Carrillo-Esper R, Sosa-García JO

Idioma: Español
Referencias bibliográficas: 22
Paginas: 172-174
Archivo PDF: 96.81 Kb.

FRAGMENTO

Introducción

Endo, en 1976 aisló las estatinas a partir del moho Penicillium citrinium. La primera estatina estudiada en seres humanos fue la mevastatina. Albert, creó la primera estatina (Lovastatina), aislada de Aspergillus terreus y aprobada para uso en seres humanos.
Las estatinas son altamente efectivas reduciendo los niveles plasmáticos de colesterol al inhibir de manera competitiva la 3-hidroxi-3-metil-glutaril coenzima A reductasa (HMG-CoA reductasa), disminuyendo los niveles plasmáticos de colesterol total (60-65%), lipoproteínas de baja densidad (LDL) del 25-40%, triglicéridos e incrementando las lipoproteínas de alta densidad (HDL) en un 5-20%.

REFERENCIAS (EN ESTE ARTÍCULO)

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