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2005, Número 3

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Rev Inst Nal Enf Resp Mex 2005; 18 (3)


Evaluación del posible papel de la osteopontina como marcador biológico en la fibrosis pulmonar idiopática

García AC, Gaxiola M, Cisneros J, Pardo A, Selman M

Idioma: Español
Referencias bibliográficas: 39
Paginas: 187-194
Archivo PDF: 74.89 Kb.


RESUMEN

Introducción: La fibrosis pulmonar idiopática (FPI) es una neumopatía crónica de difícil diagnóstico que puede confundirse con otras enfermedades pulmonares intersticiales difusas (EPID), por lo que es importante buscar nuevos métodos auxiliares para su diagnóstico. La osteopontina (OPN) es una glicoproteína multifuncional con efecto estimulante sobre los fibroblastos y la síntesis de matriz extracelular. Dado su posible papel profibrosante, consideramos de interés evaluar su concentración en el lavado bronquioalveolar (LBA) de pacientes con FPI y compararla con otras EPID. Material y métodos: La OPN se cuantificó por ELISA en 25 pacientes con FPI, 10 con neumonía intersticial no específica (NINE), 16 con neumonitis por hipersensibilidad (NH) y 10 controles sanos. Resultados: La concentración de OPN en pacientes con FPI fue significativamente mayor que en pacientes con NH y sanos (p ‹ 0.0001) así como en pacientes con NINE (p ‹ 0.05). Esta prueba mostró una sensibilidad de 80% y especificidad de 75% para el diagnóstico de FPI cuando el logaritmo de la concentración de OPN es de 3 2.0. No hubo correlación entre los niveles de OPN con las pruebas de función pulmonar. Es interesante observar una asociación significativa entre los niveles de OPN y la presencia de hipocratismo digital (RM: 6.69; IC 1.25-10.76; p ‹ 0.05). Conclusiones: La OPN se encuentra elevada en el LBA de pacientes con FPI por lo que podría considerarse como una prueba auxiliar en el diagnóstico diferencial de las EPID. Adicionalmente, nuestros hallazgos sugieren que la OPN puede estar implicada en la patogénesis del hipocratismo digital.


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