2010, Número 6
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Bol Med Hosp Infant Mex 2010; 67 (6)
Resultados de tratamiento para cáncer infantil en una población de recursos limitados en Bogotá, Colombia
Buendía-Hernández A, Loboguerrero-Compagnoli J, Lozano-León JM
Idioma: Español
Referencias bibliográficas: 47
Paginas: 518-535
Archivo PDF: 414.33 Kb.
RESUMEN
Introducción. A pesar de los notables progresos en cáncer infantil, más del 60% de los niños afectados en el mundo tienen escaso acceso a tratamientos eficaces. El propósito de este estudio fue evaluar los resultados de tratamiento en una situación de recursos limitados.
Métodos. Fue un estudio descriptivo-histórico con componente analítico en 242 menores de 16 años atendidos entre 1990 y 2007 en la
Clínica Infantil Colsubsidio de Bogotá, Colombia. Durante tres periodos se introdujeron protocolos internacionales, atención en “hospital de día” para tratamientos de quimioterapia y soporte ambulatorio, con enfermeras entrenadas en oncología, una pediatra oncóloga y un hematólogo con dedicación de 8 horas, el apoyo en hospitalización de médicos pediatras 24 horas y la agilización de trámites administrativos. Se compararon la supervivencia y las fallas de tratamiento.
Resultados. Se observó aumento (40.5 a 63%) en la supervivencia (
P =0.021) y disminución (22.4 a 8.9%) en la remisión a otros centros (
P =0.025); tendencia a la reducción en mortalidad por complicaciones agudas (16.3 a 9.9%) y en frecuencia de rechazo o abandono del tratamiento (5.2 a 3%). La supervivencia libre de eventos para leucemia linfoblástica fue de 65% a 10 años.
Conclusiones. El programa mostró resultados alentadores en un contexto de recursos limitados.
REFERENCIAS (EN ESTE ARTÍCULO)
Bleyer WA. What can be learned about childhood cancer from “Cancer Statistics Review 1973-1988”. Cancer 1993;71:3229-3236.
Kersey JH. Fifty years of studies of the biology and therapy of childhood leukemia. Blood 1997;90:4243-4251.
Berg SL, Grisell DL, DeLaney TF, Balis FM. Principles of treatment of pediatric solid tumors. Pediatr Clin North Am 1991;38:249-267.
Friedman HS, Horowitz M, Oakes WJ. Tumors of the central nervous system. Improvement in outcome through a multimodality approach. Pediatr Clin North Am 1991;38:381-391.
Sandlund JT, Downing JR, Crist WM. Non-Hodgkin lymphoma in childhood. N Engl J Med 1996;334:1238-1248.
Petruzzi MJ, Green DM. Wilms’ tumor. Pediatr Clin North Am 1997;44:939-952.
Gurney JG, Bondy ML. Epidemiology of childhood cancer. In: Pizzo PA, Poplack DG, eds. Principles and Practice of Pediatric Oncology. Philadelphia: Lippincott Williams & Wilkins; 2006. pp. 1-13.
Howard SC, Pedrosa M, Lins M, Pedrosa A, Pui CH, Ribeiro RC, et al. Establishment of a pediatric oncology program and outcomes of childhood acute lymphoblastic leukemia in a resource-poor area. JAMA 2004;291:2471-2475.
Barr R, Ribeiro R, Agarwal B, Masera G, Hesseling P, Magrath I. Pediatric oncology in countries with limited resources. In: Pizzo PA, Poplack DG, eds. Principles and Practice of Pediatric Oncology. Philadelphia: Lippincott Williams & Wilkins; 2006. pp. 1604-1616.
Ribeiro R, Pui CH. Saving the children—improving childhood cancer treatment in developing countries. N Engl J Med 2005;352:2158-2160.
Nolan T, Angos P, Cunha AJ, Muhe L, Qazi S, Simoes EA, et al. Quality of hospital care for seriously ill children in less-developed countries. Lancet 2001;357:106-110.
Masera G, Eden T, Schrappe M, Nachman J, Gadner H, Gaynon P, et al. Statement by members of the Ponte di Legno Group on the right of children to have full access to essential treatment for acute lymphoblastic leukemia. Pediatr Blood Cancer 2004;43:103-104.
The World Bank. The Little Green Data Book 2006. Washington: Communications Development Incorporated; 2006.
Rodgers CC. Resources for children with cancer, their families, and physicians. In: Pizzo PA, Poplack DG, eds. Principles and Practice of Pediatric Oncology. Philadelphia: Lippincott Williams & Wilkins; 2006. pp. 1629-1729.
American Academy of Pediatrics Policy Statement. Organizational principles to guide and define the child health care system and/or improve the health of all children section on hematology/oncology. Guidelines for Pediatric Cancer Centers. Pediatrics 2004;113:1833-1835.
Pasmantier MW, Coleman M, Silver RT, Mamaril AP, Quiguyan CC, Galindo A Jr. Administration of a complex chemotherapy regimen: inpatient versus outpatient treatment. Med Pediatr Oncol 1983;11:333-335.
Jessop DJ, Stein RE. Who benefits from a pediatric home care program? Pediatrics 1991;88:497-505.
Girmenia C, Alimena G, Latagliata R, Morano SG, Celesti F, Coppola L, et al. Out-patient management of acute myeloid leukemia after consolidation chemotherapy. Role of hematologic emergency unit. Haematologica 1999;84:814-819.
Buendia MT, Lozano JM, Suarez G, Saavedra C, Guevara G. The impact of acute lymphoblastic leukemia treatment on central nervous system results in Bogotá-Colombia. J Pediatr Hematol Oncol 2008;30:643-650.
Schrappe M, Reiter A, Ludwig WD, Harbott J, Zimmermann M, Hiddemann W, et al. Improved outcome in childhood acute lymphoblastic leukemia despite reduced use of anthacyclines and cranial radiotherapy: results of trial ALL-BFM 90. German-Austrian-Swiss ALL-BFM Study Group. Blood 2000;95:3310-3322.
Schrappe M, Castillo L, Masera G, Riehm H, Starý J, et al. ALL IC-BFM 2002. A randomized trial of the I-BFM-SG for the management of childhood non-B acute lymphoblastic leukemia. Trial Steering Committee Eds. Final version of Therapy Protocol (May 3, 2002).
Creutzig U, Ritter J, Schellong G. Identification of two risk groups in childhood acute myelogenous leukemia after therapy intensification in study AML-BFM-83 as compared with study AML-BFM-78. AML-BFM Study Group. Blood 1990;75:1932-1940.
Creutzig U, Ritter J, Zimmermann M, Reinhardt D, Hermann J, Berthold F, et al. Improved treatment results in high-risk pediatric acute myeloid leukemia patients after intensification with high-dose cytarabine and mitoxantrone: results of Study Acute Myeloid Leukemia-Berlin-Frankfurt-Munster 93. J Clin Oncol 2001;19:2705-2713.
Magrath IT. Malignant non-Hodgkin’s lymphomas. In: Pizzo PA, Poplack DG, eds. Principles and Practice of Pediatric Oncology. Philadelphia: Lippincott; 1989. pp. 415-455.
Buendia MT, Terselich G, Vega R, Suarez G, Castro E, Posso H. Outcome in extensive abdominal small non-cleaved cell lymphoma (SNCCL) in children. Results with COMP Therapy (abstract). Med Pediatr Oncol 1998;31:266.
Magrath I. Malignant non-Hodgkin’s lymphomas in children. In: Pizzo PA, Poplack DG, eds. Principles and Practice of Pediatric Oncology. Philadelphia: Lippincott; 1993. pp. 537-575.
Ritter J, Schellong G, Wannenmacher M. Treatment of Hodgkin´s disease in children. In: Riehm H, ed. Malignant Neoplasms in Childhood and Adolescence. New York: Karger; 1986. pp. 187-205.
Buendia MT, Terselich G, Rueda E, Zea JM, Vega R, Barbosa G, et al. Retrospective analysis of 168 children with Hodgkin’s disease and long-term follow-up results (abstract). Med Pediatr Oncol 1994;23:228.
Donaldson SS, Hudson MM, Lamborn KR, Link MP, Kun L, Billet AL, et al. VAMP and low-dose, involved-field radiation for children and adolescents with favorable, early-stage Hodgkin’s disease: results of a prospective clinical trial. J Clin Oncol 2002;20:3081-3087.
Sposto R, Ertel IJ, Jenkin RD, Boesel CP, Venes JL, Ortega JA, et al. The effectiveness of chemotherapy for treatment of high grade astrocytoma in children: results of a randomized trial. A report from the Children’s Cancer Study Group. J Neurooncol 1989;7:165-177.
Duffner PK, Cohen ME. Treatment of brain tumors in babies and very young children. Pediatr Neurosci 1985-1986;12:304-310.
Lashford LS, Campbell RH, Gattamaneni HR, Robinson K, Walker D, Bailey C. An intensive multiagent chemotherapy regimen for brain tumours occurring in very young children. Arch Dis Child 1996;74:219-223.
Packer R, Lange B, Ater J, Nicholson HS, Allen J, Walker R, et al. Carboplatin and vincristine for recurrent and newly diagnosed low-grade gliomas of childhood. J Clin Oncol 1993;11:850-856.
Kun LE. Brain tumors. Challenges and directions. Pediatr Clin North Am 1997;44:907-917.
Evans AE, Jenkin RD, Sposto R, Ortega JA, Wilson CB, Wara W, et al. The treatment of medulloblastoma. Results of a prospective randomized trial of radiation therapy with and without CCNU, vincristine and prednisone. J Neurosurg 1990;72:572-582.
Gajjar A. Recent advances in therapy for medulloblastoma. In: American Society of Clinical Oncology, eds. 1999 Spring Educational Book. Alexandria: American Society of Clinical Oncology; 1999. pp. 579-586.
Tait DM, Thornton-Jones H, Bloom HJ, Lemerle J, Morris-Jones P. Adjuvant chemotherapy for medulloblastoma: the first multi-centre control trial of the International Society of Paediatric Oncology (SIOP I). Eur J Cancer 1990;26:464-469.
D’Angio GJ, Breslow N, Beckwith JB, Evans A, Baum H, deLorimier A, et al. Treatment of Wilms’ tumor. Results of the Third National Wilms’ Tumor Study. Cancer 1989;64:349-360.
Green DM, Breslow NE, Beckwith JB, Finklestein JZ, Grundy PE, Thomas PR, et al. Comparison between single-dose and divided-dose administration of dactinomycin and doxorubicin for patients with Wilms’ tumor: a report from the National Wilms’ Tumor Study Group. J Clin Oncol 1998;16:237-245.
Hayes FA, Smith EI. Neuroblastoma. In: Pizzo PA, Poplack DG, eds. Principles and Practice of Pediatric Oncology. Philadelphia: Lippincot; 1989. pp. 607-622.
United Nations General Assembly. 11 October 2002. Twenty-seventh special session, “A world fit for children”, Resolution adopted by the general Assembly [on the report of the Ad Hoc committee of the whole (A/S-27/19/Rev.1 and corr. 1 and 2)] 6th plenary meeting 10 May 2002. A-RES-S27-2E [1].
Berwick DM. Lessons from developing nations on improving health care. BMJ 2004;328:1124-1129.
Blatt J, Copeland DR, Bleyer WA. Late effects of childhood cancer and its treatment. In: Pizzo PA, Poplack DG, eds. Principles and Practice of Pediatric Oncology. Philadelphia: Lippincott; 1993. pp. 1091-1114.
American Academy of Pediatrics. Hepatitis B. In: Pickering LK, ed. Red Book (Libro Rojo). Memoria del Comité de Enfermedades Infecciosas para 2003. México: Intersistemas; 2004. pp. 383-403.
Buitrago B. Patología geográfica: historia natural de las hepatitis B y D en Colombia. Biomédica 1991;11:5-26.
Brown S, Belgaumi A, Ajarim D, Kofide A, Al Saad R, Sabbah R, et al. Loss to follow-up of patients with malignant lymphoma. Eur J Cancer Care (Engl) 2004;13:180-184.
Conter V, Arico M, Valsecchi MG, Rizzari C, Testi AM, Messina C, et al. Extended intrathecal methotrexate may replace cranial irradiation for prevention of CNS relapse in children with intermediate-risk acute lymphoblastic leukemia treated with Berlin-Frankfurt-Münster-based intensive-chemotherapy. The Associazione Italiana di Ematologia ed Oncologia Pediatrica. J Clin Oncol 1995;13:2497-2502.