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2011, Número 4

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Biotecnol Apl 2011; 28 (4)


Integración retroviral: Una etapa crítica del ciclo replicativo viral apropiada para intervención terapéutica

Fernández-Ortega C, Ramírez-Suárez A, Paneque-Guerrero T, Casillas-Casanova D

Idioma: Ingles.
Referencias bibliográficas: 32
Paginas: 255-260
Archivo PDF: 160.50 Kb.


RESUMEN

La integración retroviral es una etapa esencial en el ciclo de vida de los retrovirus. Ellos necesitan insertar su material genético en el ADN cromosomal de las células hospederas. La integración retroviral es un proceso complejo donde intervienen proteínas virales y del hospedero y requiere el movimiento del material genético viral desde el citoplasma hasta el núcleo. La integrasa viral es una enzima clave en este proceso que cataliza dos reacciones: El procesamiento 3´ del ADN viral que tiene lugar en el citoplasma después de la transcripción reversa y la transferencia de cadena que inserta el ADN viral en un cromosoma de las células del hospedero. El desarrollo de un tratamiento exitoso contra la infección del VIH con el inhibidor de la transferencia de cadena, Raltegravir, ha demostrado que la integración retroviral es una etapa apropiada para la intervención terapéutica. Actualmente se diseñan diferentes tipos de inhibidores que tienen como blanco la integrasa del VIH o alguno de los otros componentes del proceso de integración retroviral. Este trabajo recoge una reseña del proceso de integración retroviral así como, muchos de los últimos avances en la temática que se expusieron en la recién celebrada IV Conferencia Internacional sobre Integración Retroviral.


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