Bautista CJ, Zambrano E

Idioma: Español
Referencias bibliográficas: 52
Paginas: 267-275
Archivo PDF: 179.28 Kb.

RESUMEN

Durante la gestación, la madre debe proporcionar al feto los nutrimentos necesarios para su adecuada diferenciación, maduración y crecimiento de órganos y sistemas. Durante este periodo, la madre adapta su metabolismo para solventar la continua demanda de sustratos que deben ser transferidos al feto a través de la placenta. Los ácidos grasos esenciales no pueden ser sintetizados por el humano, por tanto deben ser consumidos como parte de la dieta. Sus derivados, los ácidos grasos poli-insaturados de cadena larga (AGPIs-CL) provenientes de la biosíntesis en el hígado materno durante la gestación y la lactancia, son compuestos que van a formar parte de las membranas celulares del cerebro, retina, hígado, corazón del feto y del neonato, permitiendo así el buen funcionamiento, activación y regulación de las funciones celulares. Por tanto, el adecuado estado nutricio de la madre durante la gestación y la lactancia, es necesario para permitir el adecuado desarrollo del producto. Este artículo tiene como objetivo revisar algunos aspectos de los mecanismos de adaptación del metabolismo de lípidos maternos, principalmente de los AGPIs-CL que compensan el gasto energético y permiten el desarrollo adecuado del producto.

REFERENCIAS (EN ESTE ARTÍCULO)

1. Nien JK, Mazaki-Tovi S, Romero R, Kusanovic JP, Erez O, Gotsch F, Pineles BL, et al. Resistin: a hormone which induces insulin resistance is increased in normal pregnancy. J Perinat Med 2007; 35: 513-21.

2. Osol G, Mandala M. Maternal uterine vascular remodeling during pregnancy. Physiology (Bethesda) 2009; 24: 58-71.

3. Guan J, Mao C, Feng X, Zhang H, Xu F, Geng C, et al. Fetal development of regulatory mechanisms for body fluid homeostasis. Braz J Med Biol Res 2008; 41: 446-54.

4. Do Carmo S, Forest JC, Giguere Y, Masse A, Lafond J, Rassart E. Modulation of Apolipoprotein D levels in human pregnancy and association with gestational weight gain. Reprod Biol Endocrinol 2009; 7: 92.

5. Cetin I, Antonazzo P. The role of the placenta in intrauterine growth restriction (IUGR). Z Geburtshilfe Neonatol 2009; 213: 84-8.

6. Kallen CB. Steroid hormone synthesis in pregnancy. Obstet Gynecol Clin North Am 2004; 31: 795-816.

7. Hay WWJr. Placental-fetal glucose exchange and fetal glucose metabolism. Trans Am Clin Climatol Assoc 2006; 117: 321-39; discussion 39-40.

8. Rodriguez-Cruz M, Tovar AR, Palacios-Gonzalez B, Del Prado M, Torres N. Synthesis of long-chain polyunsaturated fatty acids in lactating mammary gland: role of Delta5 and Delta6 desaturases, SREBP-1, PPARalpha, and PGC-1. J Lipid Res 2006; 47: 553-60.

9. Campioni M, Toffolo GM, Basu R, Rizza RA, Cobelli C. Minimal Model Assessment of Hepatic Insulin Extraction during an Oral Test from Standard Insulin Kinetic Parameters. Am J Physiol Endocrinol Metab 2009;

10. Garcia-Guerra A, Neufeld LM, Hernandez-Cordero S, Rivera J, Martorell R, Ramakrishnan U. Prenatal multiple micronutrient supplementation impact on biochemical indicators during pregnancy and postpartum. Salud Pública Méx 2009; 51: 327-35.

11. Mangravite LM, Dawson K, Davis RR, Gregg JP, Krauss RM. Fatty acid desaturase regulation in adipose tissue by dietary composition is independent of weight loss and is correlated with the plasma triacylglycerol response. Am J Clin Nutr 2007; 86: 759-67.

12. Ramos MP, Crespo-Solans MD, Del Campo S, Cacho J, Herrera E. Fat accumulation in the rat during early pregnancy is modulated by enhanced insulin responsiveness. Am J Physiol Endocrinol Metab 2003; 285: E318-E328.

13. Magnusson-Olsson AL, Lager S, Jacobsson B, Jansson T, Powell TL. Effect of maternal triglycerides and free fatty acids on placental LPL in cultured primary trophoblast cells and in a case of maternal LPL deficiency. Am J Physiol Endocrinol Metab 2007; 293: E24-E30.

14. Cetin I, Alvino G. Intrauterine growth restriction: implications for placental metabolism and transport. A review. Placenta 2009; 30(Suppl. A): S77-S82.

15. Larque E, Krauss-Etschmann S, Campoy C, Hartl D, Linde J, Klingler M, Demmelmair H, Cano A, Gil A, Bondy B, Koletzko B. Docosahexaenoic acid supply in pregnancy affects placental expression of fatty acid transport proteins. Am J Clin Nutr 2006; 84: 853-61.

16. Hanebutt FL, Demmelmair H, Schiessl B, Larque E, Koletzko B. Long-chain polyunsaturated fatty acid (LC-PUFA) transfer across the placenta. Clin Nutr 2008; 27: 685-93.

17. Ozias MK, Carlson SE, Levant B. Maternal parity and diet (n- 3) polyunsaturated fatty acid concentration influence accretion of brain phospholipid docosahexaenoic acid in developing rats. J Nutr 2007; 137: 125-9.

18. Levant B, Radel JD, Carlson SE. Reduced brain DHA content after a single reproductive cycle in female rats fed a diet deficient in N-3 polyunsaturated fatty acids. Biol Psychiatry 2006; 60: 987-90.

19. Torres N, Bautista CJ, Tovar AR, Ordaz G, Rodriguez-Cruz M, Ortiz V, Granados O, et al. Protein restriction during pregnancy affects maternal liver lipid metabolism and fetal brain lipid composition in the rat. Am J Physiol Endocrinol Metab 2009;

20. Zhou Y, Nijland M, Miller M, Ford S, Nathanielsz PW, Brenna JT. The influence of maternal early to mid-gestation nutrient restriction on long chain polyunsaturated fatty acids in fetal sheep. Lipids 2008; 43: 525-31.

21. McCann JC, Ames BN. Is docosahexaenoic acid, an n-3 longchain polyunsaturated fatty acid, required for development of normal brain function? An overview of evidence from cognitive and behavioral tests in humans and animals. Am J Clin Nutr 2005; 82: 281-95.

22. Calderon F, Kim HY. Docosahexaenoic acid promotes neurite growth in hippocampal neurons. J Neurochem 2004; 90: 979-88.

23. Jensen CL. Effects of n-3 fatty acids during pregnancy and lactation. Am J Clin Nutr 2006; 83: 1452S-1457S.

24. Ander BP, Dupasquier CM, Prociuk MA, Pierce GN. Polyunsaturated fatty acids and their effects on cardiovascular disease. Exp Clin Cardiol 2003; 8: 164-72.

25. Marszalek JR, Lodish HF. Docosahexaenoic acid, fatty acid-interacting proteins, and neuronal function: breastmilk and fish are good for you. Annu Rev Cell Dev Biol 2005; 21: 633-57.

26. Herrera E. Implications of dietary fatty acids during pregnancy on placental, fetal and postnatal development a review. Placenta 2002; 23(Suppl. A): S9-S19.

27. Wathes DC, Abayasekara DR, Aitken RJ. Polyunsaturated fatty acids in male and female reproduction. Biol Reprod 2007; 77: 190-201.

28. Holub DJ, Holub BJ. Omega-3 fatty acids from fish oils and cardiovascular disease. Mol Cell Biochem 2004; 263: 217-25.

29. Levant B, Ozias MK, Carlson SE. Diet (n-3) polyunsaturated fatty acid content and parity interact to alter maternal rat brain phospholipid fatty acid composition. J Nutr 2006; 136: 2236-42.

30. Denomme J, Stark KD, Holub BJ. Directly quantitated dietary (n-3) fatty acid intakes of pregnant Canadian women are lower than current dietary recommendations. J Nutr 2005; 135: 206-11.

31. Teraoka N, Kawashima H, Shiraishi-Tateishi A, Tanaka T, Nakamura J, Kakutani S, Kiso Y. Oral supplementation with dihomo-gamma-linolenic acid-enriched oil altered serum fatty acids in healthy men. Biosci Biotechnol Biochem 2009; 73: 1453-5.

32. Duttaroy AK. Fetal growth and development: roles of fatty acid transport proteins and nuclear transcription factors in human placenta. Indian J Exp Biol 2004; 42: 747-57.

33. Wakefield SL, Lane M, Schulz SJ, Hebart ML, Thompson JG, Mitchell M. Maternal supply of omega-3 polyunsaturated fatty acids alter mechanisms involved in oocyte and early embryo development in the mouse. Am J Physiol Endocrinol Metab 2008; 294: E425-E434.

34. Peng Y, Zhou T, Wang Q, Liu P, Zhang T, Zetterstrom R, Strandvik B. Fatty acid composition of diet, cord blood and breast milk in Chinese mothers with different dietary habits. Prostaglandins Leukot Essent Fatty Acids 2009; 81: 325-30.

35. Tappia PS, Nijjar MS, Mahay A, Aroutiounova N, Dhalla NS. Phospholipid profile of developing heart of rats exposed to low-protein diet in pregnancy. Am J Physiol Regul Integr Comp Physiol 2005; 289: R1400-R1406.

36. De Groot RH, Hornstra G, van Houwelingen AC, Roumen F. Effect of alpha-linolenic acid supplementation during pregnancy on maternal and neonatal polyunsaturated fatty acid status and pregnancy outcome. Am J Clin Nutr 2004; 79: 251-60.

37. Cetin I, Koletzko B. Long-chain omega-3 fatty acid supply in pregnancy and lactation. Curr Opin Clin Nutr Metab Care 2008; 11: 297-302.

38. Wahle KW, Rotondo D, Heys SD. Polyunsaturated fatty acids and gene expression in mammalian systems. Proc Nutr Soc 2003; 62: 349-60.

39. Jump DB. Fatty acid regulation of gene transcription. Crit Rev Clin Lab Sci 2004; 41: 41-78.

40. Greiner RS, Catalan JN, Moriguchi T, Salem N, Jr. Docosapentaenoic acid does not completely replace DHA in n-3 FA-deficient rats during early development. Lipids 2003; 38: 431-5.

41. Helland IB, Smith L, Saarem K, Saugstad OD, Drevon CA. Maternal supplementation with very-long-chain n-3 fatty acids during pregnancy and lactation augments children’s IQ at 4 years of age. Pediatrics 2003; 111: e39-44.

42. Makrides M, Gibson RA. Long-chain polyunsaturated fatty acid requirements during pregnancy and lactation. Am J Clin Nutr 2000; 71: 307S-311S.

43. Martin-Gronert MS, Ozanne SE. Programming of appetite and type 2 diabetes. Early Hum Dev 2005; 81: 981-8.

44. Zambrano E, Bautista CJ, Deas M, Martinez-Samayoa PM, Gonzalez-Zamorano M, Ledesma H, et al. A low maternal protein diet during pregnancy and lactation has sex- and window of exposure-specific effects on offspring growth and food intake, glucose metabolism and serum leptin in the rat. J Physiol 2006; 571: 221-30.

45. Bautista CJ, Boeck L, Larrea F, Nathanielsz PW, Zambrano E. Effects of a maternal low protein isocaloric diet on milk leptin and progeny serum leptin concentration and appetitive behavior in the first 21 days of neonatal life in the rat. Pediatr Res 2008; 63: 358-63.

46. Llorente AM, Jensen CL, Voigt RG, Fraley JK, Berretta MC, Heird WC. Effect of maternal docosahexaenoic acid supplementation on postpartum depression and information processing. Am J Obstet Gynecol 2003; 188: 1348-53.

47. Otto SJ, de Groot RH, Hornstra G. Increased risk of postpartum depressive symptoms is associated with slower normalization after pregnancy of the functional docosahexaenoic acid status. Prostaglandins Leukot Essent Fatty Acids 2003; 69: 237-43.

48. Freeman MP, Hibbeln JR, Wisner KL, Brumbach BH, Watchman M, Gelenberg AJ. Randomized dose-ranging pilot trial of omega-3 fatty acids for postpartum depression. Acta Psychiatr Scand 2006; 113: 31-5.

49. Mamalakis G, Kiriakakis M, Tsibinos G, Kafatos A. Depression and adipose polyunsaturated fatty acids in an adolescent group. Prostaglandins Leukot Essent Fatty Acids 2004; 71: 289-94.

50. Hoffman DR, DeMar JC, Heird WC, Birch DG, Anderson RE. Impaired synthesis of DHA in patients with X-linked retinitis pigmentosa. J Lipid Res 2001; 42: 1395-401.

51. Horrobin DF. Essential fatty acid metabolism and its modification in atopic eczema. Am J Clin Nutr 2000; 71: 367S-372S.

52. Logan AC. Omega-3 fatty acids and major depression: a primer for the mental health professional. Lipids Health Dis 2004; 3: 25.