2010, Número 1
Siguiente >>
Rev Mex Med Repro 2010; 2.3 (1)
Estimulación ovárica controlada. Tiempo de reevaluar
Pérez PE, Gutiérrez GA, Pérez LE, Rojas RF
Idioma: Español
Referencias bibliográficas: 71
Paginas: 1-9
Archivo PDF: 86.53 Kb.
FRAGMENTO
La estimulación ovárica es determinante en la obtención de resultados en reproducción asistida. Las opciones varían desde el ciclo natural y de mínima estimulación hasta la estimulación convencional con gonadotropinas diversas y análogos de GnRH. La tendencia es regresar a esquemas más viables para evitar complicaciones, que sean a la vez cómodos y accesibles; esto no significa que haya que sacrificar la efectividad, sino que hay que hacer una buena selección de casos y diseñar esquemas terapéuticos a la medida de las pacientes. En este artículo se evalúan indicaciones, ventajas y desventajas de cada modalidad; se analizan controversias tanto en el uso de agonistas o antagonistas de GnRH, como de gonadotrofinas recombinantes o urinarias, y se señalan las nuevas preparaciones disponibles. Un punto fundamental es el uso de coadyuvantes en la estimulación, que bien seleccionados enriquecen el armamentario terapéutico y favorecen una mejor respuesta; entre ellos destacan los anticonceptivos orales, los estrógenos, los sensibilizadores a la acción de la insulina, los andrógenos, las sustancias androgénicas, los corticoides, el ácido acetilsalicílico, los inhibidores de fosfodiesterasa, los agonistas dopaminérgicos y la gonadotropina coriónica.
REFERENCIAS (EN ESTE ARTÍCULO)
Pérez Peña E. Estimulación ovárica controlada. En: Pérez Peña E, editor. Atención integral de la infertilidad. Endocrinología, cirugía y reproducción asistida. 3ª ed. México: McGraw-Hill, 2011 (en prensa).
Pelinck MJ, Hoek A, Simons AHM, Heineman MJ. Efficacy of natural cycle IVF: a review of the literature. Hum Reprod Update 2002;8:129-139.
Kolibiankis E, Zikopoulos K, Camus M, Tournaye, et al. Modified natural cycle for IVF responders does not offer a realistic chance of parenthood in poor responders with high day 3 FSH levels, as a last resort prior to oocyte donation. Hum Reprod 2004;19:2545-2549.
Pérez-Peña E, Gutiérrez-Gutiérrez A, Pascual-Rodríguez A, González-Ortega C. Preservación de la fertilidad. En: Barroso Villa JG, editor. Biología de la reproducción en el siglo XXI. Clin Perinat Reprod Hum 2009;p:121-142.
Cancino VP, González OC, Enríquez FAS, Kohls G, et al. In vitro maturation: A low cost alternative that minimizes risks in ART. RBM Online 2008;17(Suppl 2):P-03,S-34.
Al-Fozan H, Al-Khadouri M, Tan SL, Tulandi T. A randomized trial of letrozole versus clomiphene citrate in women undergoing superovulation. Fertil Steril 2004;82:1561-1563.
Mitwally MFM, Casper RF. Use of an aromatase inhibitor for induction of ovulation in patients with an inadequate response to clomiphene citrate. Fertil Steril 2001;75:305-309.
Mitwally MFM, Casper RF. Aromatase inhibition reduces gonadotrophin dose required for controlled ovarian stimulation in women with unexplained infertility. Hum Reprod 2003;18:1588-1597.
Mitwally MFM, Casper RF. Aromatase inhibition improves ovarian response to follicle-stimulating hormone in poor responders. Fertil Steril 2002;77:776-780.
Aanesen A, Nygren KG, Nylund L. Modified natural cycle and mild IVF: a 10 year Swedish experience. RBM Online 2010;20:156-162.
Teramoto S. Minimal stimulation with clomiphene citrate: a large-scale retrospective study. RBM On line 2007;15:137-148.
May JV. Ovarian hyperstimulation. Effects on oocyte quality and communication between physician and embryologist to optimize oocyte quality. Infertil Reprod Med 1998;9:163-179.
Garza MA, Cavazos MT, Garza RH, Antagonistas de GnRH. En: Vázquez Benítez E, editor. Medicina reproductiva. 2ª ed. México: El Manual Moderno, 2003;p:341-352.
Al-Inany HG, Aboulghar M, Mansour R, Proctor M. Recombinant versus urinary human chorionic gonadotrophin for ovulation induction in assisted conception. Cochrane Database of Systematic Reviews. In: The Cochrane Library, 2009, Issue 3, Art. CD003719. DOI: 10.1002/14651858.CD003719.pub2
Westergaard LW, Bossuyt PMM, van der Veen F, van Wely M. Human menopausal gonadotropin versus recombinant follicle stimulation hormone for ovarian stimulation in assisted reproductive cycles. Cochrane Database of Systematic Reviews. In: The Cochrane Library, 2009, Issue 3, Art.CD003973. DOI: 10.1002/14651858.CD003973.pub1
Coomarsamy A, Afnan M, Cheema D, van der Veen F, et al. Urinary hMG versus recombinant FSH for controlled ovarian hyperstimulation following an agonist long down-regulation protocol in IVF or ICSI treatment: a systematic review and meta-analysis. Hum Reprod 2008;23:310-315.
Daya S. Updated meta-analysis of recombinant folliclestimulating hormone (FSH) versus urinary FSH for ovarian stimulation in assisted reproduction. Fertil Steril 2002;77:711-714.
Daya S, Gunby J. Recombinant versus urinary follicle stimulating hormone for ovarian stimulation in assisted reproduction cycles. Cochrane Database Syst Rev 2000:CDOO2810.
Arslan M, Bocca S, Mirkin S, Barroso G, et al. Controlled ovarian hyperstimulation protocols for in vitro fertilization: two decades of experience after the birth of Elizabeth Carr. Fertil Steril 2005;84:555-569.
Driebergen R, Baer G. Quantification of follicle stimulating hormone (follitropin alfa): is in vitro bioassay still relevant in the recombinant age? Curr Med Res Opin 2003;19:41-46.
Oberyé J, Passier D, Mahony M, Mannaerts B, Bonduelle M. Succesful corifollitropin alfa treatment resulting in 500 hundred live-born infants to date. Fertil Steril 2010;93:S18.
Devroey P, Kuper NP, Mannaerts BMJL, Jzerman PC, Fauser BCJM. A double blind, non inferiority RCT comparing corifollitropin alfa and recombinant FSH during the first seven days of ovarian stimulation using a GnRH antagonist protocol. Hum Reprod 2009;20:3063-3072.
Devroey P, Fauser BC, Plattteau P, Becker NG, et al. Induction of multiple follicular development by a single dose of long-acting recombinant follicle-stimulating hormone (FSH-CTP, corifollitropin alfa) for controlled ovarian stimulation before in vitro fertilization. J Clin Endocrinol Metab 2004;89:2062-2070.
Howles CM. Recombinant gonadotropins in reproductive medicine: the gold standard of today. Reprod Biomed Online 2006;12:11-13.
van Wely M, Westergaard LG, Bossuyt PMM, van der Veen F. Effectiveness of human menopausal gonadotropin versus recombinant follicle stimulating hormone for controlled ovarian hyperstimulation in assisted reproductive cycles. A meta-analysis. Fertil Steril 2003;80:1086-1093.
Al-Inani H, Aboughar M, Mansour R, Serour G. Metaanalysis of recombinant versus urinary-derived FSH: an update. Hum Reprod 2003;18:305-313.
van de Weijer BH, Mulders JW, Bos ES, Verhaert PD, et al. Compositional analyses of a human menopausal gonadotropin preparation extracted from urine (menotropin). Identification of some of its major impurities. Reprod Biomed Online 2003;7:547-557.
Giudice E, Crisci C, Altarocca V, O’Brien M. Characterization of a partially purified human menopausal gonadotropin preparation. J Clin Res 2001;4:27-33.
Griesinger G, Schultze-Mosgau A, Dafopoulos K, Schroeder A, et al. Recombinant luteinizing hormone supplementation to recombinant follicle-stimulating hormone induced ovarian hyperstimulation in the GnRH-antagonist multiple-dose protocol. Hum Reprod 2005;20:1200-1206.
Kolibianakis EM, Collins J, Tarlatzis B, Papanikolau E, Devroey P. Are endogenous LH levels during ovarian stimulation for IVF using GnRH analogues associated with the probability of ongoing pregnancy? A systematic review. Hum Reprod Update 2006;12:3-12.
Cedrin-Durnerin I. Antagonist protocols: residual LH levels and the value of exogenous LH supplementation. J Gynecol Obstet Biol Reprod (Paris) 2004;33:3S29-31.
Filicori M, Cognini GE, Taraborrelli D, Spettoli D, et al. Luteinizing hormone activity supplementation enhances follicle-stimulating hormone efficacy and improves ovulation induction outcome. J Clin Endocrinol Metab 1999;84:2659-2663.
Ludwig M. Does the addition of luteinizing hormone in ovarian stimulation protocols improve the outcome. Treat Endocrinol 2003;2:305-313.
Filicori M, Cognini GE, Taraborrelli S, Spettoli D, et al. Low-dose human chorionic gonadotropin therapy can improve sensitivity to exogenous follicle-stimulating hormone in patients with secondary amenorrhea. Fertil Steril 1999;72:1118-1120.
Meldrum D. Pituitary control: GnRH agonists or antagonists. Middle East Fertil Soc J 2003:8:4-5.
Pinkas H, Sapir O, Avrech OM, Ben-Haroush A, et al. The effect of oral contraceptive pill for cycle scheduling prior to GnRH antagonist protocol on IVF cycle parameters and pregnancy outcome. J Ass Reprod Genet 2008;25:29-34.
Biljan MM, Mahutte NG, Dean N, Hemmings R, et al. Effects of pretreatment with an oral contraceptive on the time required to achieve pituitary suppression with gonadotropin-releasing hormone analogues and on subsequent implantation and pregnancy rates. Fertil Steril 1998;70:1063-1069.
De Ziegler D, Jaaskelainen AS, Brioschi PA, Fanchin R, Bulletti C. Synchronization of endogenous and exogenous FSH stimuli in controlled ovarian hyperstimulation (COH). Hum Reprod 1998;13:561-564.
Fanchin R, Solomon L, Castelo-Branco A, Olivennes F, et al. Luteal estradiol pre-treatment coordinates follicular growth during controlled ovarian hyperstimulation with GnRH antagonists. Hum Reprod 2003;18:2698-2703.
Fratarelli JL, Hill MJ, McWilliams GD, Miller KA, et al. A luteal estradiol protocol for expected poor responders improves embryo numbers and quality. Fertil Steril 2008;89:1118-1122.
Patel SS, Beshay VE, Carr BR. Metformin for the treatment of polycystic ovary syndrome. In: Carrell DT, Racowsky C, Schlegel PN, Van Voorhis BJ, editors. Biennial Review of Infertility. Vol. 1. New York: Springer, 2009;p:21-28.
Costello MF, Chapman M, Conway U. A systematic review and meta-analysis of randomized controlled trials on metformin co-administration during gonadotrophin ovulation induction for IVF in women with polycystic ovary syndrome. Hum Reprod 2006;21:1387-1399.
Agrawal R, Jacobs H, Payne N, Conway G. Concentration of vascular endothelial growth factor released by cultured luteinized granulose cells is higher in women with polycystic ovaries than in women with normal ovaries. Fertil Steril 2002;78:1164-1169.
Meldrum DR. Vascular endotelial growth factor, polycystic ovary syndrome, and ovarian hyperstimulation syndrome. Fertil Steril 2002;78:1170-1171.
Palomba S, Orio F, Falbo A. Prospective parallel randomized, double-blind, double-dummy, controlled clinical trial comparing clomiphene citrate and metformin as the first-line treatment for ovulation induction in non obese anovulatory women with polycystic ovary syndrome. J Clin Endocrinol Metab 2005;90:4068-4074.
Tang T, Glanville J, Orsi N, Barth JH, Balen AH. The use of metformin for women undergoing IVF treatment. Hum Reprod 2006;21:1416-1425.
Harper K, Proctor M, Hughes E. Growth hormone for in vitro fertilization. Cochrane Database Syst Rev 2003;3:1-33.
Creanga AA, Bradley HM, Witkop CP. Use of metformin in polycystic ovary syndrome: a meta-analysis. Obstet Gynecol 2008;111:959-968.
Jakubowics DJ, Seppala M, Jakubowics S, et al. Insulin reduction with metformin increases luteal phase serum gycodelin and insulin-like growth factor-binding protein 1 concentration and enhances uterine vascularity and blood flow in the polycystic ovary syndrome. J Clin Endocrinol Metab 2001;86:1126-1133.
Bencomo E, Pérez R, Arteaga MF, Acosta E, et al. Apoptosis of cultured granulosa-lutein cells is reduced by insulin growth factor I and may correlate with embryo fragmentation and pregnancy rate. Fertil Steril 2006;85:474-480.
Kolibiankis EM, Venetis CA, Diedrich K, Tarlatzis BC. Addition of growth hormone to gonadotrophins in ovarian stimulation of poor responders treated by in vitro fertilization: a systematic review and meta-analysis. Hum Reprod Update 2009;15:613-622.
Schoolcraft W, Schlenker T, Gee M, Stevens J, Wagley L. Improved controlled ovarian hyperstimulation in poor responder in vitro fertilization patients with microdose folliclestimulating hormone flare, growth hormone protocol. Fertil Steril 1997;67:93-97.
Tesarik J, Hazout A, Mendoza C. Improvement of delivery and live birth rates after ICSI in women aged >35 years by ovarian co-stimulation with growth hormone. Hum Reprod 2005;20:2536-2541.
Lewicka S, von Hagens C, Hettinger U, Grunwald K, et al. Cortisol and cortisone in human follicular fluid and serum and the outcome of IVF treatment. Hum Reprod 2003;18:1613-1617.
Keay SD, Lenton EA, Cooke ID, Hull MGR, Jenkins JM. Low dose dexamethasone augments the ovarian response to exogenous gonadotropins leading to a reduction in cycle cancellation rate in a standard IVF programme. Hum Reprod 2001;16:1861-1865.
Thompson KA, La Pott PS, Rivier J, Henderson G, et al. Gonadotropin requirements of the developing follicle. Fertil Steril 1995;63:273-276.
Gutiérrez GA, Pérez PE. Fisiología de la LH en un ciclo natural. En: Bellver PJ, Requena MA, editores. Manual práctico sobre el uso de la hormona luteinizante en reproducción asistida. Vol. 1. Plaza Edición: Buenos Aires, 2008;p:1-6.
Álvarez C, Alonso-Muriel I, García G, Crespo J, et al. Implantation is apparently unaffected by the dopamine agonist cabergoline when administered to prevent ovarian hyperstimulation syndrome in women undergoing assisted reproduction treatment: a pilot study. Hum Reprod 2007;22:3210-3214.
Álvarez C, Marti-Bonmati L, Novella-Maestre E, Sanz R, et al. Dopamine agonist carbergoline reduces hemoconcentration and ascitis in hyperstimulated women undergoing assisted reproduction. J Clin Endocrinol Metab 2007;92:2931-2937.
Barad D, Brill H, Gleicher N. Update on the use of dehydroepiandrosterone supplementation among women with diminished ovarian function. J Ass Reprod Genet 2007;24:629-634.
Massin N, Cedrin-Durnerin I, Coussieu C, Galey-Fontaine J, et al. Effects of transdermal testosterone application on the ovarian response to FSH in poor responders undergoing assisted reproduction technique. A prospective, randomized, double-blind study. Hum Reprod 2006;21:1204-1211.
García-Velasco JA, Moreno L, Pacheco A, Guillén A, et al. The aromatase inhibitor letrozole increases the concentration of ovarian androgens and improves in vitro fertilization outcome in low responder patients: a pilot study. Fertil Steril 2005;84:82-87.
Balasch J, Fabregues F, Peñarrubia J, Carmona F, et al. Pretreatment with transdermal testosterone may improve ovarian response to gonadotrophins in poor responders IVF patients with normal basal concentrations of FSH. Hum Reprod 2006;21:1884-1893.
Rubinstein M, Marazzi A, Polak de Fried E. Low-dose aspirin treatment improves ovarian responsiveness, uterine and ovarian flow velocity, implantation and pregnancy rates in patients undergoing in vitro fertilization: a prospective, randomized, double-blind placebo-controlled study. Fertil Steril 1999;71:825-829.
Waldenstrom U, Hellberg D, Nilsson S. Low dose aspirin in a short regime as a standard treatment in in vitro fertilization: a randomized, prospective study. Fertil Steril 2004;81:1560-1564.
Khary M, Banerjee K, El-Toukhy T, Coomarasamy A, Khalaf Y. Aspirin in women undergoing in vitro fertilization treatment: a systematic review and meta-analysis. Fertil Steril 2007;88:822-831.
Ruop MD, Collins TC, Whitcomb BW, Schisterman EF. Evidence of absence or absence of evidence? A reanalysis of the effects of low dose aspirin in in vitro fertilization. Fertil Steril 2008;90:71-76.
Takasaki A, Tamura H, Miwa I, Taketani T, et al. Endometrial growth and uterine blood flow: a pilot study for improving endometrial thickness in the patients with a thin endometrium. Fertil Steril 2010;93(6):1851-1858.
Sher G, Fisch JD. Effects of vaginal sildenafil on the outcome of in vitro fertilization (IVF) after multiple IVF failures attributed to poor endometrial development. Fertil Steril 2002;78:1073-1076.
Sher G, Fisch JD. Vaginal sildenafil (Viagra): a preliminary report of a novel method to improve uterine artery blood flow and endometrial development in patients undergoing IVF. Fertil Steril 2000;15:806-809.
Check JH, Graziano V, Lee G, Nazari A, et al. Neither sildenafil nor vaginal estradiol improves endometrial thickness in women with thin endometrium after taking oral estradiol in graduating dosages. Clin Exp Obstet Gynecol 2004;31:99-102.