellas con texto completo e información novedosa sobre el tema.
Desarrollo: una exposición de los principales avances que en los últimos años han tenido lugar en la investigación biológica de las enfermedades psiquiátricas a través de la revisión de las bases genéticas en las que se apoyan las principales hipótesis etiológicas en la esquizofrenia.
Conclusiones: A pesar de los inmensos esfuerzos dedicados a la investigación de las causas de la esquizofrenia los mecanismos biológicos que subyacen en su fisiopatología aun no están bien esclarecidos.


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