Aguirre GJ

Idioma: Español
Referencias bibliográficas: 19
Paginas: 40-45
Archivo PDF: 248.58 Kb.

FRAGMENTO

En 1911 el Dr. Frank Burr Mallory, patólogo del Boston City Hospital, publicó en el boletín del Hospital Johns Hopkins un artículo titulado “Cirrosis del hígado. Cinco tipos de lesiones de las cuales puede originarse” (figura 1), en el que describió las cirrosis tóxica, infecciosa, pigmentaria, sifilítica y alcohólica. En los hepatocitos de pacientes con cirrosis alcohólica observó inclusiones citoplásmicas hialinas que se teñían intensamente con eosina y hematoxilina fosfotúngstica; los hepatocitos eran rodeados y destruidos por leucocitos polimorfonucleares1 (figura 2). Las inclusiones recibieron el nombre de “cuerpos de Mallory” (CM), “hialino-alcohólico” o “hialino de Mallory”.

REFERENCIAS (EN ESTE ARTÍCULO)

1. Mallory FB. Cirrosis of the liver. Five different types of lesions from which it may arise. Bul Johns Hopkins Hosp. 1911;22:69-75.

2. Reuben A. Pearls of pathology. Hepatology. 2003;37:715-8.

3. Freeman W. Frank Burr Mallory. A doctor of physicians. N Engl J Med. 1944;231:824-8.

4. Scully RE, Vickery AL Jr. Surgical pathology at the hospitals of Harvard Medical School. En: Guiding the Surgeon’s Hand. The History of American Surgical Pathology. Ed. Rosai J. Chap 6. American Registry of Pathology. Armed Forces Institute of Pathology. Washington, D.C.; 1997. p. 91-3.

5. Jensen K, Gluud C. The Mallory body: morphological, clinical and experimental studies (Part 1 of a literature survey). Hepatology. 1994;20:1061-77.

6. Rubin E, Lieber CS. Experimental alcoholic hepatitis: a new primate model. Science. 1973;182:712-3.

7. Wiggers KD, French SW, French BA, Carr BN. The ultrastructure of Mallory body filaments. Lab Invest. 1973;29:652-8.

8. Denk H, Gschnait F, Wolff K. Hepatocellular hyaline (Mallory bodies) in long term griseofulvin-treated mice: a new experimental model for the study of hyaline formation. Lab Invest. 1975;32:773-6.

9. Zatloukal K, French SW, Stumptner C, Strnad P, Harada M, Toivola DM, et al. From Mallory to Mallory-Denk bodies: what, how and why ? Exp Cell Res. 2007;313:2033-49.

10. Denk H, Eckerstorfer R. Colchicine-induced Mallory bodies formation in the mouse. Lab Invest. 1977;36:563-5.

11. Yokoo H, Harwood TR, Racker D, Arak S. Experimental production of Mallory bodies in mice by diet containing 3,5-diethoxycarbonil-1,4-dihydrocollidine. Gastroenterology. 1982;83:109-13.

12. Meierhenry EF, Ruebner BH, Gershwin ME, Hsie LS, French SW. Mallory body formation in hepatic nodules of mice ingesting dieldrin. Lab Invest. 1981;44:392-6.

13. Franke WW, Denk H, Schmid E, Osborn M, Weber K. Ultrastructural, biochemical, and immunologic characterization of Mallory bodies in livers of griseofulvin-treated mice. Fimbriated rods of filaments containing prekeratinlike polypeptides. Lab Invest. 1979;40:207-20.

14. Macario AJL, Conway de Macario E. Sick chaperones, cellular stress and disease. N Engl J Med. 2005;353:1489-501.

15. Goldberg AL. Protein degradation and protection against misfolded or damaged proteins. Nature. 2003;426:895-9.

16. Stumptner C, Fuchsbichler A, Heid H, Zatloukal K, Denk H. Mallory body -a disease- associated type of sequestosome. Hepatology. 2002;35:1053-62.

17. Omary MB, Ku N-O, Strnad P, Hanada S. Toward unraveling the complexity os simple epithelials keratins in human disease. Lab Invest. 2009;119:1794-805.

18. Fataccioli V, Andraud E, Gentil M, French SW, Rouach H. Effects of chronic ethanol administration on rat proteasome activities: relationship with oxidative stress. Hepatology. 1999;29:14-20.

19. Harada M, Hanada S, Toivola DM, Ghori N, Omary MB. Autophagy activation by rapamycin eliminates mouse Mallory- Denk bodies and blocks their proteasome inhibitormediated formation. Hepatology. 2088;47:2026-35.