Durán LM, Gaitán IR, Olivero VJT

Idioma: Español
Referencias bibliográficas: 65
Paginas: 416-430
Archivo PDF: 247.72 Kb.

RESUMEN

Introducción: las quinonas son moléculas biológicas ampliamente distribuidas en la naturaleza. Recientemente el grupo de investigación de productos naturales, de la Universidad de Cartagena; obtuvo por extracción de plantas del género tabebuia y por síntesis química un número importante de estos compuestos. Sin embargo, con el fin de seguir profundizando en los estudios de sus actividades y su relación con el tipo de estructura lineal o angular se realizó una revisión en varias bases de datos.
Objetivo: buscar información que permitiera conocer si los compuestos obtenidos se encontraban reportados; así como también la actividad biológica y los bioensayos realizados a estas moléculas in vivo, in vitro e in silico.
Métodos: esta investigación fue desarrollada con el uso de un diseño que aplicó la edición de moléculas, mediante la interfaz gráfica de servidores (PUBCHEM CHEMIDPLUS ADVANCE, CHEBI) y una búsqueda de datos complementarios en la base de datos PUBMED. Los datos de la actividad biológica más relevantes fueron relacionados con la estructura química de los compuestos sintetizados y de los análogos suministrados por PUBMED.
Resultados: de los compuestos hallados en las bases de datos, 24 presentaron código en la base de datos PUBCHEM, 12 mostraron reportes de actividad biológica en las bases de datos, y se encontró que el mayor número de bioensayos fue reportado con furanonaftoquinonas, seguido por naftoquinonas.
Conclusiones: la actividad citotóxica y anticancerígena en diferentes líneas celulares, representa el mayor número de bioensayos realizados a estos compuestos.

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