Belkind-Gerson J, Suárez-Rodríguez R

Idioma: Español
Referencias bibliográficas: 20
Paginas: 201-207
Archivo PDF: 141.65 Kb.

RESUMEN

Existe una amplia gama en el límite de la capacidad que poseen los organismos vivos para la regeneración de tejidos lesionados. El ejemplo más dramático en los vertebrados es la salamandra, la cual puede tener una regeneración completa de cola, extremidades, ojo, mandíbula y corazón. En el humano, hallazgos recientes sugieren que aun en el tejido nervioso, donde anteriormente se creía no había capacidad de regeneración, parecen existir mecanismos importantes para restaurar el tejido neural lesionado. Esta es una revisión sobre la evidencia experimental que apoya la regeneración nerviosa.

REFERENCIAS (EN ESTE ARTÍCULO)

1. Prockop DJ et al. One strategy for cell and gene therapy: Harnessing the power of adult stem cells to repair tissues. Proc Nat Acad Sci USA 2003; 100 (suppl 1): 11917-11923.

2. Peterson DA. Stem cells in brain plasticity and repair. Cur Op Pharmacol 2002; 2 (1): 34-42.

3. Seaberg RM, Van der Kooy D. Adult rodent neurogenic regions: The ventricular subependyma contains neural stem cells, but the dentate gyrus contains restricted progenitors. J Neuroscience 2002; 22 (5): 1784-1793.

4. Stocum DL. Stem cells in regenerative biology and medicine. Wound Repair Regeneration 2001; 9 (6): 429-442.

5. Theise ND et al. Liver from bone marrow in humans [see comment]. Hepatology 2000; 32 (1): 11-6.

6. Poulsom R et al. Bone marrow contributes to renal parenchymal turnover and regeneration. J Pathology 2001. 195 (2): 229-235.

7. Suratt BT et al. Human pulmonary chimerism after hematopoietic stem cell transplantation [see comment]. Am J Resp Crit Care Med 2003; 168 (3): 318-322.

8. Deb A et al. Bone marrow-derived cardiomyocytes are present in adult human heart: A study of gender-mismatched bone marrow transplantation patients [see comment]. Circulation 2003; 107 (9): 1247-1249.

9. Mezey E et al. Transplanted bone marrow generates new neurons in human brains. Proc Nat Acad Sci USA 2003; 100 (3): 1364-1369.

10. Palmer TD et al. Cell culture. Progenitor cells from human brain after death. Nature 2001; 411 (6833): 42-43.

11. Zhao LR et al. Human bone marrow stem cells exhibit neural phenotypes and ameliorate neurological deficits after grafting into the ischemic brain of rats. Exp Neurol 2002; 174 (1): 11-20.

12. Vescovi A et al. Neural stem cells: plasticity and their transdifferentiation potential. Cells Tissues Organs 2002; 171 (1): 64-76.

13. Herman JP, Abrous ND. Dopaminergic neural grafts after fifteen years: results and perspectives. Prog Neurobiol 1994; 44 (1): 1-35.

14. Olanow CW, Freeman T, Kordower J. Transplantation of embryonic dopamine neurons for severe Parkinson’s disease [see comment]. New Engl J Med 2001; 345 (2): 146; author reply 147.

15. Wechsler LR, Kondziolka D. Cell therapy: Replacement [see comment]. Stroke 2003; 34 (8): 2081-2082.

16. Sorensen JC et al. Fetal neocortical tissue blocks implanted in brain infarcts of adult rats interconnect with the host brain. Exp Neurol 1996; 138 (2): 227-235.

17. Kleppner SR et al. Transplanted human neurons derived from a teratocarcinoma cell line (NTera-2) mature, integrate, and survive for over 1 year in the nude mouse brain. J Comp Neurol 1995; 357 (4): 618-632.

18. Kondziolka D et al. Transplantation of cultured human neuronal cells for patients with stroke [see comment]. Neurology 2000; 55 (4): 565-9.

19. Preston SL et al. The new stem cell biology: something for everyone. Mol Pathol 2003; 56 (2): 86-96.

20. David S, Lacroix S. Molecular approaches to spinal cord repair. An Rev Neuroscience 2003; 26: 411-440.