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Colegio de Medicina Interna de México.

2012, Número 4

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Med Int Mex 2012; 28 (4)


Enfermedad por virus JC

López HMA

Idioma: Español
Referencias bibliográficas: 64
Paginas: 352-359
Archivo PDF: 84.77 Kb.


RESUMEN

La infección por el poliomavirus JC es una entidad poco diagnosticada que ocurre en el contexto de inmunosupresión severa. Existen varios contextos clínicos en los que ocurre la activación y enfermedad por virus JC, como las neoplasias, la infección avanzada por el virus de la inmunodeficiencia humana, la inmunosupresión terapéutica en pacientes trasplantados y, recientemente, en pacientes tratados con anticuerpos monoclonales como rituximab, efalizumab y natlizumab, usados como inmunomoduladores en enfermedades como la enfermedad de Crohn, la esclerosis múltiple, el lupus eritematoso generalizado y la psoriasis. En esta revisión se describen, además de la leucoencefalopatía multifocal progresiva en su forma clásica de presentación, formas de presentación recientemente descritas de infección por virus JC como: el síndrome de reconstitución inmune inflamatoria, tanto en pacientes con infección por VIH que inician tratamiento antirretroviral altamente activo como en pacientes con inmunosupresión por fármacos, la neuronopatía de células granulares, la meningitis y la encefalitis por virus JC.


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