Balas-Nakash M, Perichart-Perera O, Benítez-Arciniega A, Tolentino-Dolores M, Mier-Cabrera J, Vadillo-Ortega F

Idioma: Español
Referencias bibliográficas: 45
Paginas: 196-203
Archivo PDF: 114.91 Kb.

RESUMEN

Objetivo: Evaluar las diferencias en marcadores de inflamación y riesgo cardiovascular en escolares con y sin adiposidad excesiva, así como la asociación entre la inflamación y los factores de riesgo cardiovascular. Material y métodos: Estudio transversal (n = 285 niños; edad: 8-12 años). Se midió la adiposidad (índice de masa corporal [IMC], grasa corporal y circunferencia de cintura [CCin]), inflamación (proteína C reactiva [PCR], interleucina 1β [IL-1β], interleucina 6 [IL-6] y factor de necrosis tumoral α [TNF-α]) y riesgo cardiovascular. Se realizó estadística descriptiva, diferencias de medias y modelos de regresión múltiple. Resultados: Los escolares con obesidad presentaron mayores concentraciones de PCR e IL-1β, y aquellos con obesidad abdominal mayores concentraciones de PCR. Las concentraciones de PCR e IL-1β se correlacionaron con los tres indicadores de adiposidad. Las concentraciones de IL-6 se asociaron con las concentraciones de triacilglicéridos (TAG) y las de IL-1β con las de colesterol unido a lipoproteínas de alta densidad (C-HDL), ajustado por IMC. Discusión: En este grupo de escolares mexicanos, la obesidad aumentó el riesgo cardiovascular y algunos marcadores de inflamación. Las concentraciones de IL-6 e IL-1β parecen ser factores que participan en la alteración de lípidos, independientemente de la presencia de obesidad. Se requieren más estudios que exploren el papel de la inflamación subclínica en el desarrollo de alteraciones cardiovasculares ya descritas en niños mexicanos con obesidad.

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