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2009, Número 4

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Gac Med Mex 2009; 145 (4)


Principales mecanismos de evasión de la respuesta inmune por Mycobacterium tuberculosis

Chávez-Galán L, Arenas-Del Ángel MC, Sada-Ovalle I, Lascurain R

Idioma: Español
Referencias bibliográficas: 91
Paginas: 323-330
Archivo PDF: 157.44 Kb.


RESUMEN

En la actualidad, la tuberculosis pulmonar es considerada un problema grave de salud mundial. Para entender el proceso infeccioso de la tuberculosis es necesario conocer las interacciones entre la respuesta inmune del hospedero y su agente causal. Actualmente se han realizado grandes avances en la identificación de nuevas moléculas y genes que participan activamente en los mecanismos de evasión, generando la posibilidad de que en un futuro próximo se diseñen diversos compuestos químicos para el desarrollo de vacunas o terapias que tengan como blanco estas moléculas o genes. Sin embargo, no se han esclarecido completamente los diversos mecanismos con que cuenta la micobacteria para evadir la respuesta inmune del hospedero. En esta revisión se discute la evidencia experimental reciente sobre los mecanismos propuestos para el éxito de la bacteria.


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