Monroy-Muñoz IE, Pérez-Hernández N, Vargas-Alarcón G, Ortiz-San Juan G, Buendía-Hernández A, Calderón-Colmenero J, Ramírez-Marroquín S, Cervantes-Salazar JL, Curi-Curi P, Martínez-Rodríguez N, Rodríguez PJM

Idioma: Español
Referencias bibliográficas: 53
Paginas: 212-219
Archivo PDF: 678.27 Kb.

RESUMEN

El desarrollo embrionario del corazón consiste en una serie de interacciones morfogenéticas complejas y específicas, que requieren del correcto funcionamiento de cada uno de los factores implicados en la cardiogénesis. Las cardiopatías congénitas (CC) son enfermedades complejas y multifactoriales, en las que el factor ambiental y el genético son de gran relevancia. No existe una correlación exacta entre los mecanismos moleculares y los defectos morfológicos de las CC, ya que en la mayoría de los casos la formación adecuada de una estructura anatómica implica el correcto funcionamiento de varias vías, las cuales pueden involucrar el producto de distintos genes. En este artículo se resumen los diferentes factores genéticos implicados en el desarrollo normal del corazón, así como las alteraciones más frecuentes que se han asociado con el desarrollo de las cardiopatías congénitas.

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