2007, Número 82
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Rev Enfer Infec Pediatr 2007; 20.21 (82)
Actualidades en alergia a la proteína de leche de vaca
Cervantes BR, Sánchez PMP, Bacarreza ND, Montijo BE, Zárate MF, Mata RN, García CM, Cadena LJF, Ramírez MJA
Idioma: Español
Referencias bibliográficas: 89
Paginas: 51-59
Archivo PDF: 189.02 Kb.
RESUMEN
La prevalencia de alergia a las proteínas de la leche de vaca (APLV), en el ámbito mundial es aproximadamente de 1% a 12%; en México, esta cifra se desconoce. En un alto porcentaje de los casos, no existe la sospecha por parte del personal de salud, y por lo tanto, el diagnóstico y el tratamiento se retrasan. El diagnóstico, en la mayor parte de los casos, es clínico; sin embargo, existen una gran cantidad de pruebas diagnósticas invasivas y no invasivas con sensibilidad y especificidad variables. La prueba de supresión del alérgeno y la respuesta clínica favorable es el método diagnóstico mejor aceptado. El objetivo de esta publicación es dar a conocer una patología (que es más frecuente de lo que se cree) y conocer las manifestaciones clínicas, así como los diferentes métodos diagnósticos y su tratamiento.
REFERENCIAS (EN ESTE ARTÍCULO)
Vanto T, Sinikka. Prediction of the development of tolerate to milk in children with cow’s milk hypersensitivity. J Pediatr 2004;144:218-22.
Kleinman RE. Food sensitivity in pediatric nutrition handbook. AAP 2004;593-606.
Guandalini S. Cow’s milk allergy. En: S Guandalini Essential pediatric gastroenterology, hepatology & nutrition. Mcgraw Hill Editores. Estados Unidos, 2005. p. 175-92.
Heine RG. Pathophysiology, diagnosis and treatment of food protein induced gastrointestinal diseases. Curr Opin Allergy Clin Immunol 2004;4:221-9.
Machteld M, Tiemessen MS. Cow’s milk-specific T cell reactivity of children with and without persistent cow’s milk allergy: Key role for IL-10 J Allergy Clin Immunol 2004;113:932-9.
Sampson HA. Food allergy. Part I: immnopathogenesis and clinical disorders. J Allergy Clin Immunol 1999;103:717-28.
Sampson H: Food allergy. Part II: diagnosis and management. J Allergy Clin Immunol 1999;103:981-9.
MolkhouP. The problems of the child with food allergies. Allerg Immunol 2003;3:7-8.
Sampson HA, Anderson JA. Summary and recommendations: classification of gastrointestinal manifestations due to immunologic reactions to foods in infants and young children, J Pediatr Gastroenterol Nutr 2000;30:S87- S94.
Schrander JJP, van den Bogart JPH, Forget PP, et al. Cow´s milk protein intolerance in infants under 1 year of age: a prospective epidemiological study. Eur J Pediatr 1993;152:640-4.
Host A, Halken S: A prospective study of cow´s milk allergy in Danish infants during the first 3 years of life, Allergy 1990;45:587-96.
Spergel JM, Pawlowski NA. Food allergy. Mechanisms, Diagnosis, and Management in Children. Ped Clin NA 2002;1(49):73-96.
Walker-Smith J. Cow’s milk allergy: a new understanding from immunology. Ann Allergy Asthma Immunol 2003;90(Suppl 3):S81-S83.
Salvatore S, Vandenplas Y. Gastroesophageal reflux and cow milk allergy: is there a link? Pediatrics 2002;110;972-84.
Jarvinen, K. Suomalainen H. Leucocytes in human milk and lymphocyte subsets in cow’s milk allergic infants. Pediatr Allergy Immunol 2002;13(4):243-54.
Tiemessen M. et al. Cow’s milk specific T-cell reactivity of children with and without persistent cow’s milk allergy: Key role for IL-10. J Allergy Clin Immunol 2004;113(5):932-9.
Ruiter B, et al. Characterization of T cell epitopes in alpha s1-casein in cow’s milk allergic atopic, and non atopic children. Clin Exp Allergy 2006;36(3):303-10.
American Academy of Pediatrics. Hypoallergenic infant formulas. Pediatrics 2000;106:346-9.
Magazzú G, Scoglio R. Gastrointestinal manifestations of cow’s milk allergy. Ann Allergy Asthma Immunol 2002;89(Suppl):65-8.
Iacono G, Carroccio A, Montalto G, et al: Severe infantile colic and food intolerance: a long-term prospective study J Pediatr Gastroenterol Nutr 1991;12:332-5.
Iacono G, Carroccio A, Cavataio F, Montalto G, Karsmierska I, Lorello D, et al. Gastroesophageal reflux and cow’s milk allergy in infants: a prospective study. J Allergy Clin Immunol 1996;97:822-7.
Bishop JM, Hill DJ, Hosking CS. Natural history of cow milk allergy: clinical outcome. J Pediatr 1990;116:862-7.
ESPGAN Working group. Diagnostic criteria for food allergy with predominantly intestinal symptoms. J Pediatr Gastroenterol Nutr 1992;14:108-12.
Heine R, Donald JS, Cameron F, Chung Ch, Hill D, Catto- Smith AG. Esophagitis in distressed infants: Poor diagnostic agreement between esophageal pH monitoring and histopathological findings. J Pediatrics 2002;140:14-9.
Gold BD, Co J, Colletti RB, et al. What Outcome Measures Are Needed to Assess Gastroesophageal Reflux Disease in Children? What Study Design Is Appropriate? What New Knowledge Is Needed? J Pediatr Gastroenterol Nutr 2003;37:S72-S75.
Vandenplas Y, Goyvaerts H, Helven R, Sacre L. Gastroesophageal reflux as measured by 24-hour ph monitoring, in 509 healthy infants screened for risk of sudden infant death syndrome. Pediatrics 1991;88:834-40.
Sami B. Clinical expressions of food allergy. Ann allergy Asthma Immunol 2003;90(Suppl 3):41-4.
Sicherer SH. Determinants of systemic manifestations of food allergy. J Allergy Clin Immunol 2000;106:S251-7.
Schandrer JJ, Oudsen S, Forget PP. Follow up study of cow’s milk protein intolerant infants. Eur J Pediatr 1992;151:783-5.
Host A. Cow’s milk protein allergy and intolerance in infancy. Some clinical, epidemiological and immunological aspects. Pediatr Allergy Immunol 1994;5(Suppl 5):1-36.
Sicherer SH. Food allergy: When and how to perform oral food challenges. Pediatr Allergy Immunol 1999;10:226-34.
Host A, Koletzko B, Dreborg S, Muraro A, Wahn U, et al. Dietary products used in infants for treatment and prevention of food allergy. Joint statement of the European Society for Paediatric Allergology and Clinical Immunology (ESPACI) Committee on Hypoallergenic Formulas and the European Society for Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) Committee on Nutrition. Arch Dis Child 1999;81:80-4.
Ritva S, Soili M-K, Kaisu JB, beta-lactoglobulin secretion in human milk varies widely after cow’s milk ingestion in mothers of infants with cow’s milk allergy. J Allergy Clin Immunol 1994;787-92.
Vanto T, et al. The patch test, skin prick test and serum milk-specific IgE as diagnostic tools in cow’s milk allergy in infants. Allergy 1999; 54(8):837-42.
Majamaa H, et al. Cow’s milk allergy: diagnostic accuracy of skin prick and patch tests and specific IgE. Allergy 1999;54(4):436-51.
Saarinen KM, Soumalainen H., Savilahti E. Diagnostic value of skin prick test and patch test and serum eosinophil cationic protein and cow’s milk specific IgE in infants with cow’s milk allergy. Clin Exp Allergy 2001;31(3):423-29.
Keskin O, et al. Evaluation of the utility of the atopy patch testing, skin prick testing and total and specific IgE assays in the diagnosis of cow’s milk allergy. Ann Allergy Asthma Immunol 2005;94(5):553-60.
Verstege A., et al. The predictive value of the skin prick test weal size for the outcome of oral food challenges. Clin Exp Allergy 2005;35(9):1220-6.
Sporik RO., Hill DJ, Hosking CD. Specificity of allergen skin testing in predicting positive open food challenges to milk, egg and peanut in children. Clin Exp Allergy 2000;30(11);1540-6.
Sampson HA. Utility of food specific IgE concentrations in predicting symptomatic food allergy. J Allergy Clin Immunol 2001;107:891-6.
García-Ara C, et al. Specific IgE levels in the diagnosis of immediate hipersensivity cow’s milk protein in the infant. J Allergy Clin Immunol 2001;107:185-90.
García-Ara C, et al. Cow’s milk specific immunoglobulin IgE levels as predictors of clinical reactivity in the follow up of cow’s milk allergy infants. Clin Exp Allergy 2004;34(6):866-70.
Hidvegi E, Cserhati E, Kereki E, Savilahti E, Arato A. Serum immunoglobulin E, IgA and IgG antibodies to different cow’s milk proteins in children with cow’s milk allergy: Association with prognosis and clinical manifestations. Pediatr Allergy Immunol 2002;13(4):255-61.
Ahlstedt S, Holmquist I, Kober A, Perborn H. Accuracy of specific IgE antibody assays for diagnosis of cow’s milk allergy. Ann Allergy Asthma Immunol 2002;89(6)(Suppl 1):21-5.
Turunen S, Tuomo JK, Jorma K. Limphoid nodular hyperplasia and cow’s milk hypersensitivity in children with chronic constipation. J Pediatr 2004;145:606-11.
Kokkonen J, Karttunen TJ. Lymphonodular hyperplasia on the mucosa of the lower gastrointestinal tract in children: an indication of enhanced immune response? J Pediatr Gastroenterol Nutr 2002;34:42-6.
Black DD, Haggitt RC, Orenstein SR, Whitington PF. Esophagitis in infants: morphometric histological diagnosis and correlation with measures of Gastroesophageal reflux. Gastroenterology 1990;98:1408-14.
Hill DJ, Heine RG, Cameron DJ, Catto-Smith AG, Chow CW, Francis DE, et al. Food protein intolerance in infants with persistent distress attributed to reflux esophagitis. J Pediatr 2000;136:641-7.
Kelly KJ, Lazenby AJ, Rowe PC, Yardley JH, Perman JA, Sampson HA. Eosinophilic esophagitis attributed to gastroesophageal reflux: improvement with amino acid-based formula. Gastroenterology 1995;109:1503-12.
Boissieu D, Waguet JC, Dupont C. The atopy patch tests for detection of cow’s milk allergy with digestive symptoms. J Pediatr 2003;142:203-5.
Niggemann S, Reibel UW. The atopy match test (APT) a useful test for the diagnosis of food allergy in children with atopic dermatitis. Allergy 2000;55:281-5.
Mehl A, Rolinck-Werninghaus C, Staden U, Verstege A, Wahn U, Beyer K Niggemann B. The atopy patch test in the diagnostic workup of suspected food-related symptoms in children. J Allergy Clin Immunol 2006;118(4):923-9.
Kalach N, Soulaineu P, de Boissieu D, Dupont C. A pilot study of the usefulness and safety of a ready to use patch test (Dialler test) versus a Comparator (Finn Chamber) during cow’s milk allergy in children. J Allergy Clin Immunol 2005;116(6):1321-6.
Soury D, Barratt G, Ah-Leung S, Legrand P, Chacun H, Ponchel G. Skin localization of cow’s milk proteins delivered by a new ready to use atopy patch test. Pharmaceutical Research 2005;22(9):1530-6.
Hoffman K, Ho D, Sampson H. Evaluation of the usefulness of lymphocyte proliferation assays in the diagnosis of allergy to cow’s milk. J Allergy Clin Immunol 1997;99(3):360-6.
Jarvinen K, Suomalainen H. Leucocytes in human milk and lymphocyte subsets in cow’s milk allergic infants. Pediatr Allergy Immunol 2002;13(4):243-54.
Tiemessen M, et al. Cow’s milk specific T-cell reactivity of children with and without persistent cow’s milk allergy: Key role for IL-10. J Allergy Clin Immunol 2004;113(5):932-9.
Ruiter B, et al. Characterization of T cell epitopes in alpha s1-casein in cow’s milk allergic atopic and non atopic children. Clin Exp Allergy 2006;36(3):303-10.
Bengtsson U, et al. Eosinophil cationic protein and histamine after intestinal challenges in patients with cow’s milk intolerance. J Allergy Clin Immunol 1997;100(2)216-21.
Majamaa H, Aittoniemi J, Miettinen A. Increased concentration of fecal (alpha) 1-antitripsin is associated with cow’s milk allergy in infants with atopic eczema. Clin Exp Allergy 2001;31(4):590-2.
Hidvegi, Cserhati, E, Kereki E, Arato A. Higher serum eosinophil cationic protein levels in children with cow’s milk allergy. J Pediatr Gastroenterol Nutr 2001;32(4):475-9.
Shreffler, W. Evaluation of basophil activation in food allergy: present and future applications. Curr Op Allergy Clin Immunol 2006;6(3):226-33.
Jarvinen K, et al. B-cell epitopes as a screening instrument for persistent cow’s milk allergy. J Allergy Clin Immunol 2002;110(2):293-7.
Lee YH, Food- processing approaches to altering allergenic potential of milk-based formula. J Pediatric 1992;121:S47-50.
European Society of Pediatric Allergy and Clinical Immunology. Hydrolyzed cow’s milk formulae. Allergenicity and use in treatment and prevention. An ESPACI position paper. Pediatr Allergy Immunol 1993;4:101-11.
ESPGAN Committee on Nutrition. Comment on antigen-reduced infant formulae. Acta Paediatr 1993;82:314-19.
Sampson HA, Bernhisel-Broadben J, Yang E, Scanlon SM. Safety of casein hydrolisate formula in children with cow milk allergy. J Pediatr 1991;118: 71-4.
Hill DJ, Cameron DJS, Francis DEM, Gonzalez-Andanza AM, Hosking CS. Challenge confirmation of late-onset reactions to extensively hydrolyzed formulas in infants with multiple food protein intolerance. J Allergy Clin Immunol 1995;96:386-94.
Saylor JD, Bahna SL. Anaphylaxis to casein hydrolisate formula. J Pediatr 1991;118:71-4.
Oldaeus G, Bjorksten B, Einarsson R, Kjellman NIM. Antigenicity and Allergenicity of cow milk hydrolisates intended for infant feeding. Pediatr Allergy Immunol 1991;2:1156-64.
Sampson HA, James JM, Benhisel-Broadben J, Yang E, Scanlon SM. Safety of amino acid derived infant formula in children allergic to cow milk. Pediatrs 1992;90:463-5.
Halken S, Host A, Hansen LG, Osterballe O. Safety of a new ultrafiltered whey hydrolisate formula in children with cow milk allergy: a clinical investigation. Pediatr Allergy Immunol 1993;4:53-9.
Osborn DA, Sinn J. Formulas containing hydrolysed protein for prevention of allergy and food intolerance in infants. Cochrane database System Rev 2003(4):CD003664.
Ramírez Mayans JA, García Campos M. Fórmulas a base de proteínas hidrolizadas en: Manual de Fórmulas Lácteas, sustitutos y complementos nutricionales usados en pediatría. 3a edición. 2007. p. 1-94.
Gilbert RE, Augood C, MacLennan S, et al. Cisapride treatment for gastro-oesophageal reflux in children: a systematic review of randomized controlled trials. J Pediatr Child Health 2000;36:524-9.
Vandenplas Y, Belli D, Benhamou P, et al. A critical reappraisal of current management practices for infant regurgitation: recommendation of a working party. Eur J Pediatr 1997;156:343-57.
Cucchiara S, Minella R, Iervolino C, et al. Omeprazole and high dose ranitidine in the treatment of refractory reflux oesophagitis. Arch Dis Child 1993;69:655-9.
Martin PB, Imong SM, Krischer J, et al. The use of omeprazole for resistant oesophagitis in children. Eur J Pediatr Surg. 1996;6:195-7.
Kato S, Ebina K, Fujii K, et al. Effect of omeprazole in the treatment of refractory acid-related diseases in childhood: endoscope healing and twenty-four intragastric acidity. J Pediatr 1996;128:415-21.
De Giacomo C, Bawa P, Franceschi M, et al. Omeprazole for severe reflux esophagitis in children. J Pediatr Gastroenterol Nutr 1997;24:528-32.
Israel DM, Hassall E. Omeprazole and other proton pump inhibitors: pharmacology, efficacy and safety, with special reference to use in children. J Pediatr Gastroenterol Nutr 1998;27:568-79.
Hassall E, Israel D, Shepherd R, et al. Omeprazole for treatment of chronic erosive esophagitis in children: a multicenter study of efficacy, safety, tolerability and dose requirements. International Pediatric Omeprazole Study Group. J Pediatr 2000;137:800-7.
Kuipers EJ, Meuwissen SGM. The efficacy and safety of long-term omeprazole treatment for gastroesophageal reflux disease. Gastroenterology 2000;118:795-8.
Klinkenber-Knol EC, Nelis F, Dent J, et al. Long-term omeprazole treatment in resistant gastroesophageal reflux disease: efficacy, safety, and influence on gastric mucosa. Gastroenterology 2000;118:661-9.
McGuigan JE. Treatment of gastroesophageal reflux disease: to step or not to step. Am J Gastroenterol 2001;96:1679-81.
Jarvinen KM. Does Low IgA in Human Milk Predispose the Infant to Development of Cow’s Milk Allergy? Pediatr Res 2000;48:457-62.
Zeiger RS, Sampson HA, et al. Soy Allergy in infants and children with IgE-associated cow’s milk allergy. J Pediatr l999;134:614-22.
Bischoffa S Food allergy and the gastrointestinal tract. Current Opinion in Gastroenterology 2004;20:156-61.
Rothenberg ME. Eosinophilic gastrointestinal disorders (EGID). J Allergy Clin Immunol 2004;113:11-28.