medigraphic.com
Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán

2012, Número 1

<< Anterior Siguiente >>

Rev Invest Clin 2012; 64 (1)


Papel de la cirugía en pacientes con cáncer de mama metastásico

Medina-Franco H, Suárez-Bobadilla YL

Idioma: Español
Referencias bibliográficas: 58
Paginas: 81-88
Archivo PDF: 141.99 Kb.


RESUMEN

El cáncer de mama es la neoplasia maligna con mayor incidencia en mujeres mexicanas, en un número significativo de casos se presenta en etapas avanzadas. Las pacientes con enfermedad metastásica tienen opciones terapéuticas limitadas, la piedra angular del tratamiento continúa siendo la quimioterapia sistémica. Tradicionalmente, el papel de la cirugía en este contexto se ha limitado estrictamente a la paliación. La mejoría en la eficacia de los agentes quimioterapéuticos, en conjunto con hormonoterapia y la terapia blanco molecular, han incrementado la sobrevida de estas pacientes y expandido las indicaciones quirúrgicas más allá de la simple paliación. Algunos reportes institucionales sugieren mejoría en la sobrevida de las pacientes cuando se logra la resección de enfermedad metastásica limitada. Asimismo, algunos informes recientes sugieren mejoría del pronóstico cuando se realiza resección del tumor primario en presencia de metástasis. Se realizó una revisión sistemática de la literatura con el objetivo de evaluar el papel de la cirugía en pacientes con cáncer de mama metastásico y establecer su lugar en el contexto de manejo multidisciplinario para mejorar el pronóstico de este grupo numeroso y creciente de pacientes.


REFERENCIAS (EN ESTE ARTÍCULO)

  1. Jemal A, Siegel R, Ward E, Murray T, Xu J, Thun MJ. Cancer statistics, 2007. CA Cancer J Clin 2007; 57: 43-66.

  2. Available from: http://seer.cancer.gov/statfacts/html/ breast.html#survival

  3. Pockaj BA, Wasif N, Dueck AC, Wigle DA, Boughey JC, Degnim AC, et al. Metastasectomy and surgical resection of the primary tumor in patients with stage IV breast cancer. Time for a second look? Ann Surg Oncol 2010: 17: 2419-26.

  4. Ruiterkamp J, Voogd AC, Bosscha K, Tjan-Heijnen VC, Ernst MF. Impact of breast surgery on survival in patients with distant metastases at initial presentation: a systematic review of the literature. Breast Cancer Res Treat 2010; 1201: 9-16.

  5. Wyld L, Gutteridge E, Pinder SE, James JJ, Chan SY, Cheung KL, et al. Prognostic factors for patients with hepatic metastases from breast cancer. Br J Cancer 2003; 89: 284-90.

  6. Raab R, Nussbaum KT, Behrend M, Weimann A. Liver metastases of breast cancer: results of liver resection. Anticancer Res 1998; 18: 2231-3.

  7. Seifert JK, Weigel TF, Gonner U, Bottger TC, Junginger T. Liver resection for breast cancer metastases. Hepatogastroenterology 1999; 46: 2935-40.

  8. Selzner M, Morse MA, Vredenburgh JJ, Meyers WC, Clavien PA. Liver metastases from breast cancer: long-term survival after curative resection. Surgery 2000; 127: 383-9.

  9. Yoshimoto M, Tada T, Saito M, Takahashi K, Uchida Y, Kasumi F. Surgical treatment of hepatic metastases from breast cancer. Breast Cancer Res Treat 2000; 59: 177-84.

  10. Pocard M, Pouillart P, Asselain B, Falcou MC, Salmon RJ. Hepatic resection for breast cancer metastases: results and prognosis (65 cases). Ann Chir 2001; 126: 413-20.

  11. Carlini M, Lonardo MT, Carboni F, Petric M, Vitucci C, Santoro R, et al. Liver metastases from breast cancer: results of surgical resection. Hepatogastroenterology 2002; 49: 1597-601.

  12. Elias D, Maisonnette F, Druet-Cabanac M, Ouellet JF, Guinebretiere JM, Spielmann M, et al. An attempt to clarify indications for hepatectomy for liver metastases from breast cancer. Am J Surg 2003; 185: 158-64.

  13. Vlastos G, Smith DL, Singletary SE, Mirza NQ, Tuttle TM, Popat RJ, et al. Long-term survival after an aggressive surgical approach in patients with breast cancer hepatic metastases. Ann Surg Oncol 2004; 11: 869-74.

  14. Sakamoto Y, Yamamoto J, Yoshimoto M, Kasumi F, Kosuge T, Kokudo N, et al. Hepatic resection for metastatic breast cancer: prognostic analysis of 34 patients. World J Surg 2005; 29: 524-7.

  15. d’Annibale M, Piovanello P, Cerasoli V, Campioni N. Liver metastases from breast cancer: the role of surgical treatment. Hepatogastroenterology 2005; 52: 1858-62.

  16. Ercolani G, Grazi GL, Ravaioli M, Ramacciato G, Cescon M, Varotti G, et al. The role of liver resections for noncolorectal, nonneuroendocrine metastases: experience with 142 observed cases. Ann Surg Oncol 2005; 12: 459-66.

  17. Adam R, Aloia T, Krissat J, Bralet MP, Paule B, Giacchetti S, et al. Is liver resection justified for patients with hepatic metastases from breast cancer? Ann Surg 2006; 244: 897-907.

  18. Furka A, Halasz L, Szentkereszty Z, Posan J, Andras C, Sapy P. Surgical treatment of liver metastases from breast cancer. Hepatogastroenterology 2008; 55: 1416-8.

  19. Caralt M, Bilbao I, Cortes J, Escartin A, Lazaro JL, Dopazo C, et al. Hepatic resection for liver metastases as part of the ‘‘oncosurgical’’ treatment of metastatic breast cancer. Ann Surg Oncol 2008; 15: 2804-10.

  20. Lubrano J, Roman H, Tarrab S, Resch B, Marpeau L, Scotte M. Liver resection for breast cancer metastasis: does it improve survival? Surg Today 2008; 38: 293-9.

  21. Thelen A, Benckert C, Jonas S, Lopez-Hanninen E, Sehouli J, Neumann U, et al. Liver resection for metastases from breast cancer. J Surg Oncol 2008; 97: 25-9.

  22. Hoffmann K, Franz C, Hinz U, Herfarth C, Eichbaum M, Büchler MW, Schemmer P. Liver resection for multimodal treatment of breast cancer metastases: identification of prognostic factors. Ann Surg Oncol 2010; 17: 1546-54.

  23. Simmonds PC, Primrose JN, Colquitt JL, Garden OJ, Poston GJ, Rees M. Surgical resection of hepatic metastases from colorectal cancer: a systematic review of published studies. Br J Cancer 2006; 94: 982-99.

  24. Lanza LA, Natarajan G, Roth JA, Putnam JB Jr. Long-term survival after resection of pulmonary metastases from carcinoma of the breast. Ann Thorac Surg 1992; 54: 244-7.

  25. Friedel G, Linder A, Toomes H. The significance of prognostic factors for the resection of pulmonary metastases of breast cancer. Thorac Cardiovasc Surg 1994; 42: 71-5.

  26. McDonald ML, Deschamps C, Ilstrup DM, Allen MS, Trastek VF, Pairolero PC. Pulmonary resection for metastatic breast cancer. Ann Thorac Surg 1994; 58: 1599-602.

  27. Murabito M, Salat A, Mueller MR. Complete resection of isolated lung metastasis from breast carcinoma results in a strong increase in survival. Minerva Chir 2000; 55: 121-7.

  28. Friedel G, Pastorino U, Ginsberg RJ, Goldstraw P, Johnston M, Pass H, et al. Results of lung metastasectomy from breast cancer: prognostic criteria on the basis of 467 cases of the International Registry of Lung Metastases. Eur J Cardiothorac Surg 2002; 22: 335-44.

  29. Ludwig C, Stoelben E, Hasse J. Disease-free survival after resection of lung metastases in patients with breast cancer. Eur J Surg Oncol 2003; 29: 532–5.

  30. Planchard D, Soria JC, Michiels S, Grunenwald D, Validire P, Caliandro R, et al. Uncertain benefit from surgery in patients with lung metastases from breast carcinoma. Cancer 2004; 100: 28-35.

  31. Welter S, Jacobs J, Krbek T, Totsch M, Stamatis G. Pulmonary metastases of breast cancer: when is resection indicated? Eur J Cardiothorac Surg 2008; 34: 1228-34.

  32. Yoshimoto M, Tada K, Nishimura S, Makita M, Iwase T, Kasumi F, et al. Favorable long-term results after surgical removal of lung metastases of breast cancer. Breast Cancer Res Treat 2008; 110: 485-91.

  33. Chen F, Fujinaga T, Sato K, Sonobe M, Shoji T, Sakai H, et al. Clinical features of surgical resection for pulmonary metastasis from breast cancer. Eur J Surg Oncol 2009; 35: 393-7.

  34. Swenerton KD, Legha SS, Smith T, Hortobagyi GN, Gehan EA, Yap HY, et al. Prognostic factors in metastatic breast cancer treated with combination chemotherapy. Cancer Res 1979; 39: 1552-62.

  35. Patanaphan V, Salazar OM, Risco R. Breast cancer: metastatic patterns and their prognosis. South Med J 1988; 81: 1109-12.

  36. Staren ED, Salerno C, Rongione A, Witt TR, Faber LP. Pulmonary resection for metastatic breast cancer. Arch Surg 1992; 127: 1282-4.

  37. Pieper DR, Hess KR, Sawaya RE. Role of surgery in the treatment of brain metastases in patients with breast cancer. Ann Surg Oncol 1997; 4: 481-90.

  38. Wronski M, Arbit E, McCormick B. Surgical treatment of 70 patients with brain metastases from breast carcinoma. Cancer 1997; 80: 1746-54.

  39. Fokstuen T, Wilking N, Rutqvist LE, Wolke J, Liedberg A, Signomklao T, et al. Radiation therapy in the management of brain metastases from breast cancer. Breast Cancer Res Treat 2000; 62: 211-6.

  40. Durr HR, Muller PE, Lenz T, Baur A, Jansson V, Refior HJ, et al. Surgical treatment of bone metastases in patients with breast cancer. Clin Orthop Relat Res 2002; 396: 191-6.

  41. van Geel AN, Wouters MW, van der Pol C, Schmitz PI, Lans T. Chest wall resection for internal mammary lymph node metastases of breast cancer. Breast 2009; 18: 94–9.

  42. Incarbone M, Nava M, Lequaglie C, Ravasi G, Pastorino U. Sternal resection for primary or secondary tumors. J Thorac Cardiovasc Surg 1997; 114: 93-9.

  43. Ayhan A, Guvenal T, Salman MC, Ozyuncu O, Sakinci M, Basaran M. The role of cytoreductive surgery in nongenital cancers metastatic to the ovaries. Gynecol Oncol 2005; 98: 235-41.

  44. McLemore EC, Pockaj BA, Reynolds C, Gray RJ, Hernandez JL, Grant CS, et al. Breast cancer: presentation and intervention in women with gastrointestinal metastasis and carcinomatosis. Ann Surg Oncol 2005; 12: 886-94.

  45. Castillo OA, Vitagliano G, Kerkebe M, Parma P, Pinto I, Diaz M. Laparoscopic adrenalectomy for suspected metastasis of adrenal glands: our experience. Urology 2007; 69: 637-41.

  46. Zecchin D, Bardelli A. Tracking the genomic evolution of breast cancer metastasis. Breast Cancer Res 2010; 12: 302.

  47. Vecchi M, Confalonieri S, Nuciforo P, Vigano MA, Capra M, Branchi M, et al. Breast cancer metastases are molecularly distinct from their primary tumors. Oncogene 2008; 27: 2148-58.

  48. Carlsson J, Nordgien H, Sjöström J, Wester K, Villman K, Bengtsson NO, et al. HER-2 expression in breast cancer primary tumors and corresponding metastases. Original data and literature review. Br J Cancer 2004; 90: 2344-8.

  49. Khan SA, Stewart AK, Morrow M. Does aggressive local therapy improve survival in metastatic breast cancer? Surgery 2002; 132: 20-6.

  50. Babiera GV, Rao R, Feng L, Meric-Bernstam F, Kuerer HM, Singeltary SE, et al. Effect of primary tumor extirpation in breast cancer patients who present with stage IV disease and an intact primary tumor. Ann Surg Oncol 2006; 13: 776-82.

  51. Rapiti E, Verkooijen HM, Vlastos G, Fioretta G, Neyroud-Caspar I, Sappino AP, et al. Complete excision of primary breast tumor improves survival of patients with metastatic cancer at diagnosis. J Clin Oncol 2006; 24: 2743-9.

  52. Fields RC, Jeffe DB, Trinkaus K, Zhang Q, Arthur C, Aft R, et al. Surgical resection of the primary tumor is associated with increased long-term survival in patients with stage IV breast cancer after controlling for site of metastasis. Ann Surg Oncol 2007; 14: 3345-51.

  53. Gnerlich J, Jeffe DB, Deshpande AD, Beers C, Zander C, Margenthaler JA. Surgical removal of the primary tumor increases overall survival in patients with metastatic breast cancer: analysis of the 1988-2003 SEER data. Ann Surg Oncol 2007; 14: 2187-94.

  54. Blanchard DK, Shetty PB, Hilsenbeck SG, Elledge RM. Association of surgery with improved survival in stage IV breast cancer patients. Ann Surg 2008; 247: 732-8.

  55. Ruiterkamp J, Ernst MF, van de Poll-Franse LV, Bosscha K, Tjan-Heijnen VC, Voogd AC. Surgical resection of the primary tumor is associated with improved survival in patients with distant metastatic breast cancer at diagnosis. Eur J Surg Oncol 2009; 35: 1146-51.

  56. Cady B, Nathan NR, Michaelson JS, Golshan M, Smith BL. Matched air analysis of stage IV breast cancer with or without resection of primary breast site. Ann Surg Oncol 2008; 15: 3384-95.

  57. Holt A, Nelson R, Kruper L. Survival benefit of surgery in stage IV breast cancer patients? Ann Surg Oncol 2010; 17(S1): S11-Abst 17.

  58. Fields RC, Margenthaler JA. Surgical resection of the primary tumor in stage IV breast cancer patients: is a randomized, controlled trial imperative or too costly? J Surg Oncol 2009; 99: 85-6.




2020     |     www.medigraphic.com