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2009, Número 3

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Rev Inst Nal Enf Resp Mex 2009; 22 (3)


La infección con Mycobacterium tuberculosis incrementa la producción de óxido nítrico y TNF-α en macrófagos alveolares de contactos intradomiciliarios de pacientes con tuberculosis

Carranza C, Juárez E, Sarabia C, Escobedo D, Sada E, Torres M

Idioma: Español
Referencias bibliográficas: 22
Paginas: 163-170
Archivo PDF: 102.21 Kb.


RESUMEN

Los contactos intradomiciliarios de pacientes con tuberculosis parecen ser una población protegida que desarrolla una memoria específica contra Mycobacterium tuberculosis. En este trabajo se evaluó la capacidad de los macrófagos alveolares de contactos intradomiciliarios y de sujetos controles de la comunidad para producir óxido nítrico (NO) y factor de necrosis tumoral alfa (TNF-α) en respuesta a la infección con M. tuberculosis cepas H37Ra (avirulenta) y H37Rv (virulenta). Nuestros resultados muestran que la producción de NO y TNF-a en los sobrenadantes de cultivos de macrófagos alveolares provenientes de controles intradomiciliarios se incrementó en los días 4 y 7. En contraste, la producción de NO y TNF-α fue menor en los macrófagos de los controles comunitarios. Estos resultados sugieren que la producción local de NO y TNF-α desempeña un papel importante en el control de la tuberculosis en individuos expuestos a la infección.


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