2003, Número 3
Receptores estrogénicos alfa y beta en cáncer de mama
Sánchez-Suárez P, Benítez-Bribiesca L
Idioma: Español
Referencias bibliográficas: 26
Paginas: 159-161
Archivo PDF: 45.01 Kb.
FRAGMENTO
La relación entre el cáncer de mama y los estrógenos se conoce desde hace más de 100 años, cuando Beatson sugirió que las secreciones provenientes del ovario eran las responsables del crecimiento del cáncer de mama en mujeres premenopáusicas, demostrando que la ooforectomía bilateral producía una marcada reducción del tamaño del tumor. Actualmente numerosos estudios han comprobado el papel de los estrógenos tanto endógenos como exógenos, en la patogenia del cáncer de mama.
REFERENCIAS (EN ESTE ARTÍCULO)
Clemons M, Goss P. Mechanisms of disease: Estrogen and the risk of breast cancer. N Engl J Med 2001; 344(4): 276-285.
Topper YJ, Freman CS. Multiple hormone interactions in the developmental biology of the mammary gland. Physiol Rev 1980; 60: 1049-106.
Persson I. Estrogens in the causation of breast, endometrial and ovarian cancers-evidence and hypothesis from epidemiological findings. J Steroid Biochem Mol Biol 2000; 74(5): 357-64.
Schneider HP, Jackkish C. Potential benefits of estrogen and progestogens on breast cancer. Int J Fertil Women Med 1998; 43(6): 278-85.
Pathak DR, Osuch JR, He J. Breast carcinoma Etiology: Current knowledge and new insights into the effects of reproductive and hormonal risk factors in black and white populations. In: National Action Plan on Breast Cancer Workshop on Multicultural Aspects of Breast Cancer etiology. Cancer 2000; 1(88): 1230-8.
Marchetti E, Querzoli P, Marzola A, Bagni, Ferretti S, Fabris G, et al. Assessment of proliferative rate of breast cancer by Ki67 monoclonal antibody. Mol Pathol 1990; 3: 31-35.
McGuire WL, Carbone PP, Vollmer EP eds. Estrogen receptors in human breast cancer. New York: Raven Press 1975.
Greene GL, Nolan C, Engler JP, Jensen EV. Monoclonal antibodies to human estrogen receptor. Proc Natl Acad Sci 1980; 77: 5115-5119.
Benítez Bribiesca, Guevara R, Ruiz T, Martínez, Rodríguez Cuevas. A simplified histoscore for the estrogen receptor assay in breast cancer. Path Res Pract 1992; 188: 461-465.
Heubner A, Beck T, Grill HJ, Pollow K. Comparison of immunocytochemical estrogen receptor assay, estrogen receptor enzyme immunoassay, and radioligand labeled estrogen receptor assay in human breast cancer and uterine tissue. Cancer Res Suppl 1986; 46: 4191- 4295.
Green S, Walter P, Kumar V, Krust A, Bornet JM, Argos P, et al. Human estrogen receptor cDNA sequence, expression and homology to v-erb-A. Nature 1986; 320: 134-9.
Tremblay GB, Trembaly A, Copeland NG, Gilbert DK, Jekins NA, Labrie F, et al. Cloning, chromosomal localization, and functional analysis of the murine estrogen receptor (beta). Mol Endocrinol 1997; 11: 353-65.
Mosselman S, Polman J, Dijkrma R. ER-b: Identification and characterization of a novel human estrogen receptor. FEBS Lett 1996; 392: 49-53.
Speirs V, Kerin MJ. Prognostic significance of estrogen receptor (beta) in breast cancer. Br J Surg 2000; 87: 405-409.
Kuiper GG, Carlsson B, Grandien K, Enmark E, Haggblad J, Nilsson S, et al. Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors (alpha) and (beta). Endocrinology 1997; 138: 863-70.
Cowley SM, Hoare S, Mosselman S, Parker MG. Estrogen receptors (alpha) and (beta) form heterodimers on DNA. J Biol Chem 1997; 272: 858-62.
George GJ, Jan-Aike Gustafsson. The novel estrogen receptor-b subtype: potential role in the cell-and promoter- specific actions of estrogens and anti-estrogens. FEBS Lett 1997; 410: 87-90.
Pace P, Taylor J, Suntharalingam S, Coombes RC, Ali S. Human estrogen receptor (beta) binds DNA in a manner similar to and dimerizes with estrogen receptor (alpha). J Biol Chem 1997; 272: 25 832-8.
Leygue E, Dotzlaw H, Watson PH, Murphy LC. Expression of estrogen receptor b1, b2 and b5 messenger RNAs in Human breast tissue. Cancer Res 1999; 59: 1175-1179.
Janice M, Julia MWG, Robertson FR, Ian OE, Robert IN. A possible divergent role for the estrogen receptor alpha and beta subtypes in clinical breast cancer. Int J Cancer. (Pred oncol.) 2000; 89: 209-212.
Speirs V, Parkers AT, Kerin MJ, Walton DS, Carleton PJ, Fox JN, et al. Coexpression of estrogen receptor alpha and beta: poor prognostic factors in human breast cancer? Cancer Res 1999; 59(3): 525-8.
Jarvinen TA, Pelto-Hiukko M, et al. Estrogen receptor beta is coexpressed with ER alpha and PR and associated with nodal status, grade, and proliferation rate in breast cancer. Am J Pathol 2000; 156: 29-35.
Omoto Y, Inoue S, Ogawa S, Toyama T, Yamashita H, Muramatsu M, et al. Clinical value of the wild-type estrogen receptor beta expression in breast cancer. Cancer Lett 2001; 163(2): 207- 212.
Mann S, Laucirica R, et al. Estrogen receptor beta expression in invasive breast cancer. Hum Pathol 2001; 32(1): 113-118.
Paech K, Webb P, Kuiper GGJM, Nilsson S, Gustafsson, Kushner PJ, et al. Differential ligand activation of estrogen receptors ER-a and ER-b at AP1 sites. Science 1997; 277: 1508-1510.
Powles TJ. Anti-estrogenic prevention of breast cancer –the make or break point. Nature Rev Cancer 2000; 2: 787-794.