Hernández-Suárez G, Ortiz N, González M, Muñoz N

Idioma: Ingles.
Referencias bibliográficas: 33
Paginas: 486-492
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RESUMEN

Objetivo. Evaluar el riesgo a corto plazo de neoplasia intraepitelial cervical de alto grado (CIN2/CIN3+) en mujeres con citología cervicouterina normal e infección por virus del papiloma humano de alto riesgo (HR-HPV). Material y métodos. Cohorte prospectiva de 2 200 mujeres evaluadas cada seis meses durante 9 años en promedio. En cada visita se tomó muestra cervical para extendido y detección de HPV DNA. El riesgo absoluto de CIN2/CIN3+ a la siguiente visita fue calculado utilizando el método de Kaplan-Meier. Resultados. En mujeres con citología normal e infección concomitante por HR-HPV el riesgo absoluto de presentar CIN2/CIN3+ fue de 1.06% (95%CI, 0.57-2.20). Este riesgo fue cinco veces mayor al observado en todas las mujeres con citología normal (0.20%; 95%CI, 0.12-0.32) pero siete veces menor que el observado en mujeres con lesiones intraepiteliales escamosas de bajo grado con infección concomitante (7.24%; 95%CI, 3.78-15.2). Conclusión. El riesgo absoluto de CIN2/3+ a corto plazo luego de una citología normal e infección por HR-HPV es baja (~1%), sugiriendo que, a corto plazo, la prueba de HR-HPV tiene utilidad clínica muy limitada en mujeres con citología normal.

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