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2013, Número 3

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Biotecnol Apl 2013; 30 (3)


La teranóstica y las imágenes moleculares: Nuevos conceptos y tecnologías para el desarrollo de fármacos

Cabal C, Darias D, González E, Musacchio A

Idioma: Ingles.
Referencias bibliográficas: 107
Paginas: 172-177
Archivo PDF: 196.58 Kb.


RESUMEN

En este artículo se discuten algunas de las bases, los retos y el uso de las imágenes moleculares y la teranóstica en un futuro cercano. Las imágenes moleculares, cuya evolución en los últimos años ha sido sorprendente, se han convertido en verdaderas herramientas para disminuir los costos y acelerar todas las etapas de los procesos de descubrimiento y desarrollo de nuevos fármacos. La integración de las actuales plataformas de la teranóstica con las tecnologías de imágenes ha abierto oportunidades novedosas y revolucionarias en la medicina y las industrias biotecnológicas y farmacéuticas. La estrategia de unir agentes diagnósticos y terapéuticos en una nanoplataforma ofrece la posibilidad de diagnosticar, tratar y monitorear la respuesta terapéutica in vivo a nivel molecular. Esto permite mejorar simultáneamente la evaluación, la optimización, el control y la eficacia de la distribución y liberación de los medicamentos. Estas formulaciones teranósticas también han incrementado la sensibilidad de las imágenes moleculares de resonancia magnética hasta algunos picomoles. Como conclusión se afirma que la conjugación de complejos paramagnéticos con macromoléculas y nanoestructuras naturales flexibles es la vía más importante y rápida para obtener nuevas formulaciones teranósticas. Para optimizar los ensayos preclínicos y clínicos es necesario que desde el inicio se diseñen teniendo en cuenta las posibilidades de las tecnologías de imágenes. Los problemas complejos asociados con la medicina personalizada, la terapia combinada y la sincronización entre las acciones diagnósticas y terapéuticas encuentran una excelente solución en el campo de la teranóstica.


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