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Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán

2012, Número 6

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Rev Invest Clin 2012; 64 (6)


Papel de los canales de sodio activados por voltaje en la capacidad metastásica de las células cancerosas

Hernández-Plata E

Idioma: Español
Referencias bibliográficas: 60
Paginas: 567-575
Archivo PDF: 291.87 Kb.


RESUMEN

La expresión funcional de canales de sodio dependientes de voltaje (NaV) en células cancerosas está asociada al incremento de la capacidad metastásica. La actividad de los canales NaV modula distintos procesos celulares relacionados con el desarrollo del fenotipo maligno, tales como la adhesión, galvanotaxis, movilidad e invasividad. Dentro de la gran diversidad de fenotipos cancerosos la expresión de canales NaV es común dentro de las células altamente metastásicas; sin embargo, el tipo particular del canal expresado parece depender del tejido en el que se genera el tumor primario. El propósito de este artículo es revisar la literatura sobre los canales NaV expresados en distintos tipos de cáncer, los procesos celulares en los que participan y los mecanismos moleculares por los cuales promueven metástasis.


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