Gamba G

Idioma: Español
Referencias bibliográficas: 16
Paginas: 414-418
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FRAGMENTO

En el mes de junio tuvimos la visita de Steve Hebert que impartió la sesión general del Instituto el viernes 14 por la mañana con una presentación que mostró, lo que en opinión de algunos podría ser, uno de los desarrollos más rápidos de un trabajo de laboratorio que llega a la clínica y de ahí brinca a la salud pública. Steve habló ese día del papel del sensor de calcio en la función gastrointestinal y su posible utilidad en el tratamiento de la diarrea secretora. Pero vayamos por partes para entender la historia.

REFERENCIAS (EN ESTE ARTÍCULO)

1. Stewart AF. Translational implications of the parathyroid calcium receptor. N Engl J Med 2004; 351(4): 324-6.

2. Gamba G, Saltzberg SN, Lombardi M, Miyanoshita A, Lytton J, Hediger MA, et al. Primary structure and functional expression of a cDNA encoding the thiazidesensitive, electroneutral sodium-chloride cotransporter. Proc Natl Acad Sci USA 1993; 90: 2749-53.

3. Gamba G, Miyanoshita A, Lombardi M, Lytton J, Lee WS, Hediger MA, et al. Molecular cloning, primary structure and characterization of two members of the mammalian electroneutral sodium- (potassium)-chloride cotransporter family expressed in kidney. J Biol Chem 1994; 269: 17713-22.

4. Ho K, Nichols CG, Lederer J, Lytton J, Vassilev PM, Kanazirska MV, et al. Cloning and expression of an inwardly rectifying ATP-regulated potassium channel. Nature 1993; 362: 31-8.

5. Brown E M, Gamba G, Riccardi D, Lombardi M, Butters R, Kifor O, et al. Cloning and characterization of an extracellular Ca2+ sensing receptor from bovine parathyroid. Nature 1993; 366: 575-80.

6. Block GA, Martin KJ, de Francisco AL, Turner SA, Avram MM, Suranyi MG, et al. Cinacalcet for secondary hyperparathyroidism in patients receiving hemodialysis. N Engl J Med 2004; 350(15): 1516-25.

7. Shoback DM, Bilezikian JP, Turner SA, McCary LC, Guo MD, Peacock M. The calcimimetic cinacalcet normalizes serum calcium in subjects with primary hyperparathyroidism. J Clin Endocrinol Metab 2003; 88(12): 5644-9.

8. Nearing J, Betka M, Quinn S, Hentschel H, Elger M, Baum M, et al. Polyvalent cation receptor proteins (CaRs) are salinity sensors in fish. Proc Natl Acad Sci USA 2002; 99(14): 9231-6.

9. Diaz R, Hurwitz S, Chattopadhyay N, Pines M, Yang Y, Kifor O, et al. Cloning, expression, and tissue localization of the calcium-sensing receptor in chicken (Gallus domesticus). Am J Physiol (Regulatory Integrative Comp Physiol) 1997; 273: R1008-R1016.

10. Cima RR, Cheng I, Klingensmith ME. Chattopadhyay N, Kifor O, Hebert SC, et al. Identification and functional assay of an extracellular calcium-sensing receptor in Necturus gastric mucosa. Am J Physiol 1997; 273(5 Pt 1): G1051-G1060.

11. Cheng SX, Okuda M, Hall AE, Geibel JP, Hebert SC. Expression of calcium-sensing receptor in rat colonic epithelium: evidence for modulation of fluid secretion. Am J Physiol Gastrointest Liver Physiol 2002; 283(1): G240-G250.

12. Rutten MJ, Bacon KD, Marlink KL, Stoney M, Meichsner CL, Lee FP, et al. Identification of a functional Ca2+-sensing receptor in normal human gastric mucous epithelial cells. Am J Physiol 1999; 277(3 Pt 1): G662-G670.

13. Busque SM, Kerstetter JE, Geibel JP, Insogna K. L-type amino acids stimulate gastric acid secretion by activation of the calcium-sensing receptor in parietal cells. Am J Physiol Gastrointest Liver Physiol 2005; 289(4): G664-G669.

14. Chen SX, Geibel J, Hebert SC. Extracellular Polyamines Regulate Fluid Secretion in Rat Colonic Crypts Via the Extracellular Calcium-Sensing Receptor. Gastroenterology 2004; 126: 148-58.

15. Geibel J, Sritharan K, Geibel R, Geibel P, Persing JS, Seeger A, et al. Calciumsensing receptor abrogates secretagogue induced increases in intestinal net fluid secretion by enhancing cyclic nucleotide destruction. Proc Natl Acad Sci USA 2006; 103: 9390-7.

16. Kirchhoff P, Geibel J. Role of calcium and other trace elements in the gastrointestinal physiology. World J Gastroenterol 2006; 12: 3229-36.