2009, Número 4
<< Anterior Siguiente >>
Med Int Mex 2009; 25 (4)
Pancreatitis aguda
Ledesma-Heyer JP, Arias AJ
Idioma: Español
Referencias bibliográficas: 50
Paginas: 285-294
Archivo PDF: 409.68 Kb.
RESUMEN
La pancreatitis aguda es una enfermedad con aumento en su incidencia, que se asocia con mortalidad elevada de los casos graves, y que implica elevación de los costos hospitalarios, incluso tratándose de casos leves. El desarrollo de múltiples sistemas de predicción de su gravedad ha permitido identificar tempranamente sus complicaciones y esto ha reducido la mortalidad asociada. Sin embargo, su tratamiento poco se ha modificado en las últimas décadas, a pesar de la enorme investigación en el área y el desarrollo de medicamentos para disminuir la respuesta inflamatoria asociada. En la actualidad no existe consenso en varios aspectos del tratamiento, como la profilaxis antibiótica. En este artículo se revisan las generalidades de la pancreatitis aguda, se incluyen los sistemas de valoración y predicción de su severidad, y se hace una revisión imparcial del tratamiento médico y quirúrgico.
REFERENCIAS (EN ESTE ARTÍCULO)
Skipworth J, Pereira S. Acute pancreatitis. Curr Opin Crit Care 2008;14:172-8.
Gutiérrez I, Domínguez A, Acevedo J. Mecanismos fisiopatogénicos de la pancreatitis aguda. Cir Gen 2003;25:95-102.
Working Party of the British Society of Gastroenterology. UK guidelines for the management of acute pancreatitis. Gut 2005;54(Suppl. 3):iii1-iii9.
Whitcomb D. Acute pancreatitis. N Engl J Med 2006;354:2142-50.
Sanjay P, Yeeting S, Whigham C, et al. Management guidelines for gallstone pancreatitis. Are the targets achievable? JOP 2009;10:43-47.
Brown A, Young B, Morton J, et al. Are health related outcomes in acute pancreatitis improving? An analysis of national trends in the U.S. from 1997 to 2003. JOP 2008;9:408-14.
Sánchez-Lozada R, Camacho-Hernández MI, Vega-Chavaje RG y col. Pancreatitis aguda: experiencia de cinco años en el Hospital General de México. Gac Med Mex 2005;141:123-7.
Ortega L, Herrera J, Obregón L y col. Morbilidad y mortalidad asociadas a un manejo protocolizado de la pancreatitis aguda. Cir Gen 2003;25:103-11.
Rau B, Kemppainen E, Gumbs A, et al. Early assessment of pancreatic infections and overall prognosis in severe acute pancreatitis by procalcitonin (PCT): A prospective international multicenter study. Ann Surg 2007;245:745-54
Frossard JL, Steer M, Pastor C. Acute pancreatitis. Lancet 2008;371:143-52.
Eddy J, Gideonsen M, Song J, et al. ancreatitis in pregnancy. Obstet Gynecol 2008;112:1075-81.
Chavez M. Historia del pancreas y de la evolución de los conceptos y la clasificación de la pancreatitis. Rev Gastroenterol Peru 2002;22:243-7.
Pandol S. Acute pancreatitis. Curr Opin Gastroenterol 2005;21:538-43.
Hanck C, Whitcomb D. Alcoholic pancreatitis. Gastroenterol Clin North Am 2004;33:751-65.
Swaroop VS, Chari ST, Clain JE. Severe acute pancreatitis. JAMA 2004;291(23):2865-8.
Dahl PR, Su WP, Cullimore KC, Dicken CH. Pancreatic panniculitis. J Am Acad Dermatol 1995;33:413-7.
Bennett RG, Petrozzi JW. Nodular subcutaneous fat necrosis. A manifestation of silent pancreatitis. Arch Dermatol 1975;111(7):896-8.
Kingsnorth A, O’Reilly D. Acute pancreatitis. BMJ 2006;332:1072-6.
Toouli J, Brooke-Smith, M, Bassi, C, et al. Working party report: guidelines for the management of acute pancreatitis. J Gastroenterol Hepatol 2002;17:S1.
Yousaf M, McCallion K, Diamond T. Management of severe acute pancreatitis. Br J Surg 2003;90:407-20.
Tenner S, Dubner H, Steinberg W. Predicting gallstone pancreatitis with laboratory parameters: a meta-analysis. Am J Gastroenterol 1994;89:1863-6.
Agarwal N, Pitchumoni CS, Sivaprasad AV. Evaluating tests for acute pancreatitis. Am J Gastroenterol 1990;85:356-66.
Kylanpaa-Back M, Kemppainen E, Puolakkainen P, et al. Reliable screening for acute pancreatitis with rapid urine trypsinogen-2 test strip. Br J Surg 2000;87(1):49-52.
Heinrich S, Schafer M, Rousson V, Clavien PA. Evidencebased treatment of acute pancreatitis: a look at established paradigms. Ann Surg 2006;243:154-68.
Balthazar EJ. Acute pancreatitis: assessment of severity with clinical and CT evaluation. Radiology 2002;223:603-13.
Arvanitakis M, Delhaye M, De Maertelaere V, et al. Computed tomography and magnetic resonance imaging in the assessment of acute pancreatitis. Gastroenterology 2004;126:715-23.
Ranson JH, Rifkind KM, Roses DF, Fink SD, et al. Prognostic signs and the role of operative management in acute pancreatitis. Surg Gynecol Obstet 1974;139:69-81.
Buter A, Imrie CW, Carter CR, et al. Dynamic nature of early organ dysfunction determines outcome in acute pancreatitis. Br J Surg 2002;89:298-302.
Uscanga-Domínguez LF, Herrera-Ascencio E, Enriquez JR y col. La identificacióndel enfermo con pancreatitis aguda grave. Un estudio prospectivo, comparativo entre los criterios de Ranson y los del Instituto Nacional de la Nutrición “Salvador Zubirán”. Gac Med Mex 1998;134:283.
Bradley EL III. A clinically based classification system for acute pancreatitis. Summary of the International Symposium on Acute Pancreatitis. Atlanta, Ga. September 11 through 13, 1992. Arch Surg 1993;128:586-90.
Knaus WA, Draper EA, Wagner DP, et al. APACHE II: a severity of disease classification system. Crit Care Med 1985;13:818-29.
Harrison D, D’Amico G, Singer M. The Pancreatitis Outcome Prediction (POP) score: a new prognostic index for patients with severe acute pancreatitis. Crit Care Med 2007;35:1703-8.
Martinez J, Johnson CD, Sanchez-Paya J, et al. Obesity is a definitive risk factor of severity and mortality in acute pancreatitis: an updated meta-analysis. Pancreatology 2006;6:206-9.
De Campos T, Cerqueira C, Kuryura L, et al. Morbimortality indicators in severe acute pancreatitis. JOP 2008;9:690-7.
Vincent JL, Moreno R, Takala J, et al. The SOFA (Sepsisrelated Organ Failure Assessment) score to describe organ dysfunction/failure. On behalf of the Working Group on Sepsis-Related Problems of the European Society of Intensive Care Medicine. Intensive Care Med 1996;22:707-10.
Marshall JC, Cook DJ, Christou NV, et al. Multiple organ dysfunction score: a reliable descriptor of a complex clinical outcome. Crit Care Med 1995;23:1638-52.
Ioannidis O, Lavrentieva A, Botsios D. Nutrition support in acute pancreatitis. JOP 2008;9:375-90.
Eatock FC, Chong P, Menezes N, et al. A randomized study of early nasogastric versus nasojejunal feeding in severe acute pancreatitis. Am J Gastroenterol 2005;100(2):432-9.
McClave S. Nutrition support in acute pancreatitis. Gastroenterol Clin North Am 2007;36:65-74.
Beglinger M, Gullo L, Laugier R, et al. ESPEN guidelines on nutrition in acute pancreatitis. Clin Nutr 2002;21:173-83.
Besselink MG, van Santvoort HC, Buskens E, Boermeester MA, et al. Probiotic prophylaxis in predicted severe acute pancreatitis: a randomized, double-bind, placebo-controled controlled trial. Lancet 2008;371:651-9.
Mazaki T, Ishii Y, Takayama T. Meta-analysis of prophylactic antibiotic use in acute necrotizing pancreatitis. Br J Surg 2006;93(6):674-84.
Isenmann R, Runzi M, Kron M, et al. Prophylactic antibiotic treatment in patients with predicted severe acute pancreatitis: a placebo-controlled, double-blind trial. Gastroenterology 2004;126:997-1004.
Uhl W, Warshaw A, Imrie C, et al. IAP guidelines for the surgical management of acute pancreatitis. Pancreatology 2002;2:565-73.
Hines O, Reber H. Pancreatic surgery. Curr Opin Gastroenterol 2005;21:568-72.
Petrov M, Santvoort H, Besselink M, et al. Early endoscopic retrograde cholangiopancreatography versus conservative management in acute biliary pancreatitis without cholangitis: a meta-analysis of randomized trials. Ann Surg 2008;247:250-7.
Van Santvoort HC, Besselink MG, de Vries AC, et al. Early ERCP is only beneficial in predicted severe acute biliary pancreatitis in presence of cholestasis: a prospective multicenter study. Pancreatology 2008;8:337-8.
Acosta JM, Ronzano GD, Pellegrini CA. Ampullary obstruction monitoring in acute gallstone pancreatitis: a safe, accurate, and reliable method to detect pancreatic ductal obstruction. Am J Gastroenterol 2000;95:122-7.
Nealon W, Bawduniak J, Walser E. Appropriate timing of cholecystectomy in patients who present with moderate to severe gallstone-associated acute pancreatitis with peripancreatic fluid collections. Ann Surg 2004;239:741-751.
Zhang X, Dijiong W, Jiang X. ICAM-1 and acute pancreatitis complicated by acute lung injury. JOP 2009;10:8-14.