Quesada AA, Bolaños CA

Idioma: Español
Referencias bibliográficas: 39
Paginas: 83-90
Archivo PDF: 256.00 Kb.

RESUMEN

La hiperhomocisteinemia se asocia a un aumento del riesgo de enfermedad vascular en estudios observacionales y en casos-controles. Elevaciones en la Homocisteína inducen cambios patológicos en la en la pared arterial, endotelio, stress oxidativo, inflamación y coagulación que llevan a aterosclerosis, manifestación común de eventos cerebrovasculares, cardiovasculares y vasculares periféricos. Debido a esto, se han hecho múltiples estudios dirigidos a determinar si la disminución de los niveles de Homocisteína plasmáticos con ácido fólico o vitaminas de complejo B pueden ser de utilidad para prevenir la enfermedad arterial coronaria. Aunque dichos estudios mostraron una disminución efectiva de la hiperhomocisteinemia, no lograron encontrar una reducción del riesgo cardiovascular lo que pone en duda si la hiperhomocisteinemia es un factor de riesgo, una consecuencia o un marcador de enfermedad cardiovascular.

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