García-González A, Lotz M, Ochoa JL

Idioma: Ingles.
Referencias bibliográficas: 30
Paginas: 212-220
Archivo PDF: 127.26 Kb.

RESUMEN

Introducción. La artritis reumatoide es una enfermedad inflamatoria de etiología autoinmune en la cual se ha postulado la participación de radicales libres en su génesis y perpetuación. Objetivo: Evaluar el efecto anti-inflamatorio de la Cu,Zn superóxido dismutasa obtenida de dos diferentes fuentes, eritrocitos de bovino y la levadura marina Debaryomyces hansenii en el modelo de artritis inducida por colágena tipo II en ratas. Material y métodos. La artritis se indujo mediante la inyección (día 0) de colágena porcina tipo II en el dorso de ratas Dark Augui. Se evaluaron frecuentemente la incidencia y la intensidad artritis (clínicamente), el peso, la histología y la presencia de anticuerpos anti-colágena (al final del experimento el día 28). Se estudiaron dos dosis de cada una de las enzimas: 100 y 1,000 U/kg, administradas diariamente por vía intraperitoneal. Resultados. La enzima de ambas fuentes disminuyó la incidencia y la intensidad de la artritis, exceptuando la dosis menor de eritrocitos de bovino. Se presentó un adecuado incremento en el peso. No hubo diferencia en la histología. Sólo el grupo que recibió la dosis mayor de la enzima de D. hasenii, disminuyó la producción de anticuerpos. Conclusiones. La enzima superóxido dismutasa tiene actividad anti-inflamatoria en este modelo animal. La dosis mayor de la enzima de D. hansenii tuvo mejor efecto.

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