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2011, Número 4

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Rev Fac Med UNAM 2011; 54 (4)


Fertilidad masculina modulada por melatonina

Velázquez PM, Gutiérrez-Ruiz J, Prieto-Gómez B

Idioma: Español
Referencias bibliográficas: 49
Paginas: 24-33
Archivo PDF: 222.27 Kb.


RESUMEN

La melatonina en algunos países se usa desde hace mucho tiempo para reducir los síntomas de algunas enfermedades neuropsiquiátricas infantiles. En adultos se toma primordialmente para combatir problemas de trastornos del sueño. Por sus propiedades antioxidantes también ha sido utilizada como coadyuvante para contrarrestar algunos tipos de cáncer. Esta hormona es usada en cremas y bloqueadores solares para la piel que prometen el antienvejecimiento celular. Los efectos secundarios producidos por el uso prologado de la melatonina no están del todo claros. Con el propósito de conocer si el uso crónico de esta hormona altera la reproducción y los eventos que a ésta subyacen (como lo es la fertilidad), se propuso revisar la influencia que tiene sobre el eje reproductor de mamíferos masculinos, incluyendo al ser humano.


REFERENCIAS (EN ESTE ARTÍCULO)

  1. Tam CW, Chan KW, Liu VW, Pang B, Yao KM, Shiu SY. Melatonin as a negative mutagenic hormonal regulator of human prostate epithelial cell growth: potential mechanisms and clinical significance. J Pineal Res. 2008;45:403-12.

  2. Girgert R, Hanf V, Emons G, Gründker C. Membrane-bound melatonin receptor MT1 down-regulates estrogen responsive genes in breast cancer cells. J Pineal Res. 2009;47:23-31.

  3. Korkmaz A, Reiter RJ, Topal T, Manchester LC, Oter S, Tan DX. Melatonin: An Established Antioxidant Worthy of Use in Clinical Trials. Mol Med. 2009;15:43-50.

  4. Reyes-Prieto BM, Velázquez-Paniagua M, Prieto-Gómez B. Melatonina y Neuropatologias. Revista de la Facultad de Medicina. 2009;52:105-9.

  5. Cardinali DP. Melatonin. Physiology and clinical applications. Vertex. 2007;18:288-93.

  6. Bueno AV, Bernardino OS, Mendoza FJ. Melatonin, Sleep, and Sleep Disorders. Sleep Med Clin. 2007;2:303-31.

  7. Guerrero MJ, Carrillo-Vico A, y Lardone JP. La melatonina. Investigación y Ciencia. 2007;30-8.

  8. Kobayashi H, Kromminga A, Dunlop TW, Tychsen B, Conrad F, Suzuki N, Memezawa A, Bettermann A, Aiba S, Carlberg C, Paus R A role of melatonin in neuroectodermalmesodermal interactions: the hair follicle synthesizes melatonin and expresses functional melatonin receptors. FASEB J. 2005;19:1710-2.

  9. Hardeland R. Melatonin, hormone of darkness and more: occurrence, control mechanisms, actions and bioactive metabolites. Cell Mol Life Sci. 2008 ;65:2001-18.

  10. Pandi-Perumal SR, Trakht I, Srinivasan V, Spence DW, Maestroni GJ, Zisapel N, Cardinali DP. Physiological effects of melatonin: role of melatonin receptors and signal transduction pathways. Prog Neurobiol. 2008;85:335-53.

  11. Tam CW, Chan KW, Liu VW, Pang B, Yao KM, Shiu SY. Melatonin as a negative mitogenic hormonal regulator of human prostate epithelial cell growth: potential mechanisms and clinical significance. J Pineal Res. 2008;45:403-12.

  12. Shiu SY, Li L, Siu SW, Xi SC, Fong SW, Pang SF. Biological Basis and Possible Physiological Implications of Melatonin Receptor- Mediated Signaling in the Rat Epididymis. Biol Signals Recept. 2000;9:172-87.

  13. Velázquez Paniagua M. Modulación de la excitabilidad del hipotálamo anterior por la administración de melatonina en la rata. 2001; Facultad de Ciencias-UNAM. (tesis de maestría).

  14. Revel FG, Ansel L, Klosen P, Saboureau M, Pévet P, Mikkelsen JD, Simonneaux V. Kisspeptin: a key link to seasonal breeding. Rev Endocr Metab Disord. 2007;8:57-65.

  15. Dungan HM, Clifton DK, Steiner RA. Minireview: kisspeptin neurons as central processors in the regulation of gona-dotropin-releasing hormone secretion. Endocrinology. 2006; 147:1154-8.

  16. Frungieri MB, Mayerhofer A, Zitta K, Pignataro OP, Calandra RS, Gonzalez-Calvar SI. Direct effect of melatonin on Syrian hamster testes: melatonin subtype 1a receptors, inhibition of androgen production, and interaction with the local corticotropin-releasing hormone system. Endocrinology. 2005;146:1541-52.

  17. Gutiérrez-Ruiz J, Granados-Canseco F, Martínez-Esparza C, Velázquez-Paniagua M, Prieto-Gómez. Chronic melatonin application modifies the cytoarchitecture of testis and decreases the sperm number in Wistar rat. Pharmacologyonline. 2006;3:422-7.

  18. Yilmaz B, Kutlu S, Mogulkoç R, Canpolat S, Sandal S, Tarakçi B, Kelestimur H. Melatonin inhibits testosterone secretion by acting at hypothalamo-pituitary-gonaldal axis in the rat. Neuro Endocrinol Lett. 2000;21:301-6.

  19. Gilad E, Laudon M, Matzkin H, Zisapel N. Evidence for a local action of melatonin on the rat prostate. J. Urol. 1998; 159:1069-73.

  20. Fujinoki M. Melatonin-enhanced hyperactivation of hamster sperm. Reproduction. 2008;136:533-41.

  21. Sliwa L, Stochmal E. The effect of melatonin on directional motility of human sperm under in vitro conditions. Folia Med Cracov. 2001;42:123-8.

  22. Tanyildizi S, Bozkurt T, Sakün OF. In Vitro Effects of Melatonin on Hyaluronidase Activity and Sperm Motility in Bull Semen. Turk J Vet Anim Sci. 2006;30:89-93.

  23. Gwayi N, Bernard RTF. The effects of melatonin on sperm motility in vitro in Wistar rats. Andrologia. 2002;34:391-6.

  24. Ishii H, Tanaka N, Kobayashi M, Kato M, Sakuma Y. Gene structures, biochemical characterization and distribution of rat melatonin receptors. J Physiol Sci. 2009; 59:37-47.

  25. Andersen ML, Tufik S. Does male sexual behavior require progesterone? Brain Research Reviews. 2006:51; 136-143.

  26. Morgan PJ, Hazlerigg DG. Photoperiodic signalling through the melatonin receptor turns full circle. J Neuroendocrinol. 2008;20:820-6.

  27. Arendt J, Skene DJ. Melatonin as a chronobiotic. Sleep Med Re. 2005;9:25-39.

  28. Hiebert SM, Green SA, Yellon SM. Daily timed melatonin feedings mimic effects of short days on testis regression and cortisol in circulation in Siberian hamsters. General and Comparative Endocrinology. 2006;146:211-6.

  29. Silman RE. Melatonin: a contraceptive for the nineties. Eur J Obstet Gynecol Reprod Biol.1993;49:3-9.

  30. Tanja G, Aurich JE. Regulation of seasonal reproductive activity in the stallion, ram and hamster. Anim Reprod Sci. 2000;58:197-213.

  31. Reiter RJ, Tan DX, Manchester LC, Paredes SD, Mayo JC, Sainz RM. Melatonin and Reproduction Revisited. Biol Reprod. 2009; 81:445-56.

  32. Olcese J. The mammalian pineal gland and reproduction. Controversies and strategies for future research. Adv Exp med Biol. 1995;377:1-14.

  33. Macchi MM, Bruce JN. Human pineal physiology and functional significance of melatonin. Front Neuroendocrinol. 2004; 3-4:177-95.

  34. Boczek-Leszczyk E, Juszczak M. The influence of melatonin on human reproduction Pol Merkur Lekarski. 2007; 134:128-30.

  35. Luboshitzky R, Shen-Orr Z, Nave R, Lavi S, Lavie P. Melatonin administration alters semen quality in healthy men. J Androl. 2002;4:572-8.

  36. Drago F, Busà L, Benelli A, Bertolini A. Acute low doses of melatonin stimulate rat sex behavior: the role of serotonin neurotransmission. Eur J Pharmacol.1999;385: 1-6

  37. Pandi-Perumal SR, Srinivasan V, Maestroni GJ, Cardinali DP, Poeggeler B, Hardeland R. Melatonin Nature’s most versatile biological signal? The FEBS Journal. 2006;273:2813-38.

  38. http://www.sexovida.com/clinica/melatonina.htm

  39. Brotto LA, Gorzalka BB. Melatonin enhances sexual behavior in the male rat. Physiol Behav. 2000;68:483-6.

  40. d’Istria M, Serino I, Izzo G, Ferrara D, De Rienzo G, Minucci S. Effects of melatonin treatment on leydig cells in the testis of the frog rana sculenta. 2004;12:293-9.

  41. Haro CJ, Martínez A, Canchola ME .Evidencia del efecto afrodisiaco de las beta carbolinas análogos de la melatonina. Arch Mex Anat. 2007;2;9-13.

  42. Yamada K, Maruyama K, Mogami S, Miyagawa N, Tsuboi M. Influence of melatonin on reproductive behavior in male rats. Pharm Bull. 1992;40:2222-3.

  43. 43.Wirojanan J, Jacquemont S, Diaz R, Bacalman S, Anders TF, Hagerman RJ, Goodlin-Jones BL. The efficacy of melatonin for sleep problems in children with autism, fragile X syndrome, or autism and fragile X syndrome. J Clin Sleep Med. 2009;15:145-50.

  44. 44.Gupta M, Aneja S, Kohli K. Add-on melatonin improves sleep behavior in children with epilepsy: randomized, double-blind, placebo-controlled trial. J Child Neurol. 2005; 20:112-5.

  45. Martinez D, Lenz SCM. Circadian rhythm sleep disorders. Indian J Med Res. 2010;131:141-9.

  46. Srinivasan V, Spence DW, Pandi-Perumal SR, Trakht I, Cardinali DP. Therapeutic actions of melatonin in cancer: possible mechanisms. Integr Cancer Ther. 2008;7(3):189-203.

  47. Srinivasan V, Pandi-Perumal SR, Cardinali DP, Poeggeler B, Hardeland R. Melatonin in Alzheimer’s disease and other neurodegenerative disorders. Behav Brain Funct. 2006;4:2-15.

  48. 48.Mayo JC, Sainz RM, Tan DX, Antolín I, Rodríguez C, Reiter RJ. Melatonin and Parkinson’s disease. Endocrine. 2005; 27:169-78.

  49. Srinivasan V, Spence DW, Pandi-Perumal SR, Trakht I, Cardinali DP. Jet lag: therapeutic use of melatonin and possible application of melatonin analogs. Travel Med Infect Dis. 2008; 6:17-28.




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