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2012, Número 3

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Gac Med Mex 2012; 148 (3)


Nuevos anticoagulantes: dabigatrán, rivaroxabán y apixabán

Vargas RÁG, Ramírez LAN, Medina VME

Idioma: Español
Referencias bibliográficas: 37
Paginas: 257-264
Archivo PDF: 90.79 Kb.


RESUMEN

Hasta hoy, los medicamentos más utilizados en nuestras clínicas de anticoagulación son la acenocumarina y la warfarina, que pertenecen a la categoría de antagonistas de la vitamina K (AVK). Tienen cerca de 70 años de uso en la clínica, con probada eficacia para distintas enfermedades trombóticas, aunque también con conocidos problemas derivados de su variabilidad e interacciones farmacológicas y dietéticas. En tromboprofilaxis hospitalaria, la enoxaparina es el anticoagulante más utilizado, una heparina de bajo peso molecular (HBPM). Una nueva generación de anticoagulantes está disponible, los inhibidores directos de la trombina (como dabigatrán) y del factor Xa (rivaroxabán y apixabán), con evidentes ventajas sobre los anticoagulantes convencionales. En este artículo se resume lo publicado hasta el momento para estos nuevos antitrombóticos.


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