Salazar-Exaire JD, Reyes-Martínez RI, González-Álvarez R, Briones-Garduño JC

Idioma: Español
Referencias bibliográficas: 26
Paginas: 121-124
Archivo PDF: 41.59 Kb.

RESUMEN

Introducción: la preeclampsia tiene una incidencia de aproximadamente 5% en la población obstétrica. La fisiopatología de esta entidad tiene como característica fundamental la disfunción endotelial y la activación plaquetaria. Las selectinas son moléculas que regulan la interacción de éstas. La P-selectina se expresa en la superficie de la plaqueta. El objetivo es describir el papel de la P-selectina en la reactividad endotelial en pacientes con preeclampsia y compararlo con pacientes con embarazo normal. Material y métodos: estudio de casos y controles. Fueron seleccionadas 30 pacientes con preeclampsia severa (casos) que recibieron atención en la Unidad de Cuidados Intensivos y se contrastaron con 30 pacientes con embarazo sin patología concomitante (controles), de la Unidad de Tococirugía del mismo hospital. A todas las mujeres, previo consentimiento informado, se les tomaron 10 ml de sangre periférica y se determinó la P-selectina mediante la técnica ELISA, con un kit Bender Med. Resultados: se compararon las principales variables clínicas, bioquímicas y hematológicas, resaltando la diferencia significativa respecto a P-selectina. Conclusiones: la P-selectina es un marcador de la reactividad endotelial en pacientes con preeclampsia severa.

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