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Instituto Nacional de Salud Pública

2012, Número 4

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salud publica mex 2012; 54 (4)


Asociación inversa entre asma y defectos del tubo neural: estudio ecológico binacional

Vargas MH, Campos-Bedolla P, Segura P

Idioma: Español
Referencias bibliográficas: 35
Paginas: 418-424
Archivo PDF: 387.34 Kb.


RESUMEN

Objetivo. Los donadores de metilo como el ácido fólico previenen defectos del tubo neural (DTN), pero estudios recientes sugieren que también favorecen el desarrollo de asma. En este trabajo exploramos una posible asociación ecológica entre DTN y asma. Material y métodos. Se consultaron bases de datos de México y EUA para obtener información sobre distribución geográfica (por estado) y tendencia temporal (por año) de DTN y asma. Resultados. Los estados con menor frecuencia de DTN tuvieron mayor frecuencia de asma, tanto en México (rS=-0.48, p=0.005) como en EUA (rS=-0.39, p=0.005). Las tendencias temporales también mostraron correlación inversa en México (1997-2007, rS=-0.73, p=0.01) y EUA (1979-1998, rS=-0.91, p‹0.001). Conclusiones. En ambos países la frecuencia de asma correlacionó de forma inversa con la frecuencia de DTN, tanto en distribución geográfica como en tendencias anuales, apoyando la posibilidad de que la ingestión de donadores de metilo en la dieta o como suplementos esté influyendo sobre la frecuencia de asma.


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