García RJC, Izu BRM, Amutio DE

Idioma: Español
Referencias bibliográficas: 47
Paginas: 69-79
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RESUMEN

No existe actualmente ningún tratamiento curativo de los linfomas cutáneos en estadios avanzados. Históricamente estos pacientes han sido sometidos a esquemas de quimioterapia utilizados en linfomas sistémicos generalmente muy tóxicos, y de beneficios muy limitados. Gracias al creciente conocimiento de la etiopatogenia de los linfomas cutáneos se han podido identificar dianas terapéuticas y desarrollar nuevas moléculas que se están probando en la actualidad con resultados esperanzadores. Este el caso de los inhibidores de las histonas desacetilasas (IHDAC) y los nuevos anticuerpos monoclonales, entre otros. De la misma forma ha podido observarse que fármacos útiles en otros tumores, como gemcitabina, bortezomib o doxorubicina liposomal, también son activos en los LCP-T, al menos, en estudios preliminares. En los últimos años se están añadiendo a nuestro arsenal nuevos medicamentos y estrategias terapéuticas encaminadas a cambiar la historia natural de esta enfermedad. En este artículo revisamos los avances terapéuticos en este campo.

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