2013, Número 6
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salud publica mex 2013; 55 (6)
El medio ambiente interno* Una exploración del papel de la microbioma intestinal en la salud y la enfermedad
Idioma: Español
Referencias bibliográficas: 38
Paginas: 672-681
Archivo PDF: 825.62 Kb.
FRAGMENTO
El genoma humano codifica
aproximadamente 23 000 genes;
sin embargo, algunos expertos
han sugerido que la información total
codificada por el genoma humano
no basta por sí sola para realizar
todas las funciones biológicas del
cuerpo.
REFERENCIAS (EN ESTE ARTÍCULO)
DOE. About the Human Genome Project. How Many Genes are in the Human Genome? [página web]. Washington, DC: Proyecto del Genoma Humano, Oficina de Ciencias, Departamento de Energía de Estados Unidos (modificada el 23 de julio de 2013). Disponible en: http://goo.gl/HSfbE3 [consultada el 13 de agosto de 2013].
Lee YK, Mazmanian SK. Has the microbiota played a critical role in the evolution of the adaptive immune system? Science 330(612):1768–1773 (2010); http://dx.doi. org/10.1126/science.1195568.
Zhu B, et al. Human gut microbiome: the second genome of human body. Protein Cell 1(8):718–725 (2010); http://dx.doi.org/10.1007/ s13238-010-0093-z.
Sokol H, et al. Specificities of the fecal microbiota in inflammatory bowel disease. Inflamm Bowel Dis 12(2):106–111 (2006); http:// dx.doi.org/10.1097/01.MIB.0000200323.38139.c6.
Round JL, Mazmanian SK. The gut microbiota shapes intestinal immune responses during health and disease. Nat Rev Immunol 9(5):313–323 (2009); http://dx.doi.org/10.1038/nri2515.
Bested AC, et al. Intestinal microbiota, probiotics and mental health: from Metchnikoff to modern advances: part III—convergence toward clinical trials. Gut Pathog 5(1):4 (2013); http://dx.doi.org/10.1186/1757-4749-5-4.
Podolsky SH. Metchnikoff and the microbiome. Lancet 380(9856):1810–1811 (2012); http:// dx.doi.org/10.1016/S0140-6736(12)62018-2.
Lee YK, et al. Proinflammatory T-cell responses to gut microbiota promote experimental autoimmune encephalomyelitis. ProcNatlAcadSci USA 108(supl 1):4615–4622 (2011); http://dx.doi. org/10.1073/pnas.1000082107.
Blainey PC, et al. Quantitative analysis of the human airway microbial ecology reveals a pervasive signature for cystic fibrosis. SciTransl Med 4(153):153ra130 (2012); http://dx.doi. org/10.1126/scitranslmed.3004458.
DiGiulio DB, et al. Microbial prevalence, diversity and abundance in amniotic fluid during preterm labor: a molecular and culture-based investigation. PLoS ONE 3(8):e3056 (2006); http://dx.doi.org/10.1371/journal.pone.0003056.
Cabrera-Rubio R, et al. The human milk microbiome changes over lactation and is shaped by maternal weight and mode of delivery. Am J ClinNutr 96(3):544–551 (2012); http://dx.doi. org/10.3945/ajcn.112.037382.
Fetissov SO, Dechelotte P. The new link between gut–brain axis and neuropsychiatric disorders.CurrOpinNutrMetab Care 14(5):477–482 (2011); http://dx.doi.org/10.1097/ MCO.0b013e32834936e7.
Kranich J, et al. Commensal flora and the regulation of inflammatory and autoimmune responses. SeminImmunol 23(2):139–145 (2011); http://dx.doi.org/10.1016/j.smim.2011.01.011.
Tringe SG, Rubin EM. Metagenomics: DNA sequencing of environmental samples. Nat Rev Genet 6(11):805–814 (2005); http://dx.doi. org/10.1038/nrg1709.
Markle JGM, et al. Sex differences in the gut microbiome drive hormone-dependent regulation of autoimmunity. Science 339(6123):1084–1088 (2013); http://dx.doi. org/10.1126/science.1233521.
Sellitto M, et al. Proof of concept of microbiome–metabolome analysis and delayed gluten exposure on celiac disease autoimmunity in genetically at-risk infants. PLoS ONE 7(3):e33387 (2012); http://dx.doi.org/10.1371/ journal.pone.0033387.
Selmi C, Gershwin ME. The role of environmental factors in primary biliary cirrhosis. Trends Immunol 30(8):415–420 (2009); http:// dx.doi.org/10.1016/j.it.2009.05.006.
Dominguez-Bello MG, et al. Delivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats in newborns. ProcNatlAcadSci USA 107(26):11971– 11975 (2010); http://dx.doi.org/10.1073/ pnas.1002601107.
Huurre A, et al. Mode of delivery—effects on gut microbiota and humoral immunity. Neonatology 93(4):236–240 (2008); http://dx.doi. org/10.1159/000111102.
Committee on Metagenomics, National Research Council. The New Science of Metagenomics: Revealing the Secrets of Our Microbial Planet. Washington, DC: The National Academies Press (2007). Disponible en: http:// www.nap.edu/catalog.php?record_id=11902 [consultado el 13 de agosto de 2013].
Turnbaugh PJ, et al. The Human Microbiome Project. Nature 449(7164):804–810 (2007); http://dx.doi.org/10.1038/nature06244.
Maurice CF, et al. Xenobiotics shape the physiology and gene expression of the active human gut microbiome. Cell 152(1):39–50 (2013); http://dx.doi.org/10.1016/j. cell.2012.10.052.
Jakobsson HE, et al. Short-term antibiotic treatment has differing long-term impacts on the human throat and gut microbiome. PLoS ONE 5(3):e9836 (2010); http://dx.doi.org/10.1371/ journal.pone.0009836.
Choi JJ, et al. Exercise attenuates PCB-induced changes in the mouse gut microbiome. Environ Health Perspect 121(6):725–730 (2013); http:// dx.doi.org/10.1289/ehp.1306534.
Sommer MO, Dantas G. Antibiotics and the resistant microbiome. CurrOpinMicrobiol 14(5):556–563 (2011); http://dx.doi.org/10.1016/j. mib.2011.07.005.
NIEHS. National Advisory Environmental Health Sciences Council, 15–16 February 2012. Concept Clearance.Microbiome/Environment Interactions. Research Triangle Park, NC: Departamento de Patobiología Celular, de Órganos y de Sistemas; División de Investigación y Capacitación Extramuros,Instituto Nacional de Salud ambiental de Estados Unidos (2012). Disponible en: http://goo.gl/wTrpsI [consultada el 13 de agosto de 2013].
Kunde S, et al. Safety, tolerability, and clinical response after fecal transplantation in children and young adults with ulcerative colitis. J PediatrGastroenterolNutr 56(6):597– 601 (2013); http://dx.doi.org/10.1097/ MPG.0b013e318292fa0d.
Zhang T, et al. RNA viral community in human feces: prevalence of plant pathogenic viruses. PLoSBiol 4(1):e3 (2006); http://dx.doi.org/ doi:10.1371/journal.pbio.0040003.
Liu R, et al. Humans have antibodies against a plant virus: evidence from tobacco mosaic virus. PLoS ONE 8(4):e60621 (2013); http://dx.doi. org/10.1371/journal.pone.0060621.
Herper M. How a failed Alzheimer’s drug illustrates the drug industry’s gambling problem. Forbes, sección Negocios (Business), edición en línea (8 de agosto de 2012). Disponible en: http:// goo.gl/okxbv9 [consultada el 13 de agosto de 2013].
Friedland RP, et al. Antibodies to potato virus Y bind the amyloid peptide: immunohistochemical and NMR studies. J BiolChem 283(33):22550–22556 (2008); http:// dx.doi.org/10.1074/jbc.M802088200.
Xu J, et al. A genomic view of the human–B acteroidesthetaiotaomicronsymbiosis. Science 299(5615):2074–2076 (2003); http://dx.doi. org/10.1126/science.1080029.
Rupnik M, et al. Clostridium difficileinfection: new developments in epidemiology and pathogenesis. NatRevMicrobiol 7:526–536 (2009); http://dx.doi.org/10.1038/nrmicro2164.
O’Hara AM, Shanahan F. The gut flora as a forgotten organ. EMBO Rep 7(7):688–693 (2006); http://dx.doi.org/10.1038/sj.embor.7400731.
Monick M, et al. Effects of Eyjafjallajökull volcanic ash on innate immune system responses and bacterial growth in vitro. Environ Health Perspect 121(6):691–698 (2013); http://dx.doi. org/10.1289/ehp.1206004.
Simkin T, Siebert L (2002-). Global Volcanism FAQs.Smithsonian Institution, Global Volcanism Program Digital Information Series, GVP-5. Disponible en: http://goo.gl/8evCT [consultada el 2 de mayo de 2013].
USGS. Ash Properties & Dispersal by Wind [página web]. Reston, VA: Programa de Riesgos Volcánicos, Servicio de Evaluación Geológica de Estados Unidos (actualizada el 3 de febrero de 2009). Disponible en: http://volcanoes.usgs.gov/ ash/properties.html [consultada el 2 de mayo de 2013].
Pseudomonas aeruginosa [página web]. Gambier, OH: Wiki de Microbios, Departamento de Biología de Kenyon College (actualizada el 4 de enero de 2012). Disponible en: http://goo.gl/hyBHT [consultada el 2 de mayo de 2013].