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Colegio de Medicina Interna de México.

2013, Número 1

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Med Int Mex 2013; 29 (1)


Enfermedad relacionada con IgG4

Carrillo ER, Echeverría VJA

Idioma: Español
Referencias bibliográficas: 57
Paginas: 53-61
Archivo PDF: 193.09 Kb.


RESUMEN

La enfermedad relacionada con la IgG4 es de descripción reciente y se caracteriza por fibrosis inflamatoria acompañada, o no, de concentraciones séricas de IgG4 elevadas. Desde el punto de vista clínico, la enfermedad puede manifestarse con afectación de un solo o de múltiples órganos. Se ha propuesto que esta enfermedad es secundaria a la interacción entra células Th2 y células B, que resulta en concentraciones elevadas de IgG4 y de mediadores inflamatorios, eventos que se expresan a nivel tisular como infiltrados linfoplasmocitarios y fibrosis; sin embargo, aparentemente no es el único mecanismo involucrado en la fisiopatología de la enfermedad. Para el diagnóstico es necesaria la combinación de elementos clínicos, serológicos, histopatológicos e inmunohistoquímicos. En general, se ha observado buena respuesta al tratamiento con glucocorticoides; sin embargo, se están probando terapias alternativas para casos de resistencia al tratamiento de primera línea.


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