2000, Número 2
<< Anterior
Rev Endocrinol Nutr 2000; 8 (2)
Fisiopatología de la osteoporosis posmenopáusica
Arzac PJP
Idioma: Español
Referencias bibliográficas: 17
Paginas: 73-76
Archivo PDF: 129.65 Kb.
RESUMEN
La fisiopatología de la osteoporosis posmenopáusica es un problema complejo que presenta un reto a la medicina moderna, al igual que otras patologías multifactoriales complejas, por la gran variedad de elementos que intervienen en ellas, algunas de ellas ya conocidas y otras muchas por descubrir. Hasta el momento la investigación se ha orientado hacia los factores genéticos, la ingesta de calcio, estrógenos, prostaglandinas, citocinas, factores de crecimiento
similares a la insulina, óxido nítrico y otras.
REFERENCIAS (EN ESTE ARTÍCULO)
Tobias JH, Cook DG, Chambers TJ, Dalzell N. A comparison of bone mineral density between Caucasian, Asian and Afro-Caribbean women. Clinical Science 1994; 87:587-591.
Barthe N, Basse-Cathalinat B, Meunier PJ, Ribot C et al. Measurement of bone mineral density in Mother-Daughter pairs for evaluating the family influence on bone mass acquisition: A GRIO Survey. Osteoporos Int 1998; 8: 379-384.
Deng HW, Chen WM, Recker S et al. Direct evidence of genetic determination of osteoporotic fractures. J Bone Miner Res 1999; Suppl 1: 1171.
Seeman E, Hooper JL, Young NR et al. Do genetic factors contribute to associations between muscle strength, fatfree mass and bone density? A twin study. Am J Physiol 1996; 270: E320-7.
Nordin BEC. Osteomalacia, osteoporosis, and calcium deficiency. Clin Orthop 1960; 17: 235-58.
Morris HA, Need AG, Horowitz M et al. Calcium absorption in normal and osteoporotic postmenopausal women. Calcif Tissue Int 1991; 49: 240-3.
Morris HA, Need AG, Horowitz M et al. Calcium absorption in normal and osteoporotic postmenopausal bone. Calcif Tissue Int 1991; 49: 240-3.
Allbright F, Reifestein S Jr. Posmenopausal osteoporosis. JAMA 1941; 116: 2465-2468.
Suda T, Miyaura C. Patogenesis of bone loss due to estrogen deficiency. Osteoporos Int 1997; (Suppl. 3): S43-S46.
Pacifici R. Review. Estrogen, cytokines, and pathogenesis of postmenopausal osteoporosis. J Bone Miner Res 1996; 11: 1043-51.
Takahashi N, Udagawa N, Akatsu T et al. Role of colony stimulating factors in osteoclast development. J Bone Miner Res 1991; 6: 977-85.
Chenu C, Pfeilschifter J, Mundy GR, Roodman GD. Transforming growth factor B inhibits formation of osteoclast-like cells in long term human bone marrow cultures. Proc Natl Acad Sci USA 1988; 85: 5683-7.
Teitelbaum SL, Tanaka H, Mimura M et al. Integrins and osteoclast polarization. Osteoporos Int 1997; (Suppl. 3): S54-S56.
Sunil JW. Effects of nitric oxide donor, nitroglicerin, on prevention of osteoporosis in humans. A clinical study. J Bone Miner Res 1999; Suppl 1: SA389.
Rosen CJ, Donahue LR. Insuline growth factors: Potential therapeutic options for osteoporosis. Trends Endocrin Metab 1995; 6: 235-240.
Schussheim DH, Kulak CAM, Kurland E et al. Decreased serum insulin-like growth factor-1 levels are associated with low bone mass in young women. J Bone Miner Res 1999; Suppl 1, SA328.
Garnero P, Sornay-Rendu E, Delmas PD. Low serum IGF-1, but not IGF BP3, is a strong predictor of osteoporotic fractures. J Bone Miner Res 1999; Suppl: T267.