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2011, Número 3

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Biotecnol Apl 2011; 28 (3)


El tratamiento basado en interferón como terapia adyuvante para los candidatos vacunales contra la infección crónica por el virus de la hepatitis C

Amador-Cañizares Y

Idioma: Ingles.
Referencias bibliográficas: 83
Paginas: 123-129
Archivo PDF: 123.61 Kb.


RESUMEN

Los candidatos vacunales terapéuticos contra el virus de la hepatitis C han demostrado ser inmunogénicos, pero no han sido capaces de inducir la eliminación viral completa. Las evidencias experimentales acumuladas indican que el agotamiento de las células T específicas contra este virus es un obstáculo fundamental, que debe ser salvado si se persigue el control de la infección por parte del sistema inmune. El potencial mostrado por los tratamientos basados en interferón para rescatar la funcionalidad de dichas células, convierte a esta terapia en un candidato promisorio para ser combinado con las estrategias vacunales contra el virus de la hepatitis C. La presente revisión se centra en los principales efectos que tienen las terapias basadas en interferón sobre la respuesta celular específica contra el virus de la hepatitis C, en los pacientes crónicos. Particularmente, se hace énfasis en su potencial para modificar favorablemente la eficacia de los enfoques vacunales terapéuticos para alcanzar una eliminación viral sostenida.


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