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2007, Número 6

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Rev Med Inst Mex Seguro Soc 2007; 45 (6)


Implicaciones del sistema renina-angiotensina en la nefropatía diabética

Ortega-Pierres LE, Higareda-Mendoza AE, Pardo-Galván MA, Beltrán-Peña E, Gómez-García A, Farías-Rodríguez VM, Álvarez-Aguilar C

Idioma: Español
Referencias bibliográficas: 71
Paginas: 601-610
Archivo PDF: 171.87 Kb.


RESUMEN

En las últimas décadas, la diabetes mellitus tipo 2 ha tenido un alarmante incremento en su incidencia en el mundo y México, especialmente en la población mexicoamericana. La etiología de la diabetes mellitus tipo 2 es múltiple, con una interacción compleja entre factores de riesgo ambientales y genéticos. El riñón es un órgano blanco que se daña en la diabetes mellitus tipo 2. La predisposición genética para la enfermedad renal en el paciente con diabetes mellitus tipo 2 parece ser el resultado del efecto final acumulativo de múltiples factores. Los componentes del sistema renina-angiotensina y los polimorfismos en sus genes son un área de intensa investigación de asociación para la enfermedad renal. La identificación temprana de factores genéticos de riesgo para el desarrollo de la enfermedad renal podría favorecer el tratamiento oportuno y tener influencia en la respuesta al tratamiento con medicamentos y dieta.


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