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Colegio de Medicina Interna de México.

2009, Número 3

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Med Int Mex 2009; 25 (3)


Mitos y realidad de la hemoglobina glucosilada

Pérez PI, Rodríguez WFL, Díaz Greene EJ, Cabrera JR

Idioma: Español
Referencias bibliográficas: 50
Paginas: 202-209
Archivo PDF: 282.10 Kb.


RESUMEN

La diabetes mellitus es un padecimiento que ha tenido grandes repercusiones en la salud pública; en la actualidad es la principal causa de morbilidad y mortalidad en la República Mexicana. A lo largo de los años, diferentes estudios han mostrado la asociación entre el descontrol glucémico y las complicaciones crónicas (microvasculares o macrovasculares, o ambas). La determinación de la glucosilación no enzimática de las proteínas sanguíneas establecida mediante las concentraciones de hemoglobina glucosilada ha demostrado ser un parámetro objetivo del control glucémico a través de un tiempo determinado. Existe un consenso internacional acerca de la medición y la interpretación de la hemoglobina glucosilada y sus resultados pueden variar en función de ciertas condiciones clínicas de los pacientes. No hay un valor único de hemoglobina glucosilada que sea aplicable a toda la población de diabéticos, por lo que la meta será llevar a los pacientes a concentraciones de glucosa lo más cercanas a la normalidad. Esto se reflejará en concentraciones de hemoglobina glucosilada y, lo más importante, en complicaciones crónicas asociadas a diabetes mellitus.


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