medigraphic.com
Federación Mexicana de Ginecología y Obstetricia, A.C.

2012, Número 03

<< Anterior Siguiente >>

Ginecol Obstet Mex 2012; 80 (03)


Nuevas genovariantes del serovar L2 de Chlamydia trachomatis causantes de proctitis

Guerra-Infante FM, López-Hurtado M, Villagrana-Zesati R

Idioma: Español
Referencias bibliográficas: 57
Paginas: 208-217
Archivo PDF: 224.04 Kb.


RESUMEN

Los serotipos L1, L2 y L3 de Chlamydia trachomatis son la causa del linfogranuloma venéreo, que es un padecimiento crónico del sistema linfático y que es trasmitido sexualmente. Desde el año 2003 en Europa, Estados Unidos, Canadá y Australia ha habido brotes de infección por el serotipo L2 que origina proctitis, en lugar del linfogranuloma venéreo, en hombres que tienen sexo con hombres. Al parecer, estas cepas de L2 son una nueva genovariante (L2b) que da origen a padecimientos diferentes al linfogranuloma venéreo. Sin embargo, el análisis del genoma de L2b no difiere de manera importante del genoma de L2 (L2/434 UB) por lo que se ha considerado que la cepa L2b es una cepa clásica de L2. A pesar de lo anterior, nuevas genovariantes de L2 están apareciendo, mismas que no dan el linfogranuloma venéreo clásico o proctitis. Por esto es necesario analizar su genoma, para identificar los cambios genéticos ocurridos que hacen que estas cepas den lugar al linfogranuloma venéreo o proctitis.


REFERENCIAS (EN ESTE ARTÍCULO)

  1. Manavi K. A review on infection with Chlamydia trachomatis. Best Pract Res Clin Obstet Gyneacol 2006;20:941-951.

  2. Dirección General de Epidemiología. Boletín epidemiologia, semana 51, 2009 www.dgepi.salud.gob.mx

  3. Stary G, Stary A. Lymphogranuloma venereum outbreak in Europe. JDDG 2008;6:1-5.

  4. Kapoor S. Re-emergence of lymphogranuloma venereum. JEADV 2008;22:409-416.

  5. Williams D, Churchill D. Ulcerative proctitis in men who have sex with men: an emerging outbreak. BMJ 2006;14:99-100.

  6. Ward H, Martin I, Macdonald N, et al. Lymphogranuloma venereum in the United Kingdom. Clin Infect Dis 2007;44:26-32.

  7. Annan NT, Sullivan A, Nori A, Naydenova P, et al. Rectal Chlamydia -A reservoir of undiagnosed infection in MSM. Sex Transm Infect 2009;85:176-179.

  8. Aggarwal K, Jain VK, Gupta S. Bilateral groove sign with penoscrotal elephantiasis. Sex Transm Infect 2002;78:458.

  9. Kumaran MS, Gupta S, Ajith C, Kalra N, et al. Saxophone penis revisited. Int J STD AIDS 2006;17:65-66.

  10. Forrester B, Pawade J, Horner P. The potential role of serology in diagnosing chronic lymphogranuloma venereum (LGV): a case of LGV mimicking Crohn’s disease. Sex Transm Infect 2006;82:139-140.

  11. Ndinya-Achola JO, Kihara AN, Fisher LD, Krone MR, et al. Presumptive specific clinical diagnosis of genital ulcer disease (GUD) in a primary health care setting in Nairobi. Int J STD AIDS 1996;7:201-205.

  12. Osoba AO. Lymphogranuloma venereum in women. Arch AIDS Res 1994;8:221-234.

  13. Onile BA, Tolu O. Genital ulcer disease in Ilorin, Nigeria. Afri J Clin Exper Microbiol 2002;3:21-23.

  14. Ahdoot A, Kotler DP, Suh JS, Kutler C, Flamholz R. Lymphogranuloma venereum in human immunodeficiency virusinfected individual in New York City. J Clin Gastroenterol 2006;40:385-390.

  15. Nieuwenhuis RF, Ossewaarde JM, Gotz HM, Dees J, et al. Resurgence of lymphogranuloma venereum in Western Europe: an outbreak of Chlamydia trachomatis serovar L2 proctitis in the Netherlands among men who have sex with men. Clin Infect Dis 2004;39:996-1003.

  16. Nieuwenhuis RF, Ossewaarde JM, van der Meijden WI, Neumann HA. Unusual presentation of early lymphogranuloma venereum in an HIV-1 infected patient: effective treatment with 1 g azithromycin. Sex Transm Infect 2003;79:453-455.

  17. Kropp RY, Wong T, Canadian LGV Working Group. Emergence lymphogranuloma venereum in Canada. CMAJ 2005;172:1674-1676.

  18. Bremer V, Meyer T, Marcus U, Hamouda O. Lymphogranuloma venereum emerging in men who have sex with men in Germany. Eur Surveill 2006;11:152-154.

  19. Spaargaren J, Fennema HS, Morré SA, de Vries HJ, Coutinho RA. New lymphogranuloma venereum Chlamydia trachomatis variant, Amsterdam. Emerg Infect Dis 2005;11:1090-1092.

  20. Christerson L, de Vries HJ, de Barbeyrac B, Gaydos CA, et al. Typing of lymphogranuloma venereum Chlamydia trachomatis strains. Emerg Infect Dis 2010;16:1777-1779.

  21. van de Laar MJ, Koedijk FD, Gotz HM, de Vries HJ. A slow epidemic of LGV in the Netherlands in 2004 and 2005. Euro Surveill 2006;11:150-152.

  22. Simms I, Ward H, Martin I, Alexander S, Ison C. Lymphogranuloma venereum in Australia. Sex Health 2006;3:131-133.

  23. Götz HM, Ossewaarde JM, Nieuwenhuis RF, van der Meijden WI, et al. A cluster of lymphogranuloma venereum among homosexual men in Rotterdam with implications for other countries in Western Europe. Ned Tijdschr Geneeskd 2004;148:441-442.

  24. Savage EJ, van de Laar MJ, Gallay A, van der Sande M, et al, and European Surveillance of Sexually Transmitted Infections (ESSTI) network. Lymphogranuloma venereum in Europe, 2003-2008. Euro Surveill 2009;14:1-5.

  25. Ward H, Alexander S, Carder C, Dean G, et al. The prevalence of lymphogranuloma venereum infection in men who have sex with men: results of a multicentre case finding study. Sex Transm Infect 2009;85:173-175.

  26. Herida M, de Barbeyrac B, Sednaoui P, Scieux C, et al. Rectal lymphogranuloma venereum surveillance in France 2004-2005. Euro Surveill 2006;11:1-3.

  27. López-Hurtado M, Guerra-Infante FM. Papel de los anticuerpos en el desarrollo de la infección por Chlamydia trachomatis y su utilidad en el diagnóstico. Perinatol Reprod Hum 2002;16:140-150.

  28. Macdonald N, Ison C, Martin I, Alexander S, et al. Initial results of enhanced surveillance for lymphogranuloma venereum (LGV) in England. Euro Surveill 2005;10. Disponible en línea: http://www.eurosurveillance.org/ViewArticle.aspx?ArticleId=2629

  29. Spaargaren J, Schachter J, Moncada J, de Vries HJ, et al. Slow epidemic of lymphogranuloma venereum L2b strain. Emerg Infect Dis 2005;11:1787-1788.

  30. Stark D, van Hal S, Hillman R, Harkness J, Marriott D. Lymphogranuloma venereum in Australia: Anorectal Chlamydia trachomatis serovar L2b in men who have sex with men. J Clin Microbiol 2007;45:1029-1031.

  31. Halse TA, Musser KA, Limberger RJ. A multiplexed real-time PCR assay for rapid detection of Chlamydia trachomatis and identification of serovar L-2, the major cause of lymphogranuloma venereum in New York. Mol Cell Probes 2006;20:290-297.

  32. Stary G, Meyer T, Bangert C, Kohrgruber N, et al. New Chlamydia trachomatis L2 strains identified in a recent outbreak lymphogranuloma venereum in Vienna, Austria. Sex Transm Dis 2008;35:377-382.

  33. Gomes JP, Nunes A, Florindo C, Ferreira MA, et al. Lymphogranuloma venereum in Portugal. Sex Transm Dis 2009;36:88-91.

  34. de Haro-Cruz MJ, Deleón-Rodríguez I, Escobedo-Guerra MR, López-Hurtado M, et al. Genotyping of Chlamydia trachomatis from endocervical specimens of infertile Mexican women. Enferm Infecc Microbiol Clin 2011;29:102-108.

  35. Thomson NR, Holden MT, Carder C, Lennard N, et al. Chlamydia trachomatis: Genome sequence analysis of lymphogranuloma venereum isolates. Genome Res 2008;18:161-171.

  36. Comanducci M, Ricci S, Ratti G. The structure of a plasmid of Chlamydia trachomatis believed to be required for growth with mammalian cells. Mol Microbiol 1988;2:531-538.

  37. Read TD, Brunham RC, Shen C, Gill SR, et al. Genome sequence of Chlamydia trachomatis MoPn and Chlamydia pneumoniae AR39. Nucleic Acids Res 2000;28:1397-1406.

  38. Read TD, Myers GS, Brunham RC, Nelson WC, et al. Genome sequence of Chlamydia caviae (Chlamydia psittaci GPIC): examining the role of niche-specific genes in the evolution of the Chlamydiaceae. Nucleic Acids Res 2003;31:2134-2147.

  39. Belland RJ, Scidmore MA, Crane DD, Hogan DM, et al. Chlamydia trachomatis cytotoxicity associated with complete and partial cytotoxin genes. Proc Natl Acad Sci 2001;98:13984-13989.

  40. Carlson JH, Hughes S, Hogan D, Cieplak G,. Polymorphisms in the Chlamydia trachomatis cytotoxin locus associated with ocular and genital isolates. Infect Immun 2004;72:7063-7072.

  41. Nelson DE, Crane DD, Taylor LD, Dorward DW, et al. Inhibition of Chlamydiae by primary alcohols correlates with the strain-specific complement of plasticity zone phospholipase D genes. Infect Immun 2006;74:73-80.

  42. Guest JR, Roberts RE. Cloning, mapping, and expression of the fumarase gene of Escherichia coli K-12. J Bacteriol 1983;153:588-596.

  43. Guest JR, Miles JS, Roberts RE, Woods SA. The fumarase genes of Escherichia coli: Location of the fumB gene and discovery of a new gene (fumC). J Gen Microbiol 1985;131:2971-2984.

  44. Shaw AC, Gevaert K, Demol H, Hoorelbeke B, et al. Comparative proteome analysis of Chlamydia trachomatis serovar A, D and L2. Proteomics 2002;2:164-186.

  45. Cunningham L, Guest JR. Transcription and transcript processing in the sdhCDAB-sucABCD operon of Escherichia coli. Microbiology 1998;144:2113-2123.

  46. Graham DE, Xu H, White RH. Methanococcus jannaschii uses a pyruvoyl-dependent arginine decarboxylase in polyamine biosynthesis. J Biol Chem 2002;277:23500-23507.

  47. Giles TN, Fisher DJ, Graham DE. Independent inactivation of arginine decarboxylase genes by nosense and missense mutations led to pseudogene formation in Chlamydia trachomatis serovar L2 and D strains. BMC Evol Biol 2009;9:166-198.

  48. Auguet M, Viossat I, Marin JG, Chabrier PE. Selective inhibition of inducible nitric oxide synthase by agmatine. Jpn J Pharmacol 1995;69:285-287.

  49. Delcher AL, Kasif S, Fleischmann RD, Peterson J, et al. Alignment of whole genomes. Nucleic Acids Res 1999;27:2369-2376.

  50. Jewett TJ, Fischer ER, Mead DJ, Hackstadt T. Chlamydial TARP is a bacterial nucleator of actin. Proc Natl Acad Sci 2006;03:15599-15604.

  51. Carlson JH, Porcella SF, McClarty G, Caldwell HD. Comparative genomic analysis of Chlamydia trachomatis oculotropic and genitotropic strains. Infect Immun 2005;73:6407-6418.

  52. Gomes JP, Bruno WJ, Nunes A, Santos N, et al. Evolution of Chlamydia trachomatis diversity occurs by widespread interstrain recombination involving hotspots. Genome Res 2007;17:50-60.

  53. McClarty G. Chlamydial metabolism as inferred from the complete genome sequence. In: Chlamydia: Intracellular biology, pathogenesis, and immunity. New York: Wiley, 1999; 69-100.

  54. Kubo A, Stephens RS. Sustrate-specific diffusion of select dicarboxylates through Chlamydia trachomatis PorB. Microbiology 2001;147:3135-3140.

  55. Lara-Núñez A, Rodríguez-Sotres R. Plástidos no fotosintéticos: su papel metabólico y los intercambiadores de su membrana interna. REB 2003;22:130-137.

  56. Dautry-Varsat A, Subtil A, Hackstadt T. Recent insights into the mechanisms of Chlamydia entry. Cell Microbiol 2005;7:1714–1722.

  57. Fehlner-Gardiner C, Roshick C, Carlson JH, Hughes S, et al. Molecular basis defining human Chlamydia trachomatis tissue tropism. A possible role for tryptophan synthase. J Biol Chem 2002;277:2893-2903.




2020     |     www.medigraphic.com