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2008, Número S2

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Rev Med UV 2008; 8 (S2)


Usando neurotoxinas para entender el circuito cerebral que regula el ciclo vigilia-sueño

Blanco CCA, Shiromani PJ

Idioma: Español
Referencias bibliográficas: 56
Paginas: 24-36
Archivo PDF: 913.16 Kb.


RESUMEN

Una de las más importantes metas de una disciplina científicaes elaborar modelos que expliquen los fenómenos que se están estudiando. Así, para el caso de la neurofisiología del sueño y la vigilia, hay varios modelos bien establecidos que intentan explicar cómo está constituida, así como la forma en que opera la red neuronal que regula estos fenómenos. Por otro lado, los modelos no sólo explican cómo los fenómenos ocurren; sino además; de ellos se pueden derivar predicciones basadas en su lógica interna. Basados en estas predicciones, los modelos se ponen a prueba constantemente y así se constata su veracidad. En este capítulo se abordará algunos ejemplos de cómo en nuestro laboratorio hemos usado neurotoxinas para probar directamente varias hipótesis en donde se propone que ciertos grupos de neuronas regularían los estados de vigilancia. El propósito de usar neurotoxinas es destruir estas neuronas para luego observar los efectos de estas lesiones sobre el sueño y la vigilia. Así, se revisarán las lesiones de las neuronas noradrenérgicas del locus coeruleus, de las histaminérgicas de núcleo tuberomamilar, de las neuronas colinérgicas del cerebro basal anterior, así como finalmente se relatará los efectos sobre los estados de vigilancia de las lesiones múltiples de estos mismos grupos neuronales. Cada parte fue tratada brevemente y se dejaron los detalles metodológicos para ser consultados en las referencias respectivas.


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